PDF
Abstract
A number of diagnostic techniques exist to ascertain whether a mouth lesion could become an oral cancer. In a review article, Diana V Messadi from the University of California, Los Angeles School of Dentistry, USA, details the known pathological conditions considered to be precancerous. These include leukoplakia and erythroplakia, both of which are marked by abnormally colored patches of cells on the mucous membrane that lines that inside of our cheeks, as well as the inflammatory diseases oral lichen planus and oral submucous fibrosis. Messadi also catalogues non-invasive screening tools such as dye systems, fluorescent technologies and cell-collection kits, all of which can catch signs of cancer before lesions turn malignant. She notes that early diagnosis is the most important predictor of patient outcome for anyone with oral cancer, requiring dentists to have adequate knowledge and training.
Keywords
early diagnosis
/
non-invasive detection tools
/
oral precancerous lesions
Cite this article
Download citation ▾
Diana V Messadi.
Diagnostic aids for detection of oral precancerous conditions.
International Journal of Oral Science, 2013, 5(2): 59-65 DOI:10.1038/ijos.2013.24
| [1] |
Johnson NW, Warnakulasuriya S, Gupta PC. Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions. Adv Dent Res, 2011, 23(2): 237-246.
|
| [2] |
Siegel R, Naishadham D, Jemal A. Cancer statistics. CA Cancer J Clin, 2012, 62(1): 10-29.
|
| [3] |
Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med, 2008, 7(1): 1-10.
|
| [4] |
van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol, 2009, 45(4/5): 317-323.
|
| [5] |
Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for squamous cell carcinoma of the oral cavity in young people—a comprehensive literature review. Oral Oncol, 2001, 37(5): 401-418.
|
| [6] |
Lingen MW, Pinto A, Mendes RA. Genetics/epigenetics of oral premalignancy: current status and future research. Oral Diseases, 2011, 17(Suppl 1): 7-22.
|
| [7] |
Albo D, Granick MS, Jhala N. The relationship of angiogenesis to biological activity in human squamous cell carcinomas of the head and neck. Ann Plast Surg, 1994, 32(6): 588-594.
|
| [8] |
Guillaud M, Zhang L, Poh C. Potential use of quantitative tissue phenotype to predict malignant risk for oral premalignant lesions. Cancer Res, 2008, 68(9): 3099-3107.
|
| [9] |
Ho PS, Chen PL, Warnakulasuriya S. Malignant transformation of oral potentially malignant disorders in males: a retrospective cohort study. BMC Cancer, 2009, 9: 260-267.
|
| [10] |
Barnes L, Eveson JW, Reichart P. World health organization. Classification of tumours. Pathology and genetics of head and neck tumours, 2005 Lyon 283-328.
|
| [11] |
Arduino PG, Surace A, Carbone M. Outcome of oral dysplasia: a retrospective hospital-based study of 207 patients with a long follow-up. J Oral Pathol Med, 2009, 38(6): 540-544.
|
| [12] |
Mehanna HM, Rattay T, Smith J. Treatment and follow-up of oral dysplasia—a systematic review and meta-analysis. Head Neck, 2009, 31(12): 1600-1609.
|
| [13] |
Leemans CR, Boudewijn JM, Braakhuis JM. The molecular biology of head and neck cancer. Nat Rev Cancer, 2011, 11(1): 9-22.
|
| [14] |
Bremmer JF, Braakhuis BJ, Brink J. A noninvasive genetic screening test to detect oral preneoplastic lesions. Lab Invest, 2005, 85(12): 1481-1488.
|
| [15] |
Bremmer JF, Graveland AP, Braakhuis BJ. Screening for oral precancer with noninvasive genetic cytology. Cancer Prev Res, 2009, 2(1): 128-133.
|
| [16] |
Shpitzer T, Hamzany Y, Bahar G. Salivary analysis of oral cancer biomarkers. Br J Cancer, 2009, 101(7): 1194-1198.
|
| [17] |
Liu J, Duan Y. Saliva: a potential media for disease diagnostics and monitoring. Oral Oncol, 2012, 48(7): 569-577.
|
| [18] |
Mehrotra R, Gupta DK. Exciting new advances in oral cancer diagnosis: avenues to early detection. Head Neck Oncol, 2011, 3: 33-40.
|
| [19] |
Lange CJ. Exploring biomarkers in head and neck cancer. Cancer, 2012, 118(16): 3882-3892.
|
| [20] |
Carnelio S, Rodrigues SJ, Shenoy R. A brief review of common oral premalignant lesions with emphasis on their management and cancer prevention. Indian J Surg, 2011, 73(4): 256-261.
|
| [21] |
Silverman S Jr, Gorsky M, Lozada F. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer, 1984, 53(3): 563-568.
|
| [22] |
Silverman S Jr. Demographics and occurrence of oral and pharyngeal cancers: the outcomes, the trends, the challenge. J Am Dent Assoc, 2001, 132(Suppl 1): 7S-11S.
|
| [23] |
Cabay JR, Morton AH Jr, Epstein JB. Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. J Oral Pathol Med, 2007, 36(5): 255-261.
|
| [24] |
Villa A, Villa C, Abati S. Oral cancer and oral erythroplakia: an update and implication for clinicians. Aust Dent J, 2011, 56(3): 253-256.
|
| [25] |
Feller L, Lemmer J. Oral leukoplakia as it relates to HPV infection: a review. Int J Dent, 2012, 2012: 540561.
|
| [26] |
Grinde B, Olsen I. The role of viruses in oral disease. J Oral Microbiol, 2010, 2: 2127-2135.
|
| [27] |
D’Souza G, Dempsey A. The role of HPV in head and neck cancer and review of the HPV vaccine. Prev Med, 2011, 53(Suppl 1): S5-S11.
|
| [28] |
Ostwald C, Rutsatz K, Schweder JW. Human papillomavirus 6/11, 16 and 18 in oral carcinomas and benign oral lesions. Med Microbiol Immunol, 2003, 192(3): 145-148.
|
| [29] |
Hennessey PT, Westra HW, Califano JA. Human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications. J Dent Res, 2009, 88(4): 300-306.
|
| [30] |
Wise-Draper TM, Wells SI. Papillomavirus E6 and E7 proteins and their cellular targets. Front Biosci, 2008, 13: 1003-1017.
|
| [31] |
Nasman A, Attner P, Hammarstedt L. Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma. Int J Cancer, 2009, 125(2): 362-366.
|
| [32] |
Schlecht HP. Oral human papillomavirus infection hazard of intimacy. J Am Med Assoc, 2012, 307(7): 724-725.
|
| [33] |
Ho PS, Yang YH, Shieh TY. Consumption of areca quid, cigarettes, and alcohol related to the comorbidity of oral submucous fibrosis and oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007, 104(5): 647-652.
|
| [34] |
Shahid RA. Coming to America: betel nut and oral submucous fibrosis. J Am Dent Assoc, 2010, 141(4): 423-428.
|
| [35] |
Bhattacharyya I, Chehal HK. White lesions. Otolaryngol Clin N Am, 2011, 44(1): 109-131.
|
| [36] |
Sugerman PB, Savage NW, Walsh LJ. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med, 2002, 13(4): 350-365.
|
| [37] |
Sugerman PB, Savage NW, Zhou X. Oral lichen planus. Clin Dermatol, 2000, 18(5): 533-539.
|
| [38] |
Le Cleach L, Chosidow O. Clinical practice. Lichen planus. N Engl J Med, 2012, 366(8): 723-732.
|
| [39] |
van der Waal I. Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects. Med Oral Patol Oral Cirt Bucal, 2009, 14(7): E310-E314.
|
| [40] |
Ho MW, Risk JM, Woolger JA. The clinical determinants of malignant transformation in oral epithelial dysplasia. Oral Oncol, 2012, 48(10): 969-976.
|
| [41] |
Messadi DV, Wilder-Smith P, Wolinsky L. Improving oral cancer survival: the role of dental providers. J Calif Dent Assoc, 2009, 37(11): 789-798.
|
| [42] |
Steele TO, Meyers A. Early detection of premalignant lesions and oral cancer. Otolaryngol Clin N Am, 2011, 44(7): 221-229.
|
| [43] |
Nair D, Pruthy R, Pawar U. Oral cancer: premalignant conditions and screening—an update. J Can Res Therap, 2012, 8(Suppl 1): s57-s66.
|
| [44] |
Fedele S. Diagnostic aids in the screening of oral cancer. Head Neck Oncol, 2009, 1: 5-10.
|
| [45] |
Epstein JB, Silverman S Jr, Epstein JD. Analysis of oral lesion biopsies identified and evaluated by visual examination, chemiluminescence and toluidine blue. Oral Oncol, 2008, 44(6): 538-544.
|
| [46] |
Lingen MW, Kalmar JR, Karrison T. Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol, 2008, 44(1): 10-22.
|
| [47] |
Rosin MP, Poh CF, Guillard M. Visualization and other emerging technologies as change makers for oral cancer prevention. Ann NY Acad Sci, 2007, 1098: 167-183.
|
| [48] |
Patton LL, Epstein JB, Kerr AR. Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature. J Am Dent Assoc, 2008, 139(7): 896-905.
|
| [49] |
Su WW, Yen AM, Chiu SY. A community-based RCT for oral cancer screening with toluidine blue. J Dent Res, 2010, 89(9): 933-937.
|
| [50] |
Awan KH, Yang YH, Morgan PR. Utility of toluidine blue as a diagnostic adjunct in the detection of potentially malignant disorders of the oral cavity—a clinical and histological assessment. Oral Dis, 2012, 18(8): 728-733.
|
| [51] |
Sciubba JJ. Improving detection of precancerous and cancerous oral lesions. Computer-assisted analysis of the oral brush biopsy. U.S. Collaborative OralCDx Study Group. J Am Dent Assoc, 1999, 130(10): 1445-1457.
|
| [52] |
Rick GM. Oral brush biopsy: the problem of false positives. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2003, 96(3): 252-258.
|
| [53] |
Svirsky JA, Burns JC, Carpenter WM. Comparison of computer-assisted brush biopsy results with follow up scalpel biopsy and histology. Gen Dent, 2002, 50(6): 500-503.
|
| [54] |
Scheifele C, Schimdt-Westhausen A, Detrich T. The sensitivity and specificity of the OralCDx technique: evaluation of 103 cases. Oral Oncol, 2004, 40(8): 824-828.
|
| [55] |
Huber MA, Bsoul SA, Terezhalmy GT. Acetic acid wash and chemiluminescent illumination as an adjunct to conventional oral soft tissue examination for the detection of dysplasia: a pilot study. Quintessence Int, 2004, 35(5): 378-384.
|
| [56] |
Kerr AR, Sirois DA, Epstein JB. Clinical evaluation of chemiluminescent lighting: an adjunct for oral mucosal examinations. J Clin Dent, 2006, 17(3): 59-63.
|
| [57] |
Epstein JB, Gorsky M, Lonky S. The efficacy of oral lumenoscopy™ (ViziLite®) in visualizing oral mucosal lesions. Spec Care Dent, 2006, 26(4): 171-174.
|
| [58] |
McIntosh L, McCullough MJ, Farah CS. The assessment of diffused light illumination and acetic acid rinse (Microlux/DL) in the visualisation of oral mucosal lesions. Oral Oncol, 2009, 45(12): 227-231.
|
| [59] |
Lam S, MacAulay C, Palcic B. Detection and localization of early lung cancer by imaging techniques. Chest, 1993, 103(1 Suppl): 12S-14S.
|
| [60] |
Park SY, Follen M, Milbourne A. Automated image analysis of digital colposcopy for the detection of cervical neoplasia. J Biomed Opt, 2008, 13(1): 014029.
|
| [61] |
Kennedy JC, Pottier RH. Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J Photochem Photobiol B, 1992, 14(4): 275-292.
|
| [62] |
Ebihara A, Liaw LH, Krasieva TB. Detection and diagnosis of oral cancer by light-induced fluorescence. Lasers Surg Med, 2003, 32(1): 17-24.
|
| [63] |
Schantz SP, Kolli V, Savage HE. In vivo native cellular fluorescence and histological characteristics of head and neck cancer. Clin Cancer Res, 1998, 4(5): 1177-1182.
|
| [64] |
Sweeny L, Dean NR, Magnuson JS. Assessment of tissue autofluorescence and reflectance for oral cavity cancer screening. Otolaryngol Head Neck Surg, 2012, 145(6): 956-960.
|
| [65] |
Lane PM, Gilhuly T, Whitehead P. Simple device for the direct visualization of oral-cavity tissue fluorescence. J Biomed Opt, 2006, 11(2): 024006.
|
| [66] |
Poh CF, Ng SP, Williams PM. Direct fluorescence visualization of clinically occult high-risk oral premalignant disease using a simple hand-held device. Head Neck, 2007, 29(1): 71-76.
|
| [67] |
Balevi B. Evidence-based decision making: should the general dentist adopt the use of the VELscope for routine screening for oral cancer. J Can Dent Assoc, 2007, 73(7): 603-606.
|
| [68] |
Camiles F, Mcintosh L, Georgiou A. Efficacy of tissue autofluorescence imaging (Velscope) in the visualization of oral mucosal lesions. Head Neck, 2012, 34(6): 856-862.
|
| [69] |
Awan KH, Morgan PR, Warnakulasuriya S. Evaluation of an autofluorescence based imaging system (VELscopeTM) in the detection of oral potentially malignant disorders and benign keratosis. Oral Oncol, 2011, 47(4): 274-277.
|
| [70] |
Roblyer D, Kurachi C, Stepanek V. Objective detection and delineation of oral neoplasia using autofluorescence imaging. Cancer Prev Res, 2009, 2(5): 423-431.
|
| [71] |
Folkman J, Watson K, Ingber D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature, 1989, 339(6219): 58-61.
|
| [72] |
Hasina R, Lingen MW. Angiogenesis in oral cancer. J Dent Educ, 2001, 65(11): 1282-1290.
|
| [73] |
Schwarz RA, Gao W, Redden Weber C. Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy: simple device for the direct visualization of oral-cavity tissue fluorescence. Cancer, 2009, 115(8): 1669-1679.
|
| [74] |
McGee SA, Mirkovic J, Mardirossian V. Model-based spectroscopic analysis of the oral cavity: impact of anatomy. J Biomed Opt, 2008, 13(6): 064034.
|
| [75] |
Koch FP, Kaemmerer PW, Biesterfeld S. Effectiveness of autofluorescence to identify suspicious oral lesions-a prospective, blinded clinical trial. Clin Oral Investig, 2011, 15(6): 975-982.
|
| [76] |
Forde MD, Koka S, Eckert SE. Systemic assessments utilizing saliva: part 1 general considerations and current assessments. Int J Prosthodont, 2006, 19(1): 43-52.
|
| [77] |
Pesce MA, Spitalnik SL. Saliva and the clinical pathology laboratory. Ann NY Acad Sci, 2007, 1098: 192-199.
|
| [78] |
Li Y, St John MA, Zhou X. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res, 2004, 10(24): 8442-8450.
|
| [79] |
Wong DT. Towards a simple, saliva-based test for the detection of oral cancer, oral fluid (saliva), which is the mirror of the body, is a perfect medium to be explored for health and disease surveillance. Expert Rev Mol Diagn, 2006, 6(3): 267-272.
|
| [80] |
Wong DT. Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J Am Dent Assoc, 2006, 137(3): 313-321.
|