Low-grade myofibroblastic sarcoma of the palate

Abstract

Low-grade myofibroblastic sarcoma (LGMS) is a rare, malignant tumor with myofibroblastic differentiation. Despite it being classified as a distinct entity by the World Health Organization, a few cases were reported in the oral and maxillofacial region. Here, a LGMS developed on the palate of a 73-year-old man who presented with a 1-cm tumor on the posterior border of the palate. Based on the histological and immunohistochemical features, a diagnosis of LGMS was established. The tumor was resected, and no recurrence was observed over 2 years. Although the tongue is the most preferred site for LGMS, it may occur in any region of the oral cavity.

Keywords

low-grade myofibroblastic sarcoma / oral / palate

References

[1] Tomasek JJ, Gabbiani G, Hinz B. Myofibroblasts and mechano-regulation of connective tissue remodeling. Nat Rev Mol Cell Biol, 2002, 3(5): 349-363.

[2] Mentzel T, Fletcher JA. Low grade myofibroblastic sarcoma. Pathology and genetics of tumours of soft tissue and bone., 2002 Lyon 94-95.

[3] Montgomery E, Goldblum JR, Fisher C. Myofibrosarcoma: a clinicopathologic study. Am J Surg Pathol, 2001, 25(2): 219-228.

[4] Takacsi-Nagy Z, Murakozy G, Pogany P. Myofibroblastic sarcoma of the base of tongue. Case report and review of the literature. Strahlenther Onkol, 2009, 185(3): 198-201.

[5] Bisceglia M, Tricarico N, Minenna P. Myofibrosarcoma of the upper jawbones: a clinicopathologic and ultrastructural study of two cases. Ultrastruct Pathol, 2001, 25(5): 385-397.

[6] Meng GZ, Zhang HY, Bu H. Myofibroblastic sarcoma of the nasal cavity and paranasal sinus: a clinicopathologic study of 6 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007, 104(4): 530-539.

[7] Meng GZ, Zhang HY, Bu H. Myofibroblastic sarcomas: a clinicopathological study of 20 cases. Chin Med J, 2007, 120(5): 363-369.

[8] Fisher C. Myofibroblastic malignancies. Adv Anat Pathol, 2004, 11(4): 190-201.

[9] Mentzel T, Dry S, Katenkamp D. Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors. Am J Surg Pathol, 1998, 22(10): 1228-1238.

[10] Demarosi F, Bay A, Moneghini L. Low-grade myofibroblastic sarcoma of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009, 108(2): 248-254.

[11] Meng GZ, Zhang HY, Zhang Z. Myofibroblastic sarcoma vs nodular fasciitis: a comparative study of chromosomal imbalances. Am J Clin Pathol, 2009, 131(5): 701-709.

[12] Jay A, Piper K, Farthing PM. Low-grade myofibroblastic sarcoma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007, 104(5): e52-e58.

[13] Fujiwara M, Yuba Y, Wada A. Myofibrosarcoma of the nasal bone. Am J Otolaryngol, 2005, 26(4): 265-267.

[14] Keller C. Low-grade myofibrosarcoma of the head and neck: importance of surgical therapy. J Pediatr Hematol Oncol, 2004, 26(2): 119-120.

[15] Niedzielska I, Janic T, Mrowiec B. Low-grade myofibroblastic sarcoma of the mandible: a case report. J Med Case Reports, 2009, 10(3): 8458.

[16] Eyden BP, Banerjee SS, Harris M. A study of spindle cell sarcomas showing myofibroblastic differentiation. Ultrastruct Pathol, 1991, 15(4/5): 367-378.

[17] Eyden BP, Christensen L, Tagore V. Myofibrosarcoma of subcutaneous soft tissue of the cheek. J Submicrosc Cytol Pathol, 1992, 24(3): 307-313.

[18] Smith DM, Mahmoud HH, Jenkins JJ 3rd. Myofibrosarcoma of the head and neck in children. Pediatr Pathol Lab Med, 1995, 15(3): 403-418.

[19] Bisceglia M, Magro G. Low-grade myofibroblastic sarcoma of the salivary gland. Am J Surg Pathol, 1999, 23(11): 1435-1436.

[20] Kondo S, Yoshizaki T, Minato H. Myofibrosarcoma of the nasal cavity and paranasal sinus. Histopathology, 2001, 39(2): 216-217.

[21] Artopoulou II, Lemon JC, Clayman GL. Stent fabrication for graft immobilization following wide surgical excision of myofibroblastic sarcoma of the buccal mucosa: a clinical report. J Prosthet Dent, 2006, 95(4): 280-285.

[22] Laco J, Simakova E, Slezak R. Low grade myofibroblastic sarcoma of tongue: a case report. Cesk Patol, 2006, 42(3): 150-153.

[23] Takahama A Jr, Nascimento AG, Brum MC. Low-grade myofibroblastic sarcoma of the parapharyngeal space. Int J Oral Maxillofac Surg, 2006, 35(10): 965-968.

[24] Imanguli MM, Karai LJ, Shanti RM. Myofibroblastic tumor of the lower lip in a patient with X-linked hypogammaglobulinemia and isolated growth hormone deficiency: a case report. J Oral Maxillofac Surg, 2007, 65(6): 1219-1222.