Computational investigation of a 3D-printed osteochondral interface scaffold with comprehensive interfacial mechanical properties
Kaicheng Yu , Qiang Gao , Yanling Mi , Yifeng Yao , Zexue Lin , Min Zhu , Peng Zhang , Swee Leong Sing , Lihua Lu
International Journal of Bioprinting ›› 2025, Vol. 11 ›› Issue (2) : 353 -369.
Computational investigation of a 3D-printed osteochondral interface scaffold with comprehensive interfacial mechanical properties
Osteoarthritis is a highly prevalent rheumatic musculoskeletal disorder that often results in both physiological dysfunction and psychological distress. Although many tissue engineering approaches have been proposed for tissue regeneration, the mechanical properties of many scaffolds remain insufficient to fully meet the mechanical demands within the joint. This paper presents a computational investigation and structural design for creating an osteochondral interface scaffold using extrusion-based 3D printing. A finite element method-based mechanics simulation model was employed to evaluate the effects of load-bearing forces on various scaffold designs, enabling the analysis of stress distribution within the biomimetic osteochondral interface. Several structures of osteochondral interface scaffolds were fabricated, demonstrating controllable mechanical properties. The proposed biomimetic osteochondral interface manifested comprehensive mechanical performance, with bonding strength, compressive strength, and shear strength reaching 128, 277, and 276 kPa, respectively. Our research can benefit the future development in tissue engineering and regenerative medicine.
Computational modeling / Extrusion-based 3D printing / Mechanical properties / Osteochondral interface
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