Circadian rhythms in Alzheimer’s disease: A molecular clock worth watching

Conflict of interest

The author declares no conflict of interest.

References

[1] Hippius H, Neundorfer G. The discovery of Alzheimer’s disease. Dialogues Clin Neurosci. 2003; 5(1):101-108. doi: 10.31887/DCNS.2003.5.1/hhippius

[2] Korczyn AD, Grinberg LT. Is Alzheimer disease a disease? Nat Rev Neurol. 2024; 20(4):245-251. doi: 10.1038/s41582-024-00940-4

[3] Hoyt KR, Obrietan K. Circadian clocks, cognition, and Alzheimer’s disease: Synaptic mechanisms, signaling effectors, and chronotherapeutics. Mol Neurodegener. 2022; 17(1):35. doi: 10.1186/s13024-022-00537-9

[4] Gibson M. A systematic review of the relationship between night shift work and oxidative stress. Chronobiol Int. 2022; 39(2):285-298. doi: 10.1080/07420528.2021.1989446

[5] Gonzales PNG, Villaraza SG, Rosa JCD. The association between sleep and Alzheimer’s disease: A systematic review. Dement Neuropsychol. 2024;18:e20230049. doi: 10.1590/1980-5764-DN-2023-0049

[6] Morrone CD, Raghuraman R, Hussaini SA, Yu WH. Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease. Mol Neurodegener. 2023; 18(1):27. doi: 10.1186/s13024-023-00617-4

[7] Son G, Neylan TC, Grinberg LT. Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: Evidence from human studies and animal models. Mol Neurodegener. 2024; 19(1):4. doi: 10.1186/s13024-023-00695-4

[8] Mueed Z, Rai PK, Kamal MA, Poddar NK. Decoding the inter-relationship between sleep disorders and Alzheimer’s disease pathogenesis. CNS Neurol Disord Drug Targets. 2021; 20(8):723-735. doi: 10.2174/1871527319666200903161249

[9] Carpi M, Mercuri NB, Liguori C. Orexin receptor antagonists for the prevention and treatment of Alzheimer’s disease and associated sleep disorders. Drugs. 2024; 84(11):1365-1378. doi: 10.1007/s40265-024-02096-3

[10] Currenti W, Godos J, Castellano S, et al. Time restricted feeding and mental health: A review of possible mechanisms on affective and cognitive disorders. Int J Food Sci Nutr. 2021; 72(6):723-733. doi: 10.1080/09637486.2020.1866504

[11] Mehramiz M, Porter T, O’Brien EK, Rainey-Smith SR, Laws SM. A potential role for sirtuin-1 in Alzheimer’s disease: Reviewing the biological and environmental evidence. J Alzheimers Dis Rep. 2023; 7(1):823-843. doi: 10.3233/ADR-220088

[12] Sharma A, Lee S, Kim H, Yoon H, Ha S, Kang SU. Molecular Crosstalk Between Circadian Rhythmicity and the Development of Neurodegenerative Disorders. Front Neurosci. 2020;14:844. doi: 10.3389/fnins.2020.00844