Effect of Sr²⁺ on 3D gel-printed Sr_3−xMg _x(PO₄)₂ composite scaffolds for bone tissue engineering

Abstract

Porous magnesium strontium phosphate (Sr_3−xMg _x(PO₄)₂) (x = 2, 2.5, 3) composite scaffolds were successfully prepared by three dimension gel-printing (3DGP) method in this study. The results show that Sr_0.5Mg_2.5(PO₄)₂ scaffolds had good compressive strength, and Sr_1.0Mg_2.0(PO₄)₂ scaffolds had good degradation rate in vitro. The weight loss rate of Sr_1.0Mg_2.0(PO₄)₂ scaffolds soaked in simulated body fluid (SBF) or 6 weeks was 6.96%, and pH value varied between 7.50 and 8.61, which was within the acceptable range of human body. Preliminary biological experiment shows that MC3T3-E1 cells had good adhesion and proliferation on the surface of Sr_3−xMg _x(PO₄)₂ scaffolds. Compared with pure Mg₃(PO₄)₂ scaffolds, strontium doped scaffolds had excellent comprehensive properties, which explain that Sr_3−xMg _x(PO₄)₂ composite scaffolds can be used for bone tissue engineering.

Keywords

3D printing / magnesium phosphatase / strontium / porous scaffolds / degradability

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