The similarity between human embryonic stem cell-derived epithelial cells and ameloblast-lineage cells

Abstract

Cells derived from human embryonic stem cells express a similar suite of genes as the precursor cells that eventually deposit tooth enamel. The findings highlight the potential of one day using such stem cells to help regenerate the hard tissue that coats the outside surface of teeth. A team led by Yan Zhang of the University of California, San Francisco, compared the gene expression profiles of embryonic stem cells, coaxed partially down a pathway toward an enamel-producing fate, with true enamel-forming precursor cells taken from human fetal teeth. They showed that both cell types expressed CK76, a gene encoding a fibrous structural protein known as keratin that makes up the bulk of the enamel matrix, in addition to various other genes that affect the deposition of this protective tooth layer.

Keywords

ameloblast / cytokeratin / dental epithelial cells / human embryonic stem cells / odontogenesis

References

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