Chondrogenesis of periodontal ligament stem cells by transforming growth factor-β3 and bone morphogenetic protein-6 in a normal healthy impacted third molar

Abstract

Human stem cells taken from the connective tissue that attaches teeth to the underlying bone can give rise to new cartilage. Because such tissue can be obtained fairly easily during dental surgery, the findings—reported by Jaejin Cho and his co-workers at the Seoul National University, Korea—suggest that patient-specific dental stem cells could provide a personalized way to treat a number of cartilage and bone disorders. Cho’s team isolated dental stem cells from the connective tissue, or periodontal fibers, attached to an impacted third molar taken from an otherwise healthy donor. They added growth factors to induce a process called ‘chondrogenesis’ and ran a battery of genetic, chemical and histological tests to demonstrate that the cells had taken the first steps toward cartilage formation.

Keywords

bone morphogenetic protein-6 / chondrogenesis growth factor / periodental ligament cell / stem cell / transforming growth factor-β3

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