Cementomimetics—constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides

Abstract

New understanding of protein–mineral interactions has led to a method of repairing diseased teeth using peptide coatings, a US study reveals. Mehmet Sarikaya of the University of Washington and co-workers at institutions around the USA have deconstructed the dental enamel protein amelogenin to identify natural peptides that share useful characteristics with crystal-binding peptides (hydrozyapatites). They found that one such peptide — ADP5 — binds with demineralized tooth dentin to form a strong layer. This behavior is very similar to natural cementum, which covers tooth roots and helps hold teeth in place. Cementum is, however, very prone to disease through infections that decrease its ability to mineralize. ADP5 appears to mimic cementum mineralization, and could be used to form a protective layer over diseased teeth, allowing regeneration to begin.

Keywords

amelogenin / amelogenin-derived peptides / bioinformatics / biomineralization / cementomimetics / cementum / demineralization / remineralization

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