FedViTBloc: Secure and privacy-enhanced medical image analysis with federated vision transformer and blockchain

Gabriel Chukwunonso Amaizu , Akshita Maradapu Vera Venkata Sai , Sanjay Bhardwaj , Dong-Seong Kim , Madhuri Siddula , Yingshu Li

High-Confidence Computing ›› 2025, Vol. 5 ›› Issue (3) : 100302

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High-Confidence Computing ›› 2025, Vol. 5 ›› Issue (3) : 100302 DOI: 10.1016/j.hcc.2025.100302
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FedViTBloc: Secure and privacy-enhanced medical image analysis with federated vision transformer and blockchain

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Abstract

The increasing prevalence of cancer necessitates advanced methodologies for early detection and diagnosis. Early intervention is crucial for improving patient outcomes and reducing the overall burden on healthcare systems. Traditional centralized methods of medical image analysis pose significant risks to patient privacy and data security, as they require the aggregation of sensitive information in a single location. Furthermore, these methods often suffer from limitations related to data diversity and scalability, hindering the development of universally robust diagnostic models. Recent advancements in machine learning, particularly deep learning, have shown promise in enhancing medical image analysis. However, the need to access large and diverse datasets for training these models introduces challenges in maintaining patient confidentiality and adhering to strict data protection regulations. This paper introduces FedViTBloc, a secure and privacy-enhanced framework for medical image analysis utilizing Federated Learning (FL) combined with Vision Transformers (ViT) and blockchain technology. The proposed system ensures patient data privacy and security through fully homomorphic encryption and differential privacy techniques. By employing a decentralized FL approach, multiple medical institutions can collaboratively train a robust deep-learning model without sharing raw data. Blockchain integration further enhances the security and trustworthiness of the FL process by managing client registration and ensuring secure onboarding of participants. Experimental results demonstrate the effectiveness of FedViTBloc in medical image analysis while maintaining stringent privacy standards, achieving 67% accuracy and reducing loss below 2 across 10 clients, ensuring scalability and robustness.

Keywords

AI / Blockchain / Decentralized / Federated Learning / Medical images / Machine Learning / ViT

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Gabriel Chukwunonso Amaizu, Akshita Maradapu Vera Venkata Sai, Sanjay Bhardwaj, Dong-Seong Kim, Madhuri Siddula, Yingshu Li. FedViTBloc: Secure and privacy-enhanced medical image analysis with federated vision transformer and blockchain. High-Confidence Computing, 2025, 5(3): 100302 DOI:10.1016/j.hcc.2025.100302

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CRediT authorship contribution statement

Gabriel Chukwunonso Amaizu: Writing - review & editing, Writing - original draft, Visualization, Validation, Software, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Akshita Maradapu Vera Venkata Sai: Writing - review & editing, Supervision, Funding acquisition. Sanjay Bhard-waj: Supervision, Investigation. Dong-Seong Kim: Supervision. Madhuri Siddula: Funding acquisition. Yingshu Li: Funding acquisition.

Declaration of Generative AI and AI-assisted technologies in the writing process

During the preparation of this work, the authors used chatGPT in order to perform English corrections. After using this tool/service, the authors reviewed and edited the content as needed and take(s) full responsibility for the content of the publication.

Declaration of competing interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Acknowledgments

This research was supported by the Ministry of Science and ICT, Korea, under the Grand IT Research Center support program (IITP-2022-2020-0-01612) supervised by the IITP (Institute for Information & Communications Technology Planning & Evaluation) and Priority Research Centers Program through the National Research Fund (NRF) Korea funded by the Ministry of Education, Science and Technology, South Korea (2018R1A6A1A03024003). This research was also supported in part by National Science Foundation (NSF) of USA (2200673) and the Office of Sponsored Programs & Research Seed Funding Program at Towson University, United States.

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