Bioinformatics and next generation sequencing data analysis to identify key genes and pathways influencing in Parkinson's disease

Abstract

Parkinson's disease (PD) is the most commonly diagnosed neurodegenerative disorder Identification of novel prognostic and pathogenesis biomarkers plays a pivotal role in the management of the PD. Next generation sequencing dataset from the gene expression omnibus database were used to identify differentially expressed genes (DEGs) in PD. Gene ontology (GO) and REACTOME pathway enrichment analyses were performed to elucidate the functional roles of the DEGs. Protein–protein interaction (PPI), modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network were established. The receiver operating characteristic curve (ROC) analysis was used to explore the diagnostic values of hub genes in PD. In total, 957 DEGs were identified, of which 478 were up regulated genes and 479 were down regulated genes. GO and pathway enrichment analysis results revealed that the up regulated genes were mainly enriched in nervous system development, cell junction, transporter activity and neuronal system, whereas down regulated genes were mainly enriched in response to stimulus, cell periphery, identical protein binding and immune system. The top hub genes in the constructed PPI network, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network were OTUB1, PPP2R1A, AP2M1, PIN1, USP11, CDK2, IQGAP1, NEDD4, VIM and CDK1. Furthermore, ROC analysis showed that hub genes were having good diagnostic values. We identified a series of essential genes along with the pathways that were most closely related with PD initiation and progression. Our results provide a more detailed molecular mechanism for the advancement of PD, shedding light on the potential biomarkers and therapeutic targets.

Keywords

Parkinson's disease / MicroRNAs / Hub gene / Bioinformatics analysis / Biomarkers / Biological Sciences / Biochemistry and Cell Biology / Genetics

References

[1] Abdel RasolHA, HelmyH, AzizMA. Serum complement factor H and Tyr402 His gene polymorphism among Egyptians with multiple sclerosis. Neurological Research, 2015, 3710845-852.

[2] Abou JamraR, GobinaCM, BeckerT, GeorgiA, SchulzeTG, SchmaelC, CichonS, ProppingP, RietschelM, NöthenMM, et al. . Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder. Psychiatric Genetics, 2008, 184199-203.

[3] AfloukY, InoubliO, SaoudH, ZaafraneF, GahaL, Bel Hadj JradB. Association between TLR2 polymorphisms (- 196–174 Ins/Del, R677W, R753Q, and P631H) and schizophrenia in a Tunisian population. Immunologic Research, 2021, 696541-552.

[4] AguirreCA, Concetta MoraleM, PengQ, Sanchez-AlavezM, Cintrón-ColónR, FengK, FazelpourS, MaherP, ContiB. Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress. Brain, Behavior, and Immunity, 2020, 88: 920-924.

[5] AhmadSF, NadeemA, AnsariMA, BakheetSA, Al-AyadhiLY, AttiaSM. Upregulation of IL-9 and JAK-STAT signaling pathway in children with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 79Pt B472-480.

[6] AhnEH, KangSS, QiQ, LiuX, YeK. Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 2020, 1173924503-24513.

[7] AichholzerF, KlafkiHW, OgorekI, VogelgsangJ, WiltfangJ, ScherbaumN, WeggenS, WirthsO. Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer's disease. Alzheimer's Research and Therapy, 2021, 13194.

[8] Al DhaibaniMA, El-HattabAW, HolroydKB, Orthmann-MurphyJ, LarsonVA, SiddiquiKA, SzolicsM, SchiessN. Novel mutation in the KCNJ10 gene in three siblings with seizures, ataxia and no electrolyte abnormalities. Journal of Neurogenetics, 2018, 3211-5.

[9] Al-EitanLN, Al-DalalahIM, AljamalHA. Effects of GRM4, SCN2A and SCN3B polymorphisms on antiepileptic drugs responsiveness and epilepsy susceptibility. Saudi Pharmaceutical Journal, 2019, 275731-737.

[10] Alanis-LobatoG, Andrade-NavarroMA, SchaeferMH. HIPPIE v2.0: enhancing meaningfulness and reliability of protein-protein interaction networks. Nucleic Acids Research, 2017, 45D1D408-D414.

[11] AlexoudiA, ZachakiS, StavropoulouC, GavriliS, SpiliopoulouC, PapadodimaS, KarageorgiouCE, SambaniC. Possible implication of GSTP1 and NQO1 polymorphisms on natalizumab response in multiple sclerosis. Annals of Clinical and Laboratory Science, 2016, 466586-591

[12] AlhowikanAM. Activity-regulated cytoskeleton-associated protein dysfunction may contribute to memory disorder and earlier detection of autism spectrum disorders. Medical Principles and Practice, 2016, 254350-354.

[13] AminyavariS, ZahmatkeshM, KhodagholiF, SanatiM. Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5. Peptides, 2019, 118. 170102

[14] Ammal KaideryN, AhujaM, ThomasB. Crosstalk between Nrf2 signaling and mitochondrial function in Parkinson's disease. Molecular and Cellular Neuroscience, 2019, 101. 103413

[15] AnanthaJ, GouldingSR, TubolyE, O'MahonyAG, MoloneyGM, LomanseyG, McCarthyCM, CollinsLM, SullivanAM, O'KeeffeGW. NME1 protects against neurotoxin-, α-synuclein- and LRRK2-induced neurite degeneration in cell models of Parkinson's disease. Molecular Neurobiology, 2022, 59161-76.

[16] AncínI, BarabashA, Vázquez-ÁlvarezB, SantosJL, Sánchez-MorlaE, MartínezJL, AparicioA, PeláezJC, DíazJA. Evidence for association of the non-duplicated region of CHRNA7 gene with bipolar disorder but not with Schizophrenia. Psychiatric Genetics, 2010, 206289-297.

[17] AngelopoulouE, PaudelYN, ShaikhMF, PiperiC. Fractalkine (CX3CL1) signaling and neuroinflammation in Parkinson's disease: Potential clinical and therapeutic implications. Pharmacological Research, 2020, 158. 104930

[18] ArosioA, SalaG, Rodriguez-MenendezV, GranaD, GerardiF, LunettaC, FerrareseC, TremolizzoL. MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients. Molecular and Cellular Neuroscience , 2016, 74: 10-17.

[19] AshbrookDG, CahillS, HagerR. A cross-species systems genetics analysis links APBB1IP as a candidate for schizophrenia and prepulse inhibition. Frontiers in Behavioral Neuroscience, 2019, 13: 266.

[20] AshrafA, AshtonNJ, ChatterjeeP, GoozeeK, ShenK, FrippJ, AmesD, RoweC, MastersCL, VillemagneV, et al. . Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer's disease pathology. Alzheimer's Research and Therapy, 2020, 12172.

[21] AssenovY, RamírezF, SchelhornSE, LengauerT, AlbrechtM. Computing topological parameters of biological networks. Bioinformatics, 2008, 242282-284.

[22] AtakhorramiM, Rahimi-AliabadiS, JamshidiJ, MoslemiE, MovafaghA, OhadiM, MirabzadehA, EmamalizadehB, GhaediH, GholipourF, et al. . A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder. Journal of Neural Transmission (Vienna), 2016, 1233323-328.

[23] AzimiG, RanjbaranF, Arsang-JangS, Ghafouri-FardS, MazdehM, SayadA, TaheriM. Upregulation of VEGF-A and correlation between VEGF-A and FLT-1 expressions in Iranian multiple sclerosis patients. Neurological Sciences, 2020, 4161459-1465.

[24] BacchelliE, BattagliaA, CameliC, LomartireS, TancrediR, ThomsonS, SutcliffeJS, MaestriniE. Analysis of CHRNA7 rare variants in autism spectrum disorder susceptibility. American Journal of Medical Genetics. Part A, 2015, 167A4715-723.

[25] BailusBJ, ScheelerSM, SimonsJ, SanchezMA, TshilengeKT, Creus-MuncunillJ, NaphadeS, Lopez-RamirezA, ZhangN, Lakshika MadushaniK, et al. . Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy, 2021, 17124119-4140.

[26] BajajNP. Cyclin-dependent kinase-5 (CDK5) and amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2000, 15319-327.

[27] BakanidzeG, RoinishviliM, ChkoniaE, KitzrowW, RichterS, NeumannK, HerzogMH, BrandA, PulsI. Association of the nicotinic receptor α7 subunit gene (CHRNA7) with schizophrenia and visual backward masking. Frontiers in Psychiatry, 2013, 4: 133.

[28] BalanS, YamadaK, IwayamaY, ToyotaT, OhnishiT, MaekawaM, ToyoshimaM, IwataY, SuzukiK, KikuchiM, et al. . Lack of association of EGR2 variants with bipolar disorder in Japanese population. Gene, 2013, 5262246-250.

[29] BaltusTHL, MorelliNR, de FariasCC, TrugiloKP, OkuyamaNCM, de OliveiraKB, de MeloLB, SmailiSM, BarbosaDS. Association of -94 ATTG insertion/deletion NFkB1 and c.*126G>A NFkBIA genetic polymorphisms with oxidative and nitrosative stress biomarkers in Brazilian subjects with Parkinson's Disease. Neuroscience Letters, 2021, 740: 135487.

[30] BaronBW, PytelP. Expression pattern of the BCL6 and ITM2B proteins in normal human brains and in Alzheimer disease. Applied Immunohistochemistry and Molecular Morphology, 2017, 257489-496.

[31] BasivireddyJ, SomvanshiRK, RomeroIA, WekslerBB, CouraudPO, OgerJ, KumarU. Somatostatin preserved blood brain barrier against cytokine induced alterations: Possible role in multiple sclerosis. Biochemical Pharmacology, 2013, 864497-507.

[32] BaumannK, MandelkowEM, BiernatJ, Piwnica-WormsH, MandelkowE. Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Letters, 1993, 3363417-424.

[33] BehanAT, ByrneC, DunnMJ, CagneyG, CotterDR. Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression. Molecular Psychiatry, 2009, 146601-613.

[34] BeitzJM. Parkinson's disease: A review. Frontiers in Bioscience (Scholar Edition), 2014, 6: 65-74.

[35] BennettAOMR. Stress and anxiety in schizophrenia and depression: Glucocorticoids, corticotropin-releasing hormone and synapse regression. Australian and New Zealand Journal of Psychiatry, 2008, 4212995-1002.

[36] BergamaschiL, BanM, LeoneMA, SawcerSJ, D'AlfonsoS. No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis. Journal of Neuroimmunology, 2010, 2211–2112-114.

[37] BertoglioD, VerhaegheJ, WyffelsL, MirandaA, StroobantsS, MrzljakL, DominguezC, SkinbjergM, BardJ, LiuL, et al. . Synaptic vesicle glycoprotein 2A is affected in the CNS of Huntington's Disease mice and post-mortem human HD brain. Journal of Nuclear Medicine, 2021.

[38] BeyerK, IspiertoL, LatorreP, TolosaE, ArizaA. Alpha- and beta-synuclein expression in Parkinson disease with and without dementia. Journal of the Neurological Sciences, 2011, 3101–2112-117.

[39] BiXJ, HuL, QiaoDD, HanC, SunMM, CuiKY, WangLN, YangLM, LiuLF, ChenZY. Evidence for an interaction between NEDD4 and childhood trauma on clinical characters of schizophrenia with family history of psychosis. Frontiers in Psychiatry, 2021, 12. 608231

[40] BigalkeB, SchreitmüllerB, SopovaK, PaulA, StranskyE, GawazM, StellosK, LaskeC. Adipocytokines and CD34 progenitor cells in Alzheimer's disease. PLoS ONE, 2011, 65. e20286

[41] BillingsleyKJ, Bandres-CigaS, Saez-AtienzarS, SingletonAB. Genetic risk factors in Parkinson's disease. Cell and Tissue Research, 2018, 37319-20.

[42] BlauthK, ZhangX, ChopraM, RoganS, Markovic-PleseS. The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis. Clinical Immunology, 2015, 1572121-132.

[43] BlennowK, BogdanovicN, HeiligM, GrenfeldtB, KarlssonI, DavidssonP. Reduction of the synaptic protein rab3a in the thalamus and connecting brain regions in post-mortem schizophrenic brains. Journal of Neural Transmission (Vienna), 2000, 1078–91085-1097.

[44] BoikoAS, IvanovaSA, PozhidaevIV, FreidinMB, OsmanovaDZ, FedorenkoOY, SemkeAV, BokhanNA, WilffertB, LoonenAJM. Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors. The World Journal of Biological Psychiatry, 2020, 21172-77.

[45] BondulichMK, JolinonN, OsborneGF, SmithEJ, RattrayI, NeuederA, SathasivamK, AhmedM, AliN, BenjaminAC, et al. . Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice. Science Report, 2017, 7114275.

[46] BosoM, EmanueleE, MinorettiP, ArraM, PolitiP, Ucelli di NemiS, BaraleF. Alterations of circulating endogenous secretory RAGE and S100A9 levels indicating dysfunction of the AGE-RAGE axis in autism. Neuroscience Letter, 2006, 4103169-173.

[47] BotteroV, SantiagoJA, PotashkinJA. PTPRC expression in blood is downregulated in parkinson's and progressive supranuclear palsy disorders. Journal of Parkinson's Disease, 2018, 84529-537.

[48] BourelJ, PlancheV, DubourdieuN, OliveiraA, SéréA, DucourneauEG, TibleM, MaitreM, Lesté-LasserreT, NadjarA, et al. . Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis. Neurobiology of Diseases, 2021, 160. 105533

[49] BourinM, MalingeM, VasarE, BradwejnJ. Two faces of cholecystokinin: Anxiety and schizophrenia. Fundamental and Clinical Pharmacology, 1996, 102116-126.

[50] BreuillardD, LeunenD, ChemalyN, AuclairL, PinardJM, KaminskaA, DesguerreI, OussL, NabboutR. Autism spectrum disorder phenotype and intellectual disability in females with epilepsy and PCDH-19 mutations. Epilepsy and Behavior, 2016, 60: 75-80.

[51] BryldE, ZeebergI, GjerrisA, WerdelinL, RehfeldJF. Increased cerebrospinal fluid concentrations of C- but not N-terminal cholecystokinin fragments in multiple sclerosis. Brain Research, 1987, 4092364-366.

[52] BudgeKM, NealML, RichardsonJR, SafadiFF. Glycoprotein NMB: An emerging role in neurodegenerative disease. Molecular Neurobiology, 2018, 5565167-5176.

[53] BurgalettoC, PlataniaCBM, Di BenedettoG, MunafòA, GiurdanellaG, FedericoC, CaltabianoR, SacconeS, ContiF, BernardiniR, et al. . Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer's disease. Cell Death and Disease, 2021, 1210905.

[54] BusseS, BernsteinHG, BusseM, BielauH, BrischR, MawrinC, MüllerS, SarnyaiZ, GosT, BogertsB, et al. . Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: A potential link to impaired growth factor signaling and energy homeostasis. European Archives of Psychiatry and Clinical Neuroscience, 2012, 2625365-374.

[55] ByrneLM, RodriguesFB, JohnsonEB, De VitaE, BlennowK, ScahillR, ZetterbergH, HeslegraveA, WildEJ. Cerebrospinal fluid neurogranin and TREM2 in Huntington's disease. Science and Reports, 2018, 814260.

[56] Cadieux-DionM, MeneghiniS, VillaC, ToffaDH, WickstromR, BouthillierA, SandvikU, GustavssonB, MohamedI, CossetteP, et al. . Variants in CHRNB2 and CHRNA4 identified in patients with insular epilepsy. Canadian Journal of Neurological Sciences, 2020, 476800-809.

[57] CamachoJ, RábanoA, MarazuelaP, Bonaterra-PastraA, SernaG, MolinéT, RamónY, CajalS, Martínez-SáezE, Hernández-GuillamonM. Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer's disease. Brain Pathology, 2022, 321e13016.

[58] CampoloM, FilipponeA, BiondoC, MancusoG, CasiliG, LanzaM, CuzzocreaS, EspositoE, PaternitiI. TLR7/8 in the pathogenesis of Parkinson's disease. International Journal of Molecular Sciences, 2020, 21249384.

[59] CantrupR, SathananthamK, RushlowWJ, RajakumarN. Chronic hyperdopaminergic activity of schizophrenia is associated with increased ΔFosB levels and cdk-5 signaling in the nucleus accumbens. Neuroscience, 2012, 222: 124-135.

[60] CaputiV, GironMC. Microbiome-gut-brain axis and toll-like receptors in Parkinson's disease. International Journal of Molecular Sciences, 2018, 1961689.

[61] CardamoneG, ParaboschiEM, SoldàG, DugaS, SaarelaJ, AsseltaR. Genetic association and altered gene expression of CYBB in multiple sclerosis patients. Biomedicines, 2018, 64117.

[62] CarliniV, VerduciI, CianciF, CannavaleG, FenoglioC, GalimbertiD, MazzantiM. CLIC1 protein accumulates in circulating monocyte membrane during neurodegeneration. International Journal of Molecular Sciences, 2020, 2141484.

[63] CarlsonNG, HillKE, TsunodaI, FujinamiRS, RoseJW. The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: Implications for multiple sclerosis. Journal of Neuroimmunology, 2006, 1741–221-31.

[64] CarnemollaA, MichelazziS, AgostoniE. PIN1 Modulates huntingtin levels and aggregate accumulation: An in vitro model. Frontiers in Cellular Neuroscience, 2017, 11: 121.

[65] CastellanosKJ, GagyiE, KormosB, Valyi-NagyK, VorosA, ShuklaD, HorvathS, SlavinKV, Valyi-NagyT. Increased axonal expression of nectin-1 in multiple sclerosis plaques. Neurological Sciences, 2013, 344465-469.

[66] ChameraK, KotarskaK, Szuster-GłuszczakM, TrojanE, SkórkowskaA, PomiernyB, KrzyżanowskaW, BryniarskaN, Basta-KaimA. The prenatal challenge with lipopolysaccharide and polyinosinic:Polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: A link to schizophrenia-like behaviours. Journal of Neuroinflammation, 2020, 171247.

[67] ChandlerD, DragovićM, CooperM, BadcockJC, MullinBH, FaulknerD, WilsonSG, HallmayerJ, HowellS, RockD, et al. . Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia. American Journal of Medical Genetics. Part b, Neuropsychiatric Genetics, 2010, 153B2428-437.

[68] ChangKH, ChenCM, ChenYC, FungHC, WuYR. Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B are not associated with Parkinson's disease in Taiwan. Parkinsons Dis., 2019, 2019: 3489638.

[69] ChangKH, WuYR, ChenYC, WuHC, ChenCM. Association between CSF1 and CSF1R polymorphisms and Parkinson's disease in Taiwan. Journal of Clinical Medicine, 2019, 8101529.

[70] ChatawayJ, SawcerS, ShermanD, HobartM, FernieB, CoradduF, FeakesR, BroadleyS, GrayJ, JonesHB, et al. . No evidence for association of multiple sclerosis with the complement factors C6 and C7. Journal of Neuroimmunology, 1999, 991150-156.

[71] ChaumetteB, FerrafiatV, AmbalavananA, GoldenbergA, Dionne-LaporteA, SpiegelmanD, DionPA, GerardinP, LaurentC, CohenD, et al. . Missense variants in ATP1A3 and FXYD gene family are associated with childhood-onset schizophrenia. Molecular Psychiatry, 2020, 254821-830.

[72] ChenJ, ChenJ, XuY, ChengP, YuS, FuY, DuY. Retinol-binding protein 4 in combination with lipids to predict the regression phenomenon of autism spectrum disorders. Lipids in Health and Disease, 2021, 20193.

[73] ChenMM, HuZL, DingJH, DuRH, HuG. Astrocytic Kir6.1 deletion aggravates neurodegeneration in the lipopolysaccharide-induced mouse model of Parkinson's disease via astrocyte-neuron cross talk through complement C3–C3R signaling. Brain, Behavior, and Immunity, 2021, 95: 310-320.

[74] ChenPY, HuangMC, ChiuCC, LiuHC, LuML, ChenCH. Association of plasma retinol-binding protein-4, adiponectin, and high molecular weight adiponectin with metabolic adversities in patients with schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011, 3581927-1932.

[75] ChenCY, LiuHY, HsuehYP. TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology. EMBO Reports, 2017, 181169-183.

[76] ChengL, ChenL, WeiX, WangY, RenZ, ZengS, ZhangX, WenH, GaoC, LiuH. NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. Journal of Neuroinflammation, 2018, 151243.

[77] ChengC, HouY, ZhangZ, WangY, LuL, ZhangL, JiangP, GaoS, FangQ, ZhuC, et al. . Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in mice. Journal of Genetics and Genomics, 2021, 484324-332.

[78] ChengX, XuS, ZhangC, QinK, YanJ, ShaoX. The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models. Biochemical and Biophysical Research Communications, 2020, 5223647-654.

[79] CherubiniM, PuigdellívolM, AlberchJ, GinésS. Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease. Biochimica Et Biophysica Acta, 2015, 185210 Pt A2145-2160.

[80] ChhetriJ, KingAE, GuevenN. Alzheimer's Disease and NQO1: Is there a Link?. Current Alzheimer Research, 2018, 15156-66.

[81] ChittiprolS, VenkatasubramanianG, NeelakantacharN, ReddyNA, ShettyKT, GangadharBN. Longitudinal study of beta2-microglobulin abnormalities in schizophrenia. International Immunopharmacology, 2009, 9101215-1217.

[82] ChuangYA, HuTM, ChenCH, HsuSH, TsaiHY, ChengMC. Rare mutations and hypermethylation of the ARC gene associated with schizophrenia. Schizophrenia Research, 2016, 1762–3106-113.

[83] CiminoPJ, YangY, LiX, HemingwayJF, CherneMK, KhademiSB, FukuiY, MontineKS, MontineTJ, KeeneCD. Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease. Experimental and Molecular Pathology, 2013, 942366-371.

[84] CloughE, BarrettT. The gene expression omnibus database. Methods in Molecular Biology, 2016, 1418: 93-110.

[85] Coenen-StassAML, MagenI, BrooksT, Ben-DovIZ, GreensmithL, HornsteinE, FrattaP. Evaluation of methodologies for microRNA biomarker detection by next generation sequencing. RNA Biology, 2018, 1581133-1145.

[86] Cohn-HokkePE, WongTH, RizzuP, BreedveldG, van der FlierWM, ScheltensP, BaasF, HeutinkP, Meijers-HeijboerEJ, van SwietenJC, et al. . Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort. Journal of Neurology, 2014, 261112085-2092.

[87] ColamatteoA, MaggioliE, Azevedo LoiolaR, Hamid SheikhM, CalìG, BruzzeseD, ManiscalcoGT, CentonzeD, ButtariF, LanzilloR, et al. . Reduced annexin A1 expression associates with disease severity and inflammation in multiple sclerosis patients. The Journal of Immunology, 2019, 20371753-1765.

[88] CookLJ, HoLW, TaylorAE, BrayneC, EvansJG, XuerebJ, CairnsNJ, PritchardA, LemmonH, MannD, et al. . Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease. Neuroscience Letters, 2004, 3582142-146.

[89] CorreiaCT, ConceiçãoIC, OliveiraB, CoelhoJ, SousaI, SequeiraAF, AlmeidaJ, CaféC, DuqueF, MougaS, et al. . Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders. Mol Autism., 2014, 5128.

[90] CorsiMM, LicastroF, PorcelliniE, DogliottiG, GallieraE, LamontJL, InnocenziPJ, FitzgeraldSP. Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: Relationship with neuro-degeneration. Biogerontology, 2011, 125451-454.

[91] CountsSE, MufsonEJ. Regulator of cell cycle (RGCC) expression during the progression of Alzheimer's disease. Cell Transplantation, 2017, 264693-702.

[92] CoutelierM, BlesneacI, MonteilA, MoninML, AndoK, MundwillerE, BruscoA, Le BerI, AnheimM, CastriotoA. A recurrent mutation in CACNA1G alters Cav31 T-type calcium-channel conduction and causes autosomal-dominant cerebellar ataxia. American Journal of Human Genetics, 2015, 975726-737.

[93] CunninghamS, O'DohertyC, PattersonC, McDonnellG, HawkinsS, MarrosuMG, VandenbroeckK. The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. Journal of Neuroimmunology, 2007, 1831–2208-213.

[94] Dalla VecchiaE, MortimerN, PalladinoVS, Kittel-SchneiderS, LeschKP, ReifA, SchenckA, NortonWHJ. Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: Lessons from CNTNAP2, ADGRL3, and PARK2. Psychiatric Genetics, 2019, 2911-17.

[95] DanieleSG, BéraudD, DavenportC, ChengK, YinH, Maguire-ZeissKA. Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders. Science Signaling, 2015, 8376ra45.

[96] DarvishH, AzconaLJ, TaghaviS, FirouzabadiSG, TafakhoriA, AlehabibE, MohajeraniF, ZardadiS, Paisán-RuizC. ANXA1 with anti-inflammatory properties might contribute to parkinsonism. Annals of Neurology, 2021, 902319-323.

[97] DaskalakisNP, BinderEB. Schizophrenia in the spectrum of gene-stress interactions: The FKBP5 example. Schizophrenia Bulletin, 2015, 412323-329.

[98] DavidssonP, BogdanovicN, LannfeltL, BlennowK. Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 2001, 124243-250.

[99] DengH, GuS, JankovicJ. LINGO1 variants in essential tremor and Parkinson's disease. Acta Neurologica Scandinavica, 2012, 12511-7.

[100] de JongJO, LlapashticaC, GenestineM, StraussK, ProvenzanoF, SunY, ZhuH, CorteseGP, BrunduF, BrigattiKW, et al. . Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder. Nature Communications, 2021, 1214087.

[101] DenicA, PirkoI, WootlaB, BieberA, MacuraS, RodriguezM. Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis. Brain Pathology, 2012, 225698-708.

[102] Di MaioA, De RosaA, PelucchiS, GarofaloM, MarcianoB, NuzzoT, GardoniF, IsidoriAM, Di LucaM, ErricoF, et al. . Analysis of mRNA and protein levels of CAP2, DLG1 and ADAM10 genes in post-mortem brain of schizophrenia, Parkinson's and Alzheimer's disease patients. International Journal of Molecular Sciences, 2022, 2331539.

[103] DinhE, RivalT, CarrierA, AsfogoN, CortiO, MelonC, SalinP, LortetS, Kerkerian-LeGL. TP53INP1 exerts neuroprotection under ageing and Parkinson's disease-related stress condition. Cell Death and Disease, 2021, 125460.

[104] DongY, XiongJ, JiL, XueX. MiR-421 aggravates neurotoxicity and promotes cell death in Parkinson's disease models by directly targeting MEF2D. Neurochemical Research, 2021, 462299-308.

[105] DonninelliG, Saraf-SinikI, MazziottiV, CaponeA, GrassoMG, BattistiniL, ReynoldsR, MagliozziR, VolpeE. Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain. Journal of Neuroinflammation, 2020, 171149.

[106] DulewiczM, Kulczyńska-PrzybikA, SłowikA, BorawskaR, MroczkoB. Neurogranin and neuronal pentraxin receptor as synaptic dysfunction biomarkers in Alzheimer's disease. Journal of Clinical Medicine, 2021, 10194575.

[107] EbbertMTW, RossCA, PregentLJ, LankRJ, ZhangC, KatzmanRB, Jansen-WestK, SongY, da RochaEL, PalmucciC, et al. . Conserved DNA methylation combined with differential frontal cortex and cerebellar expression distinguishes C9orf72-associated and sporadic ALS, and implicates SERPINA1 in disease. Acta Neuropathologica, 2017, 1345715-728.

[108] EjlerskovP, HultbergJG, WangJ, CarlssonR, AmbjørnM, KussM, LiuY, PorcuG, KolkovaK, Friis RundstenC, et al. . Lack of neuronal IFN-β-IFNAR causes lewy body- and Parkinson's disease-like dementia. Cell, 2015, 1632324-339.

[109] EmilssonL, SaetreP, JazinE. Low mRNA levels of RGS4 splice variants in Alzheimer's disease: Association between a rare haplotype and decreased mRNA expression. Synapse (New York, NY), 2006, 593173-176.

[110] EnevoldC, OturaiAB, SørensenPS, RyderLP, Koch-HenriksenN, BendtzenK. Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1. Journal of Neuroimmunology, 2009, 2121–2125-131.

[111] FabregatA, JupeS, MatthewsL, SidiropoulosK, GillespieM, GarapatiP, HawR, JassalB, KorningerF, MayB, et al. . The reactome pathway knowledgebase. Nucleic Acids Research, 2018, 46D1D649-D655.

[112] FaganK, CriderA, AhmedAO, PillaiA. Complement C3 expression is decreased in autism spectrum disorder subjects and contributes to behavioral deficits in rodents. Molecular Neuropsychiatry, 2017, 3119-27.

[113] FagianiF, GovoniS, RacchiM, LanniC. The Peptidyl-prolyl Isomerase Pin1 in Neuronal Signaling: From Neurodevelopment to Neurodegeneration. Molecular Neurobiology, 2021, 5831062-1073.

[114] FanQ, HeW, GayenM, BenoitMR, LuoX, HuX, YanR. Activated CX3CL1/Smad2 signals prevent neuronal loss and Alzheimer's tau pathology-mediated cognitive dysfunction. Journal of Neuroscience, 2020, 4051133-1144.

[115] FanY, XiaJ. miRNet-functional analysis and visual exploration of miRNA-target interactions in a network context. Methods in Molecular Biology, 2018, 1819: 215-233.

[116] FangHS, WangCC, ChaoCY, FanWL, SuSC, WuYR. Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan. Journal of the Formosan Medical Association, 2021, S0929–66462100296-305.

[117] Fani MalekiA, CisbaniG, LaflammeN, PrefontaineP, PlanteMM, BaillargeonJ, RangachariM, GosselinJ, RivestS. Selective immunomodulatory and neuroprotective effects of a NOD2 receptor agonist on mouse models of multiple sclerosis. Neurotherapeutics, 2021, 182889-904.

[118] FatemiSH, ReutimanTJ, FolsomTD, RustanOG, RooneyRJ, ThurasPD. Downregulation of GABAA receptor protein subunits α6, β2, δ, ε, γ2, θ, and ρ2 in superior frontal cortex of subjects with autism. Journal of Autism and Developmental Disorders, 2014, 4481833-1845.

[119] Fatjó-VilasM, PratsC, Pomarol-ClotetE, LázaroL, MorenoC, González-OrtegaI, Lera-MiguelS, MiretS, MuñozMJ, IbáñezI, et al. . Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning. The World Journal of Biological Psychiatry, 2016, 172129-139.

[120] Fernandez-EnrightF, AndrewsJL. Lingo-1: A novel target in therapy for Alzheimer's disease?. Neural Regeneration Research, 2016, 11188-89.

[121] Fernandez-EnrightF, AndrewsJL, NewellKA, PantelisC, HuangXF. Novel implications of Lingo-1 and its signaling partners in schizophrenia. Translational Psychiatry, 2014, 41. e348

[122] FesselJ. If ineffective levels of transforming growth factors and their receptor account for old age being a risk factor for Alzheimer's disease, then increasing TGFBR2 might be therapeutic. Alzheimers Dement (NY., 2020, 61. e12019

[123] FlemingSM, DavisA, SimonsE. Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies. Neuropharmacology, 2022, 202. 108870

[124] Flores-SotoME, Corona-AngelesJA, Tejeda-MartinezAR, Flores-GuzmanPA, Luna-MujicaI, Chaparro-HuertaV, Viveros-ParedesJM. β-Caryophyllene exerts protective antioxidant effects through the activation of NQO1 in the MPTP model of Parkinson's disease. Neuroscience Letters, 2021, 742. 135534

[125] FriedmanJI, VrijenhoekT, MarkxS, JanssenIM, van der VlietWA, FaasBH, KnoersNV, CahnW, KahnRS, EdelmannL, et al. . CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy. Molecular Psychiatry, 2008, 133261-266.

[126] GaffJ, JackamanC, PapadimitriouJ, WatersS, McLeanC, PriceP. Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease. Experimental and Molecular Pathology, 2021, 120. 104636

[127] GaoJX, LiY, WangSN, ChenXC, LinLL, ZhangH. Overexpression of microRNA-183 promotes apoptosis of substantia nigra neurons via the inhibition of OSMR in a mouse model of Parkinson's disease. International Journal of Molecular Medicine, 2019, 431209-220.

[128] GarcezD, MarquesJ, FernandesM, CoimbraMF, LourençoMC, MachadoD, FreireJ. ATP1A3: An unusual antigen to consider in patients with subacute ataxia and vertical gaze palsy. Multiple Sclerosis and Related Disorders, 2020, 43. 102160

[129] GarcíaS, López-HernándezL, Dávila-MaldonadoL, Cuevas-GarcíaC, Gallegos-ArreolaM, Alcaraz-EstradaS, Cortes-EspinosaL, FloresC, CantoP, VázquezR. Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease. Folia Neuropathologica, 2019, 574335-339.

[130] García-MartínE, Lorenzo-BetancorO, MartínezC, PastorP, Benito-LeónJ, Millán-PascualJ, CallejaP, Díaz-SánchezM, PisaD, Turpín-FenollL, et al. . LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis. BMC Neurology, 2013, 13: 34.

[131] GeczJ, ThomasPQ. Disentangling the paradox of the PCDH19 clustering epilepsy, a disorder of cellular mosaics. Current Opinion in Genetics and Development, 2020, 65: 169-175.

[132] GhareghaniM, ScavoL, JandY, FarhadiN, SadeghiH, GhanbariA, MondelloS, ArnoultD, GharaghaniS, ZibaraK. Melatonin therapy modulates cerebral metabolism and enhances remyelination by increasing PDK4 in a mouse model of multiple sclerosis. Frontiers in Pharmacology, 2019, 10: 147.

[133] GhazaryanH, PetrekM, BoyajyanA. Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene. Psychiatry Research, 2014, 2173158-162.

[134] GiaimeE, SunyachC, DruonC, ScarzelloS, RobertG, GrossoS, AubergerP, GoldbergMS, ShenJ, HeutinkP, et al. . Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death and Differentiation, 2010, 171158-169.

[135] GilbertM, LiZ, WuXN, RohrL, GombosS, HarterK, SchulzeWX. Comparison of path-based centrality measures in protein-protein interaction networks revealed proteins with phenotypic relevance during adaptation to changing nitrogen environments. Journal of Proteomics, 2021, 235. 104114

[136] GoldmanJG, MarrD, ZhouL, OuyangB, LeurgansSE, Berry-KravisE, GoetzCG. Racial differences may influence the role of cholecystokinin polymorphisms in Parkinson's disease hallucinations. Movement Disorders, 2011, 2691781-1782.

[137] GoldsteinO, Gana-WeiszM, ShinerT, AttarR, MordechaiY, WaldmanYY, Bar-ShiraA, ThalerA, GurevichT, MirelmanA, et al. . R869C mutation in molecular motor KIF17 gene is involved in dementia with Lewy bodies. Alzheimers Dement (Amst), 2021, 131. e12143

[138] González-MundoI, Pérez-VielmaNM, Gómez-LópezM, FleuryA, Correa-BasurtoJ, Rosales-HernándezMC, Sixto-LópezY, Martínez-GodinezMLÁ, Domínguez-LópezA, Miliar-GarcíaA. DNA methylation of the RE-1 silencing transcription factor in peripheral blood mononuclear cells and gene expression of antioxidant enzyme in patients with late-onset Alzheimer disease. Experimental Gerontology, 2020, 136. 110951

[139] GorostidiA, Martí-MassóJF, BergarecheA, Rodríguez-OrozMC, LópezdeMunainA, Ruiz-MartínezJ. Genetic mutation analysis of Parkinson's disease patients using multigene next-generation sequencing panels. Molecular Diagnosis and Therapy, 2016, 205481-491.

[140] GotoS, HiranoA. Synaptophysin expression in the striatum in Huntington's disease. Acta Neuropathologica, 1990, 80188-91.

[141] GrewalRP, MorganTE, FinchCE. C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis. Neuroscience Letters, 1999, 271165-67.

[142] GriffioenK, MattsonMP, OkunE. Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington's disease mice. Heliyon, 2018, 41. e00508

[143] GroenK, MaltbyVE, ScottRJ, TajouriL, Lechner-ScottJ. Erythrocyte microRNAs show biomarker potential and implicate multiple sclerosis susceptibility genes. Clinical and Translational Medicine, 2020, 10174-90.

[144] GrossJ, GrimmO, OrtegaG, TeuberI, LeschKP, MeyerJ. Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family. Psychiatric Genetics, 2001, 114197-200.

[145] GruborM, ZivkovicM, SagudM, Nikolac PerkovicM, Mihaljevic-PelesA, PivacN, Muck-SelerD, SvobSD. HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms and extrapyramidal Side effects in haloperidol-treated patients with schizophrenia. International Journal of Molecular Sciences, 2020, 2172345.

[146] GuanF, LinH, ChenG, LiL, ChenT, LiuX, HanJ, LiT. Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function. Science and Reports, 2016, 6: 38048.

[147] GueriniFR, ClericiM, CaglianiR, MalhotraS, MontalbanX, ForniD, AgliardiC, RivaS, CaputoD, GalimbertiD, et al. . No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis. Journal of Neuroimmunology, 2014, 2711–249-52.

[148] Guixa-GonzalezR, BrunoA, Marti-SolanoM, SelentJ. Crosstalk within GPCR heteromers in schizophrenia and Parkinson's disease: Physical or just functional?. Current Medicinal Chemistry, 2012, 1981119-1134.

[149] GuoH, ZhangQ, DaiR, YuB, HoekzemaK, TanJ, TanS, JiaX, ChungWK, HernanR, et al. . NCKAP1 Disruptive variants lead to a neurodevelopmental disorder with core features of autism. American Journal of Human Genetics, 2020, 1075963-976.

[150] HalbgebauerS, NaglM, KlafkiH, HaußmannU, SteinackerP, OecklP, KassubekJ, PinkhardtE, LudolphAC, SoininenH, et al. . Modified serpinA1 as risk marker for Parkinson's disease dementia: Analysis of baseline data. Science and Reports, 2016, 6: 26145.

[151] HallmannK, KudinAP, ZsurkaG, KornblumC, ReimannJ, StüveB, WaltzS, HattingenE, ThieleH, NürnbergP, et al. . Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy. Brain, 2016, 139Pt 2338-345.

[152] HaqueME, AzamS, AktherM, ChoDY, KimIS, ChoiDK. The Neuroprotective effects of GPR4 inhibition through the attenuation of caspase mediated apoptotic cell death in an MPTP induced mouse model of Parkinson's disease. International Journal of Molecular Sciences, 2021, 2294674.

[153] HatstatAK, AhrendtHD, FosterMW, MayneL, MoseleyMA, EnglanderSW, McCaffertyDG. Characterization of small-molecule-induced changes in Parkinson's-related trafficking via the Nedd4 ubiquitin signaling cascade. Cell Chemical Biology, 2021, 28114-25.e9.

[154] HaysSE, GoodwinFK, PaulSM. Cholecystokinin receptors are decreased in basal ganglia and cerebral cortex of Huntington's disease. Brain Research, 1981, 2252452-456.

[155] HeJ, FuJ, FanD. The complement C7 variant rs3792646 is associated with amyotrophic lateral sclerosis in a Han Chinese population. Neurobiology of Aging, 2021, 99: 103.e1-103.e7.

[156] HeckerM, BoxbergerN, IllnerN, FitznerB, SchröderI, WinkelmannA, DudesekA, MeisterS, KoczanD, LorenzP, et al. . A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene. PLoS Genetics, 2019, 152. e1007961

[157] HelbigI, Lopez-HernandezT, ShorO, GalerP, GanesanS, PendziwiatM, RademacherA, EllisCA, HümpferN, SchwarzN, et al. . A recurrent missense variant in AP2M1 impairs clathrin-mediated endocytosis and causes developmental and epileptic encephalopathy. American Journal of Human Genetics, 2019, 10461060-1072.

[158] HelferichAM, BrockmannSJ, ReindersJ, DeshpandeD, HolzmannK, BrennerD, AndersenPM, PetriS, ThalDR, MichaelisJ, et al. . Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS. Cellular and Molecular Life Sciences, 2018, 75234301-4319.

[159] Herrera-RiveroM, SantarelliF, BrosseronF, KummerMP, HenekaMT. Dysregulation of TLR5 and TAM ligands in the Alzheimer's brain as contributors to disease progression. Molecular Neurobiology, 2019, 5696539-6550.

[160] HilgerothA, TellV, KramerS, TotzkeF, SchachteleC. Approaches to a multitargeting drug development: First profiled 3- ethoxycarbonyl-1-aza-9-oxafluorenes representing a perspective compound class targeting Alzheimer disease relevant kinases CDK1, CDK5 and GSK-3β. Medicinal Chemistry, 2014, 10190-97.

[161] HillMJ, KennyE, RocheS, MorrisDW, CorvinA, HawiZ, GillM, AnneyRJ. Allelic expression imbalance of the schizophrenia susceptibility gene CHI3L1: Evidence of cis-acting variation and tissue specific regulation. Psychiatric Genetics, 2011, 216281-286.

[162] HoangN, YuenRKC, HoweJ, DrmicI, AmbrozewiczP, RussellC, VorstmanJ, WeissSK, AnagnostouE, MalowBA, et al. . Sleep phenotype of individuals with autism spectrum disorder bearing mutations in the PER2 circadian rhythm gene. American Journal of Medical Genetics Part A, 2021, 18541120-1130.

[163] HongCT, ChenKY, WangW, ChiuJY, WuD, ChaoTY, HuCJ, ChauKD, BamoduOA. Insulin resistance promotes parkinson's disease through aberrant expression of α-synuclein, mitochondrial dysfunction, and deregulation of the polo-like kinase 2 signaling. Cells, 2020, 93740.

[164] HoogendijkWJ, PurbaJS, HofmanMA, de VosRA, JansenEN, SwaabDF. Depression in Parkinson's disease is not accompanied by more corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus. Biological Psychiatry, 1998, 4312913-917.

[165] HorvathI, IashchishynIA, MoskalenkoRA, WangC, WärmländerSKTS, WallinC, GräslundA, KovacsGG, Morozova-RocheLA. Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson's disease: Ex vivo and in vitro studies. Journal of Neuroinflammation, 2018, 151172.

[166] HuTM, ChenCH, ChuangYA, HsuSH, ChengMC. Resequencing of early growth response 2 (EGR2) gene revealed a recurrent patient-specific mutation in schizophrenia. Psychiatry Research, 2015, 2283958-960.

[167] HubertL, Cannata SerioM, Villoing-GaudéL, BoddaertN, KaminskaA, RioM, LyonnetS, MunnichA, PoirierK, SimonsM, et al. . De novo SCAMP5 mutation causes a neurodevelopmental disorder with autistic features and seizures. Journal of Medical Genetics, 2020, 572138-144.

[168] HurJY. Innate immunity protein IFITM3 in Alzheimer's disease. DNA and Cell Biology, 2021, 40111351-1355.

[169] HurEM, LeeBD. LRRK2 at the crossroad of aging and Parkinson's disease. Genes (Basel), 2021, 124505.

[170] HwangH, SzucsMJ, DingLJ, AllenA, RenX, HaensgenH, GaoF, RhimH, AndradeA, PanJQ, et al. . Neurogranin, encoded by the schizophrenia risk gene NRGN, bidirectionally modulates synaptic plasticity via calmodulin-dependent regulation of the neuronal phosphoproteome. Biological Psychiatry, 2021, 893256-269.

[171] HåkanssonI, TisellA, CasselP, BlennowK, ZetterbergH, LundbergP, DahleC, VrethemM, ErnerudhJ. Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis. Journal of Neuroinflammation, 2018, 151209.

[172] IaccarinoC, MuraME, EspositoS, CartaF, SannaG, TurriniF, CarrìMT, CrosioC. Bcl2-A1 interacts with pro-caspase-3: Implications for amyotrophic lateral sclerosis. Neurobiology of Diseases, 2011, 433642-650.

[173] IatropoulosP, GardellaR, ValsecchiP, MagriC, RattiC, PodaviniD, RossiG, GennarelliM, SacchettiE, BarlatiS, et al. . Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia. Psychiatric Genetics, 2009, 195237-243.

[174] IbarretaD, TaoJ, ParrillaR, AyusoMS. Mutation analysis of chromosome 19 calmodulin (CALM3) gene in Alzheimer's disease patients. Neuroscience Letters, 1997, 2293157-160.

[175] ImaniSZH, HojatiZ, KhalilianS, DehghanianF, KheirollahiM, KhorramiM, ShaygannejadV, MirmosayyebO. Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis. Science and Reports, 2021, 11119260.

[176] IparraguirreL, Muñoz-CullaM, Prada-LuengoI, Castillo-TriviñoT, OlascoagaJ, OtaeguiD. Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. Human Molecular Genetics, 2017, 26183564-3572.

[177] IslamMI, NagakannanP, OgungbolaO, DjordjevicJ, AlbensiBC, EftekharpourE. Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease. Free Radical Biology and Medicine, 2019, 134: 567-580.

[178] IyerM, SubramaniamMD, VenkatesanD, ChoSG, RydingM, MeyerM, VellingiriB. Role of RhoA-ROCK signaling in Parkinson's disease. European Journal of Pharmacology, 2021, 894. 173815

[179] JiW, LiT, PanY, TaoH, JuK, WenZ, FuY, AnZ, ZhaoQ, WangT, et al. . CNTNAP2 is significantly associated with schizophrenia and major depression in the Han Chinese population. Psychiatry Research, 2013, 2073225-228.

[180] JiY, WangD, ZhangB, LuH. Bergenin ameliorates MPTP-induced Parkinson's disease by activating PI3K/Akt signaling pathway. Journal of Alzheimer's Disease, 2019, 723823-833.

[181] JiangC, LiL, WuM, HaoM, FengJ. Association of KCNJ10 variants and the susceptibility to clinical epilepsy. Clinical Neurology and Neurosurgery, 2021, 200. 106340

[182] JiangJ, LongJ, LingW, HuangG, SuL. Genetic variation in the 3'-untranslated region of PAK1 influences schizophrenia susceptibility. Experimental and Therapeutic Medicine, 2017, 1331101-1108.

[183] JinH, GuHY, MaoCJ, ChenJ, LiuCF. Association of inflammatory factors and aging in Parkinson's disease. Neuroscience Letters, 2020, 736. 135259

[184] JoaquimHPG, CostaAC, SerpaMH, TalibLL, GattazWF. Reduced annexin A3 in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 2020, 2704489-494.

[185] JohnsonTP, TyagiR, PatelK, SchiessN, CalabresiPA, NathA. Impaired toll-like receptor 8 signaling in multiple sclerosis. Journal of Neuroinflammation, 2013, 10: 74.

[186] KaiserM, MaletzkiI, HülsmannS, HoltmannB, Schulz-SchaefferW, KirchhoffF, BährM, NeuschC. Progressive loss of a glial potassium channel (KCNJ10) in the spinal cord of the SOD1 (G93A) transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry, 2006, 993900-912.

[187] KajiwaraY, McKenzieA, DorrN, Gama SosaMA, ElderG, SchmeidlerJ, DicksteinDL, BozdagiO, ZhangB, BuxbaumJD. The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits. Human Molecular Genetics, 2016, 25194315-4327.

[188] KalscheuerVM, MusanteL, FangC, HoffmannK, FuchsC, CartaE, DeasE, VenkateswarluK, MenzelC, UllmannR, et al. . A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. Human Mutation, 2009, 30161-68.

[189] KangJQ, MacdonaldRL. Molecular pathogenic basis for GABRG2 mutations associated with a spectrum of epilepsy syndromes, from generalized absence epilepsy to dravet syndrome. JAMA Neurology, 2016, 7381009-1016.

[190] KangJ, RivestS. MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis. Journal of Cell Biology, 2007, 17961219-1230.

[191] KantojärviK, KotalaI, RehnströmK, Ylisaukko-OjaT, VanhalaR, von WendtTN, von WendtL, JärveläI. Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD). Autism Research, 2011, 43228-233.

[192] KawashimaK, KishiT, IkedaM, KitajimaT, YamanouchiY, KinoshitaY, TakahashiN, SaitoS, OhiK, YasudaY, et al. . No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 2008, 147B71327-1331.

[193] KeaneyJ, GasserJ, GilletG, ScholzD, KadiuI. Inhibition of Bruton's tyrosine kinase modulates microglial phagocytosis: therapeutic implications for Alzheimer's disease. Journal of Neuroimmune Pharmacology, 2019, 143448-461.

[194] KeshariPK, HarboHF, MyhrKM, AarsethJH, BosSD, BergeT. Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood. BMC Genetics, 2016, 17: 59.

[195] KhalilianS, HojatiZ, DehghanianF, ShaygannejadV, ImaniSZH, KheirollahiM, KhorramiM, MirmosayyebO. Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population. Science and Reports, 2021, 1117713.

[196] KiaeiM, KipianiK, PetriS, ChoiDK, ChenJ, CalingasanNY, BealMF. Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry, 2005, 932403-411.

[197] KimY, KongM, LeeC. Association of intronic sequence variant in the gene encoding spleen tyrosine kinase with susceptibility to vascular dementia. World Journal of Biological Psychiatry, 2013, 143220-226.

[198] KimK, WiS, SeoJH, PyoS, ChoSR. Reduced interaction of aggregated α-synuclein and VAMP2 by environmental enrichment alleviates hyperactivity and anxiety in a model of Parkinson's disease. Genes (Basel), 2021, 123392.

[199] KimuraH, FujitaY, KawabataT, IshizukaK, WangC, IwayamaY, OkahisaY, KushimaI, MorikawaM, UnoY, et al. . A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility. Translational Psychiatry, 2017, 78. e1214

[200] KirchnerA, BaglaS, DachetF, LoebJA. DUSP4 appears to be a highly localized endogenous inhibitor of epileptic signaling in human neocortex. Neurobiology of Diseases, 2020, 145. 105073

[201] KishiT, IkedaM, KitajimaT, YamanouchiY, KinoshitaY, KawashimaK, OkochiT, InadaT, OzakiN, IwataN. Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population. Journal of Neural Transmission (Vienna), 2008, 115101457-1461.

[202] KoWK, Martin-NegrierML, BezardE, CrossmanAR, RavenscroftP. RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease. Neurobiology of Diseases, 2014, 70: 138-148.

[203] KogaM, IshiguroH, HoriuchiY, InadaT, UjikeH, ItokawaM, OtowaT, WatanabeY, SomeyaT, ArinamiT. Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia. Psychiatric Genetics, 2010, 203123-125.

[204] KongY, ZhangS, HuangL, ZhangC, XieF, ZhangZ, HuangQ, JiangD, LiJ, ZhouW, et al. . Positron emission computed tomography imaging of synaptic vesicle glycoprotein 2A in Alzheimer's disease. Frontiers in Aging Neuroscience, 2021, 13. 731114

[205] KonyukhM, DelormeR, ChasteP, LeblondC, LemièreN, NygrenG, AnckarsäterH, RastamM, StåhlbergO, AmsellemF, et al. . Variations of the candidate SEZ6L2 gene on chromosome 16p11.2 in patients with autism spectrum disorders and in human populations. PLoS ONE, 2011, 63e17289.

[206] KoobAO, ShakedGM, BenderA, BisquerttA, RockensteinE, MasliahE. Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease. Brain Research, 2014, 1591: 102-110.

[207] KoppelJ, CampagneF, VingtdeuxV, Dreses-WerringloerU, EwersM, RujescuD, HampelH, GordonML, ChristenE, ChapuisJ, et al. . CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease. Molecular Medicine, 2011, 179–10974-979.

[208] KumarRA, SudiJ, BabatzTD, BruneCW, OswaldD, YenM, NowakNJ, CookEH, ChristianSL, DobynsWB. A de novo 1p34.2 microdeletion identifies the synaptic vesicle gene RIMS3 as a novel candidate for autism. Journal of Medical Genetics, 2010, 47281-90.

[209] KumariR, KumarR, KumarS, SinghAK, HanpudeP, JangirD, MaitiTK. Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease. Journal of Biological Chemistry, 2020, 295113466-3484.

[210] KuritaH, YabeS, UedaT, IndenM, KakitaA, HozumiI. MicroRNA-5572 is a novel MicroRNA-regulating SLC30A3 in sporadic amyotrophic lateral sclerosis. International Journal of Molecular Sciences, 2020, 21124482.

[211] KurzawskiM, BiałeckaM, SławekJ, Kłodowska-DudaG, DroździkM. Association study of GATA-2 transcription factor gene (GATA2) polymorphism and Parkinson's disease. Parkinsonism and Related Disorders, 2010, 164284-287.

[212] KwonJ, SuessmilchM, McCollA, CavanaghJ, MorrisBJ. Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: Implications for schizophrenia risk. Science and Reports, 2021, 11123841.

[213] KümpfelT, Then BerghF, FriessE, UhrM, YassouridisA, TrenkwalderC, HolsboerF. Dehydroepiandrosterone response to the adrenocorticotropin test and the combined dexamethasone and corticotropin-releasing hormone test in patients with multiple sclerosis. Neuroendocrinology, 1999, 706431-438.

[214] KüçükaliCI, SalmanB, YüceerH, UlusoyC, AbacıN, EkmekciSS, TüzünE, BilgiçB, HanağasıHA. Small ubiquitin-related modifier (SUMO) 3 and SUMO4 gene polymorphisms in Parkinson's disease. Neurological Research, 2020, 426451-457.

[215] LahdelmaL, JeeKJ, JoffeG, TchoukhineE, OksanenJ, KaurS, KnuutilaS, AnderssonLC. Altered expression of myeloperoxidase precursor, myeloid cell nuclear differentiation antigen, Fms-related tyrosine kinase 3 ligand, and antigen CD11A genes in leukocytes of clozapine-treated schizophrenic patients. Journal of Clinical Psychopharmacology, 2006, 263335-338.

[216] LajinB, AlachkarA, MichatiR, AlhajSA. Association between polymorphisms in the genes for tumor suppressor protein p53 and its regulator NAD(P)H: Quinone oxidoreductase 1 (NQO1) and schizophrenia in a Syrian study cohort. Archives of Medical Research, 2013, 442121-126.

[217] LanannaBV, McKeeCA, KingMW, Del-AguilaJL, DimitryJM, FariasFHG, NadarajahCJ, XiongDD, GuoC, CammackAJ, et al. . Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis. Science Translational Medicine, 2020, 12574eaax3519.

[218] LangC, CampbellKR, RyanBJ, CarlingP, AttarM, VowlesJ, PerestenkoOV, BowdenR, BaigF, KastenM, et al. . Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes. Cell Stem Cell, 2019, 24193-106.e6.

[219] LangY, LiY, YuH, LinL, ChenX, WangS, ZhangH. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 via miR-221-3p binding. Aging (Albany NY), 2020, 1297660-7678.

[220] LarkinPB, MuchowskiPJ. Genetic deficiency of complement component 3 does not alter disease progression in a mouse model of Huntington's disease. Journal of Huntington's Disease, 2012, 11107-118.

[221] LarrickJW, MendelsohnAR. Modulation of cGAS-STING pathway by nicotinamide riboside in Alzheimer's disease. Rejuvenation Research, 2021, 245397-402.

[222] LashgariNA, RoudsariNM, MomtazS, SathyapalanT, AbdolghaffariAH, SahebkarA. The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease. Journal of Neuroimmunology, 2021, 361. 577758

[223] LashkariK, TeagueG, ChenH, LinYQ, KumarS, McLaughlinMM, LópezFJ. A monoclonal antibody targeting amyloid β (Aβ) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer's disease. PLoS ONE, 2018, 135. e0195751

[224] LeeJY, HanSH, ParkMH, BaekB, SongIS, ChoiMK, TakuwaY, RyuH, KimSH, HeX, et al. . Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's disease. Nature Communications, 2018, 911479.

[225] LeeJ, HwangYJ, ShinJY, LeeWC, WieJ, KimKY, LeeMY, HwangD, RatanRR, PaeAN, et al. . Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease. Acta Neuropathologica, 2013, 1255727-739.

[226] LeeJS, LeeY, AndréEA, LeeKJ, NguyenT, FengY, JiaN, HarrisBT, BurnsMP, PakDTS. Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice. PLoS ONE, 2019, 147. e0219691

[227] LehmannSM, RosenbergerK, KrügerC, HabbelP, DerkowK, KaulD, RybakA, BrandtC, SchottE, WulczynFG, et al. . Extracellularly delivered single-stranded viral RNA causes neurodegeneration dependent on TLR7. The Journal of Immunology, 2012, 18931448-1458.

[228] LeiL, ShenXM, WangSY, LuY, WangSB, ChenH, LiuZ, OuyangYS, DuoJY, DaYW, et al. . Presence of antibodies against low-density lipoprotein receptor-related protein 4 and impairment of neuromuscular junction in a Chinese cohort of amyotrophic lateral sclerosis. Chinese Medical Journal (England), 2019, 132121487-1489.

[229] LemereCA, MungerJS, ShiGP, NatkinL, HaassC, ChapmanHA, SelkoeDJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. American Journal of Pathology, 1995, 1464848-860

[230] LeriM, ChaudharyH, IashchishynIA, PansieriJ, SvedružićŽM, Gómez AlcaldeS, MusteikyteG, SmirnovasV, StefaniM, BucciantiniM, et al. . Natural compound from olive oil inhibits S100A9 amyloid formation and cytotoxicity: implications for preventing Alzheimer's disease. ACS Chemical Neuroscience, 2021, 12111905-1918.

[231] LiJ, ChenL, QinQ, WangD, ZhaoJ, GaoH, YuanX, ZhangJ, ZouY, MaoZ, et al. . Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. Neurobiology of Diseases, 2022, 163. 105605

[232] LiP, EnsinkE, LangS, MarshallL, SchilthuisM, LampJ, VegaI, LabrieV. Hemispheric asymmetry in the human brain and in Parkinson's disease is linked to divergent epigenetic patterns in neurons. Genome Biology, 2020, 21161.

[233] LiY, LiW, TanY, LiuF, CaoY, LeeKY. Hierarchical decomposition for betweenness centrality measure of complex networks. Science and Reports, 2017, 7: 46491.

[234] LiG, LiM, WangJ, LiY, PanY. United neighborhood closeness centrality and orthology for predicting essential proteins. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2020, 1741451-1458.

[235] LiH, LiuZ, WuY, ChenY, WangJ, WangZ, HuangD, WangM, YuM, FeiJ, et al. . The deficiency of NRSF/REST enhances the pro-inflammatory function of astrocytes in a model of Parkinson's disease. Biochimica Et Biophysica Acta, Molecular Basis of Disease, 2020, 18661. 165590

[236] LiQ, ZhangP, CaiY. Genkwanin suppresses MPP+-induced cytotoxicity by inhibiting TLR4/MyD88/NLRP3 inflammasome pathway in a cellular model of Parkinson's disease. Neurotoxicology, 2021, 87: 62-69.

[237] LiH, ZhangQ, LiN, WangF, XiangH, ZhangZ, SuY, HuangY, ZhangS, ZhaoG, et al. . Plasma levels of Th17-related cytokines and complement C3 correlated with aggressive behavior in patients with schizophrenia. Psychiatry Research, 2016, 246: 700-706.

[238] LiT, ZhuJ. Entanglement of CCR5 and Alzheimer's disease. Frontiers in Aging Neuroscience, 2019, 11: 209.

[239] LibigerO, ShawLM, WatsonMH, NairnAC, UmañaKL, BiarnesMC, Canet-AvilésRM, JackCRJr, BretonYA, CortesL, et al. . Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease. Alzheimer's and Dementia, 2021, 17121976-1987.

[240] LieblMP, KayaAM, TenzerS, MittenzweiR, Koziollek-DrechslerI, SchildH, MoosmannB, BehlC, ClementAM. Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis. Free Radical Biology and Medicine, 2014, 72: 41-54.

[241] LimJL, NgEY, LimSY, TanAH, Abdul-AzizZ, IbrahimKA, GopalaiAA, TayYW, VijayanathanY, TohTS, et al. . Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry. Neurological Sciences, 2021, 42104203-4207.

[242] LinYS, LinFY, HsiaoYH. Myostatin is associated with cognitive decline in an animal model of Alzheimer's disease. Molecular Neurobiology, 2019, 5631984-1991.

[243] LinF, LinW, ZhuC, LinJ, ZhuJ, LiXY, WangZ, WangC, HuangH. Sequencing of neurofilament genes identified NEFH Ser787Arg as a novel risk variant of sporadic amyotrophic lateral sclerosis in Chinese subjects. BMC Medical Genomics, 2021, 141222.

[244] LiuQ, Bautista-GomezJ, HigginsDA, YuJ, XiongY. Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration. Science Signaling, 2021, 14693eabg3555.

[245] LiuY, HaoW, DawsonA, LiuS, FassbenderK. Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. Journal of Biological Chemistry, 2009, 28463691-3699.

[246] LiuC, HongK, ChenH, NiuY, DuanW, LiuY, JiY, DengB, LiY, LiZ, et al. . Evidence for a protective role of the CX3CL1/CX3CR1 axis in a model of amyotrophic lateral sclerosis. Biological Chemistry, 2019, 4005651-661.

[247] LiuSJ, YangC, ZhangY, SuRY, ChenJL, JiaoMM, ChenHF, ZhengN, LuoS, et al. . Neuroprotective effect of β-asarone against Alzheimer's disease: Regulation of synaptic plasticity by increased expression of SYP and GluR1. Drug Design, Development and Therapy, 2016, 10: 1461-1469.

[248] LiuFF, ZhangZ, ChenW, GuHY, YanQJ. Regulatory mechanism of microRNA-377 on CDH13 expression in the cell model of Alzheimer's disease. European Review for Medical and Pharmacological Sciences, 2018, 2292801-2808.

[249] LiuK, ZhangW, LiY, DingQ, BaiY, WangF, XuG. Human peripheral blood-derived mesenchymal stem cells with NTRK1 over-expression enhance repairing capability in a rat model of Parkinson's disease. Cytotechnology, 2018, 7051291-1299.

[250] LohoffFW, BlochPJ, WellerAE, FerraroTN, BerrettiniWH. Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder. Psychiatric Genetics, 2008, 18253-58.

[251] LotankarS, PrabhavalkarKS, BhattLK. Biomarkers for Parkinson's disease: Recent advancement. Neuroscience Bulletin, 2017, 335585-597.

[252] LouF, LiM, LiuN, LiX, RenY, LuoX. The polymorphism of SREBF1 gene rs11868035 G/A is associated with susceptibility to Parkinson's disease in a Chinese population. International Journal of Neuroscience, 2019, 1297660-665.

[253] LoveMI, HuberW, AndersS. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 2014, 1512550.

[254] LuG, LiuW, HuangX, ZhaoY. Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease. Arquivos De Neuro-Psiquiatria, 2020, 78276-80.

[255] LuoX, GuoL, DaiXJ, WangQ, ZhuW, MiaoX, GongH. Abnormal intrinsic functional hubs in alcohol dependence: Evidence from a voxelwise degree centrality analysis. Neuropsychiatric Disease and Treatment, 2017, 13: 2011-2020.

[256] LvRJ, HeJS, FuYH, ShaoXQ, WuLW, LuQ, JinLR, LiuH. A polymorphism in CALHM1 is associated with temporal lobe epilepsy. Epilepsy and Behavior, 2011, 204681-685.

[257] LöfflerS, KlimkeA, KronenwettR, KobbeG, HaasR, FehselK. Clozapine mobilizes CD34+ hematopoietic stem and progenitor cells and increases plasma concentration of interleukin 6 in patients with schizophrenia. Journal of Clinical Psychopharmacology, 2010, 305591-595.

[258] MacNairL, XiaoS, MileticD, GhaniM, JulienJP, KeithJ, ZinmanL, RogaevaE, RobertsonJ. MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis. Brain, 2016, 139Pt 186-100.

[259] MalekNM, GrossetKA, StewartD, MacpheeGJ, GrossetDG. Prescription of drugs with potential adverse effects on cardiac conduction in Parkinson's disease. Parkinsonism and Related Disorders, 2013, 196586-589.

[260] ManevH, ManevR. 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease. Medical Hypotheses, 2006, 663501-503.

[261] ManochaGD, GhatakA, PuigKL, KranerSD, NorrisCM, CombsCK. NFATc2 modulates microglial activation in the AβPP/PS1 mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 2017, 583775-787.

[262] MartinPM, YangX, RobinN, LamE, RabinowitzJS, ErdmanCA, QuinnJ, WeissLA, HamiltonSP, et al. . A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation. Translational Psychiatry, 2013, 39. e301

[263] MatosinN, Fernandez-EnrightF, FungSJ, LumJS, EngelM, AndrewsJL, HuangXF, WeickertCS, NewellKA. Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: Towards a model of mGluR5 dysregulation. Acta Neuropathologica, 2015, 1301119-129.

[264] MernerND, ChandlerMR, BourassaC, LiangB, KhannaAR, DionP, RouleauGA, KahleKT. Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Frontiers in Cellular Neuroscience, 2015, 9: 386.

[265] MeyerMA. Neuronal localization of GAS7 within human brain tissue: Implications for schizophrenia research. Neurology International, 2018, 1047563.

[266] MilaniM, MammarellaE, RossiS, MieleC, LattanteS, SabatelliM, CozzolinoM, D'AmbrosiN, ApolloniS. Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 2021, 181132.

[267] MironJ, PicardC, LabontéA, AuldD, BreitnerJ, PoirierJ. Association of PPP2R1A with Alzheimer's disease and specific cognitive domains. Neurobiology of Aging, 2019, 81: 234-243.

[268] MiyaokaT, SenoH, IshinoH. Increased expression of Wnt-1 in schizophrenic brains. Schizophrenia Research, 1999, 3811-6.

[269] ModyN, AgouniA, McIlroyGD, PlattB, DelibegovicM. Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein. Diabetologia, 2011, 5482143-2151.

[270] MoghadamS, ErfanmaneshM, EsmaeilzadehA. Interleukin 35 and hepatocyte growth factor; as a novel combined immune gene therapy for multiple sclerosis disease. Medical Hypotheses, 2017, 109: 102-105.

[271] MogiM, HaradaM, KondoT, RiedererP, NagatsuT. Brain beta 2-microglobulin levels are elevated in the striatum in Parkinson's disease. Journal of Neural Transmission. Parkinson's Disease and Dementia Section, 1995, 9187-92.

[272] MolMO, WongTH, MelhemS, BasuS, ViscusiR, GaljartN, RozemullerAJM, FalliniC, LandersJE, KaatLD, et al. . Novel TUBA4A variant associated with familial frontotemporal dementia. Neurology Genetics, 2021, 73. e596

[273] MoloneyEB, MoskitesA, FerrariEJ, IsacsonO, HallettPJ. The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress. Neurobiology of Diseases, 2018, 120: 1-11.

[274] MüllerN, SchwarzMJ. COX-2 inhibition in schizophrenia and major depression. Current Pharmaceutical Design, 2008, 14141452-1465.

[275] NakamuraK, IwataY, AnithaA, MiyachiT, ToyotaT, YamadaS, TsujiiM, TsuchiyaKJ, IwayamaY, YamadaK, et al. . Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011, 352454-458.

[276] Nemutlu SamurD, AkçayG, YıldırımS, ÖzkanA, ÇekerT, DerinN, TanrıöverG, AslanM, AğarA, ÖzbeyG. Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation. Neuropharmacology, 2022, 208. 108977

[277] NikhilK, ViccaroK, ShahK. Multifaceted regulation of ALDH1A1 by Cdk5 in Alzheimer's disease pathogenesis. Molecular Neurobiology, 2019, 5621366-1390.

[278] NodaY, ShimazawaM, TanakaH, TamuraS, InoueT, TsurumaK, HaraH. VGF and striatal cell damage in in vitro and in vivo models of Huntington's disease. Pharmacology Research and Perspectives, 2015, 33. e00140

[279] NodaY, TanakaM, NakamuraS, ItoJ, KakitaA, HaraH, ShimazawaM. Identification of VGF nerve growth factor inducible-producing cells in human spinal cords and expression change in patients with amyotrophic lateral sclerosis. International Journal of Medical Sciences, 2020, 174480-489.

[280] Noori-DaloiiMR, KheirollahiM, MahbodP, MohammadiF, AstanehAN, ZarindastMR, AzimiC, MohammadiMR. Alpha- and beta-synucleins mRNA expression in lymphocytes of schizophrenia patients. Genetic Testing and Molecular Biomarkers, 2010, 145725-729.

[281] NorrisPJ, WaldvogelHJ, FaullRL, LoveDR, EmsonPC. Decreased neuronal nitric oxide synthase messenger RNA and somatostatin messenger RNA in the striatum of Huntington's disease. Neuroscience, 1996, 7241037-1047.

[282] NumataS, UenoS, IgaJ, YamauchiK, HongweiS, HashimotoR, TakedaM, KunugiH, ItakuraM, OhmoriT. TGFBR2 gene expression and genetic association with schizophrenia. Journal of Psychiatric Research, 2008, 426425-432.

[283] NursalAF, AydinPC, PehlivanM, SeverU, PehlivanS. UCP2 and CFH gene variants with genetic susceptibility to schizophrenia in Turkish population. Endocrine, Metabolic and Immune Disorders: Drug Targets, 2021, 21112084-2089.

[284] ObergasteigerJ, FrapportiG, PramstallerPP, HicksAA, VoltaM. A new hypothesis for Parkinson's disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics. Molecular Neurodegeneration, 2018, 13140.

[285] OecklP, WeydtP, ThalDR, WeishauptJH, LudolphAC, OttoM. Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis. Acta Neuropathologica, 2020, 1391119-134.

[286] OliveiraJ, HamdaniN, EtainB, BennabiM, BoukouaciW, AmokraneK, FortierC, MarzaisF, BengoufaD, BellivierF, et al. . Genetic association between a 'standing' variant of NOD2 and bipolar disorder. Immunobiology, 2014, 21910766-771.

[287] OliveiraJ, KazmaR, Le FlochE, BennabiM, HamdaniN, BengoufaD, DahounM, ManierC, BellivierF, KrishnamoorthyR, et al. . Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: A gene-environment interaction study. International Journal of Bipolar Disorders, 2016, 4111.

[288] OnwordiEC, WhitehurstT, MansurA, StattonB, BerryA, QuinlanM, O'ReganDP, RogdakiM, MarquesTR, RabinerEA, et al. . The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: A multimodal PET and magnetic resonance spectroscopy brain imaging study. Translational Psychiatry, 2021, 111393.

[289] OrabonaGM, Griesi-OliveiraK, VadaszE, BulcãoVL, TakahashiVN, MoreiraES, Furia-SilvaM, Ros-MeloAM, DouradoF, MatioliSR, et al. . HTR1B and HTR2C in autism spectrum disorders in Brazilian families. Brain Research, 2009, 1250: 14-19.

[290] Orozco-DíazR, Sánchez-ÁlvarezA, Hernández-HernándezJM, Tapia-RamírezJ. The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington's disease. PLoS ONE, 2019, 147. e0220393

[291] PalaszE, WysockaA, GasiorowskaA, ChalimoniukM, NiewiadomskiW, NiewiadomskaG. BDNF as a Promising therapeutic agent in Parkinson's disease. International Journal of Molecular Sciences, 2020, 2131170.

[292] PantS, WeinerR, MartonMJ. Navigating the rapids: The development of regulated next-generation sequencing-based clinical trial assays and companion diagnostics. Frontiers in Oncology, 2014, 4: 78.

[293] ParacchiniL, BeltrameL, BoeriL, FuscoF, CaffarraP, MarchiniS, AlbaniD, ForloniG. Exome sequencing in an Italian family with Alzheimer's disease points to a role for seizure-related gene 6 (SEZ6) rare variant R615H. Alzheimer's Research and Therapy, 2018, 101106.

[294] PatelN, CriderA, PandyaCD, AhmedAO, PillaiA. Altered mRNA levels of glucocorticoid receptor, mineralocorticoid receptor, and co-chaperones (FKBP5 and PTGES3) in the middle frontal gyrus of autism spectrum disorder subjects. Molecular Neurobiology, 2016, 5342090-2099.

[295] PedersenWA, McCullersD, CulmseeC, HaugheyNJ, HermanJP, MattsonMP. Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease. Neurobiology of Diseases, 2001, 83492-503.

[296] Perez-BecerrilC, MorrisAG, MortimerA, McKennaPJ, de BellerocheJ. Common variants in the chromosome 2p23 region containing the SLC30A3 (ZnT3) gene are associated with schizophrenia in female but not male individuals in a large collection of European samples. Psychiatry Research, 2016, 246: 335-340.

[297] PeriñánMT, Macías-GarcíaD, Labrador-EspinosaMÁ, JesúsS, Buiza-RuedaD, Adarmes-GómezAD, Muñoz-DelgadoL, Gómez-GarreP, MirP. Association of PICALM with cognitive impairment in Parkinson's disease. Movement Disorders, 2021, 361118-123.

[298] PiazzaF, GalimbertiG, ContiE, IsellaV, PerlangeliMV, SperanzaT, BorroniB, PoglianiEM, PadovaniA, FerrareseC. Increased tissue factor pathway inhibitor and homocysteine in Alzheimer's disease. Neurobiology of Aging, 2012, 332226-233.

[299] PichitpunpongC, ThongkornS, KanlayaprasitS, YuwattanaW, PlaingamW, SangsuthumS, AizatWM, BaharumSN, TencomnaoT, HuVW, et al. . Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment. PLoS ONE, 2019, 143. e0214198

[300] PicóS, ParrasA, Santos-GalindoM, Pose-UtrillaJ, CastroM, FragaE, HernándezIH, ElorzaA, AntaH, WangN, et al. . CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease. Science Translational Medicine, 2021, 136137104.

[301] PinachoR, VillalmanzoN, MeanaJJ, FerrerI, BerenguerasA, HaroJM, VillénJ, RamosB. Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia. Schizophrenia Research, 2016, 1771–388-97.

[302] PirasIS, KrateJ, DelvauxE, NolzJ, De BothMD, MastroeniDF, SerranoGE, SueLI, BeachTG, ColemanPD, et al. . Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus. Brain Research, 2019, 1719: 217-224.

[303] PlagmanA, HoscheidtS, McLimansKE, KlinedinstB, PappasC, AnantharamV, KanthasamyA, WilletteAA. Cholecystokinin and Alzheimer's disease: A biomarker of metabolic function, neural integrity, and cognitive performance. Neurobiology of Aging, 2019, 76: 201-207.

[304] PonsV, LévesqueP, PlanteMM, RivestS. Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease. Alzheimer's Research and Therapy, 2021, 1318.

[305] PopovaSN, AlafuzoffI. Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration. Journal of Alzheimer's Disease, 2013, 373603-610.

[306] PrakashA, KumarV, BanerjeeA, LynnAM, PrasadR. Structural heterogeneity in RNA recognition motif 2 (RRM2) of TAR DNA-binding protein 43 (TDP-43): Clue to amyotrophic lateral sclerosis. Journal of Biomolecular Structure and Dynamics, 2021, 391357-367.

[307] RangasamySB, JanaM, RoyA, CorbettGT, KunduM, ChandraS, MondalS, DasarathiS, MufsonEJ, MishraRK, et al. . Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology. The Journal of Clinical Investigation, 2018, 128104297-4312.

[308] RasmussenKL, NordestgaardBG, Frikke-SchmidtR, NielsenSF. An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer's disease-A cohort study of 95,442 individuals. Alzheimer's and Dementia, 2018, 14121589-1601.

[309] RasmussenHB, TimmS, WangAG, SøebyK, LublinH, FengerM, HemmingsenR, WergeT. Association between the CCR5 32-bp deletion allele and late onset of schizophrenia. American Journal of Psychiatry, 2006, 1633507-511.

[310] Ratta-AphaW, MouriK, BokuS, IshiguroH, OkazakiS, OtsukaI, SoraI, ArinamiT, ShirakawaO, HishimotoA. A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia. Psychiatry Research, 2015, 2302424-429.

[311] ReimandJ, KullM, PetersonH, HansenJ, ViloJ. g:Profiler–a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Research, 2007, 35Web server issueW193-W200.

[312] RobertsE. GABAergic malfunction in the limbic system resulting from an aboriginal genetic defect in voltage-gated Na+-channel SCN5A is proposed to give rise to susceptibility to schizophrenia. Advances in Pharmacology, 2006, 54: 119-145.

[313] RobinX, TurckN, HainardA, TibertiN, LisacekF, SanchezJC, MüllerM. pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics, 2011, 12: 77.

[314] RudinskiyN, KanekoYA, BeesenAA, GokceO, RégulierE, DéglonN, Luthi-CarterR. Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons. Journal of Neurochemistry, 2009, 1112460-472.

[315] RussoAJ. Increased epidermal growth factor receptor (EGFR) associated with hepatocyte growth factor (HGF) and symptom severity in children with autism spectrum disorders (ASDs). J Cent Nerv Syst Dis., 2014, 6: 79-83.

[316] RussoP, KisialiouA, MoroniR, PrinziG, FiniM. Effect of genetic polymorphisms (SNPs) in CHRNA7 gene on response to acetylcholinesterase inhibitors (AChEI) in patients with Alzheimer's DISEASE. Current Drug Targets, 2017, 18101179-1190.

[317] RyoA, TogoT, NakaiT, HiraiA, NishiM, YamaguchiA, SuzukiK, HirayasuY, KobayashiH, PerremK, et al. . Prolyl-isomerase Pin1 accumulates in lewy bodies of Parkinson disease and facilitates formation of alpha-synuclein inclusions. Journal of Biological Chemistry, 2006, 28174117-4125.

[318] SalehiZ, RajaeiF. Expression of hepatocyte growth factor in the serum and cerebrospinal fluid of patients with Parkinson's disease. Journal of Clinical Neuroscience, 2010, 17121553-1556.

[319] SanfilippoC, MusumeciG, KazakovaM, MazzoneV, CastrogiovanniP, ImbesiR, Di RosaM. GNG13 Is a potential marker of the state of health of Alzheimer's disease patients' cerebellum. Journal of Molecular Neuroscience, 2021, 7151046-1060.

[320] SantosR, LinkerSB, SternS, MendesAPD, ShokhirevMN, EriksonG, Randolph-MooreL, RachaV, KimY, KelsoeJR, et al. . Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. Molecular Psychiatry, 2021, 2662440-2456.

[321] SassoneJ, RealeC, DatiG, RegoniM, PellecchiaMT, GaravagliaB. The role of VPS35 in the pathobiology of Parkinson's disease. Cellular and Molecular Neurobiology, 2021, 412199-227.

[322] SatohJ, YamamotoY, AsahinaN, KitanoS, KinoY. RNA-Seq data mining: Downregulation of NeuroD6 serves as a possible biomarker for Alzheimer's disease brains. Disease Markers, 2014, 2014. 123165

[323] SayadA, RanjbaranF, Ghafouri-FardS, Arsang-JangS, TaheriM. Expression analysis of CYFIP1 and CAMKK2 genes in the blood of epileptic and schizophrenic patients. Journal of Molecular Neuroscience, 2018, 653336-342.

[324] ScalaM, Zonneveld-HuijssoonE, BrienzaM, MecarelliO, van der HoutAH, ZambrelliE, TurnerK, ZaraF, PeronA, VignoliA, et al. . De novo ARHGEF9 missense variants associated with neurodevelopmental disorder in females: Expanding the genotypic and phenotypic spectrum of ARHGEF9 disease in females. Neurogenetics, 2021, 22187-94.

[325] ScarrE, UdawelaM, GreenoughMA, NeoJ, Suk SeoM, MoneyTT, UpadhyayA, BushAI, EverallIP, ThomasEA, et al. . Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia. NPJ Schizophrenia, 2016, 2: 16002.

[326] SchuhmacherA, MössnerR, QuednowBB, KühnKU, WagnerM, CvetanovskaG, RujescuD, ZillP, MöllerHJ, RietschelM, et al. . Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. Pharmacogenetics and Genomics, 2009, 1911843-851.

[327] SchweigJE, YaoH, Beaulieu-AbdelahadD, Ait-GhezalaG, MouzonB, CrawfordF, MullanM, ParisD. Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. Acta Neuropathologica Communications, 2017, 5169.

[328] SeoMH, LimS, YeoS. Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model. BMC Neuroscience, 2021, 22165.

[329] SerajeeFJ, NabiR, ZhongH, Mahbubul HuqAH. Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: Implications for phosphatidylinositol signalling in autism. Journal of Medical Genetics, 2003, 4011. e119

[330] SferraA, FattoriF, RizzaT, FlexE, BellacchioE, BrusellesA, PetriniS, CecchettiS, TesonM, RestaldiF, et al. . Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy. Human Molecular Genetics, 2018, 27111892-1904.

[331] ShannonP, MarkielA, OzierO, BaligaNS, WangJT, RamageD, AminN, SchwikowskiB. Ideker T Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research, 2003, 13112498-2504.

[332] ShaoK, ShanS, RuW, MaC. Association between serum NPTX2 and cognitive function in patients with vascular dementia. Brain and Behavior: A Cognitive Neuroscience Perspective, 2020, 1010. e01779

[333] SharmaM, RajendraraoS, ShahaniN, Ramírez-JarquínUN, SubramaniamS. Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America, 2020, 1172715989-15999.

[334] ShenQ, ZhangJ, WangY, LiuB, LiX, ZhaoQ, ChenS, JiJ, YangF, WanC, et al. . No association between the KCNH1, KCNJ10 and KCNN3 genes and schizophrenia in the Han Chinese population. Neuroscience Letters, 2011, 487161-65.

[335] ShepardR, HeslinK, HagerdornP, CoutellierL. Downregulation of Npas4 in parvalbumin interneurons and cognitive deficits after neonatal NMDA receptor blockade: Relevance for schizophrenia. Translational Psychiatry, 2019, 9199.

[336] ShinS, SantiA, HuangS. Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes. Molecular Brain, 2021, 14124.

[337] ShiraishiM, KobayashiT, WatanabeH, KamoT, HasegawaY. Serum somatostatin in early-stage Parkinson's disease. Acta Neurologica Scandinavica, 2010, 1214225-229.

[338] ShirtsBH, KimJJ, ReichS, DickersonFB, YolkenRH, DevlinB, NimgaonkarVL. Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. Schizophrenia Research, 2007, 941–3342-353.

[339] SinghAS, ChandraR, GuhathakurtaS, SinhaS, ChatterjeeA, AhmedS, GhoshS, RajammaU. Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2013, 45: 131-143.

[340] SolarskiM, WangH, WilleH, Schmitt-UlmsG. Somatostatin in Alzheimer's disease: A new role for an old player. Prion, 2018, 1211-8.

[341] SriwimolW, LimprasertP. Significant changes in plasma alpha-Synuclein and beta-Synuclein levels in male children with autism spectrum disorder. BioMed Research International, 2018, 2018: 4503871.

[342] SrourM, ShimokawaN, HamdanFF, NassifC, PoulinC, Al GazaliL, RosenfeldJA, KoibuchiN, RouleauGA, Al ShamsiA, et al. . Dysfunction of the cerebral glucose transporter SLC45A1 in individuals with intellectual disability and epilepsy. American Journal of Human Genetics, 2017, 1005824-830.

[343] StaatsKA, SchönefeldtS, Van RillaerM, Van HoeckeA, Van DammeP, RobberechtW, ListonA, Van Den BoschL. Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience, 2013, 7: 249.

[344] StambergerH, NikanorovaM, WillemsenMH, AccorsiP, AngrimanM, BaierH, Benkel-HerrenbrueckI, BenoitV, BudettaM, CaliebeA, et al. . STXBP1 encephalopathy: A neurodevelopmental disorder including epilepsy. Neurology, 2016, 8610954-962.

[345] StromSP, StoneJL, Ten BoschJR, MerrimanB, CantorRM, GeschwindDH, NelsonSF. High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene. Molecular Psychiatry, 2010, 1510996-1005.

[346] SubbarayanMS, Joly-AmadoA, BickfordPC, NashKR. CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. Pharmacology and Therapeutics, 2021.

[347] SubramanianN, RamanathanS, PaulSFD, VenkatesanV, KoshyT. A case-control association of RANTES (-28C >G) and CCR5-Delta32 polymorphisms with Parkinson's disease in Indians. Neuroscience Letters, 2020, 739. 135404

[348] SunX, WangQ, BlennowK, ZetterbergH, McCarthyM, LoewensteinDA, VontellR, YueZ, ZhangB. Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex. Alzheimers Dement (NY), 2021, 71. e12162

[349] SupriyantoI, WatanabeY, MouriK, ShiroiwaK, Ratta-AphaW, YoshidaM, TamiyaG, SasadaT, EguchiN, OkazakiK, et al. . A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2013, 40: 347-352.

[350] SuwelackD, Hurtado-LorenzoA, MillanE, Gonzalez-NicoliniV, WawrowskyK, LowensteinPR, CastroMG. Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease. Gene Therapy, 2004, 11241742-1752.

[351] SwanbergSE, NagarajanRP, PeddadaS, YasuiDH, LaSalleJM. Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism. Human Molecular Genetics, 2009, 183525-534.

[352] SzvetkoAL, JonesA, MackenzieJ, TajouriL, CsurhesPA, GreerJM, PenderMP, GriffithsLR. An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population. Brain Research, 2009, 1255: 148-152.

[353] TanMG, LeeC, LeeJH, FrancisPT, WilliamsRJ, RamírezMJ, ChenCP, WongPT, LaiMK. Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden. Neurochemistry International, 2014, 64: 29-36.

[354] TanHHG, WestenengHJ, van der BurghHK, van EsMA, BakkerLA, van VeenhuijzenK, van EijkKR, van EijkRPA, VeldinkJH, van den BergLH. The distinct traits of the UNC13A polymorphism in amyotrophic lateral sclerosis. Annals of Neurology, 2020, 884796-806.

[355] TaoR, LiC, NewburnEN, YeT, LipskaBK, HermanMM, WeinbergerDR, KleinmanJE, HydeTM. Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders. Journal of Neuroscience, 2012, 32155216-5222.

[356] TeismannP. COX-2 in the neurodegenerative process of Parkinson's disease. BioFactors, 2012, 386395-397.

[357] TesliM, AthanasiuL, MattingsdalM, KählerAK, GustafssonO, AndreassenBK, WergeT, HansenT, MorsO, MellerupE, et al. . Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample. American Journal of Medical Genetics. Part b, Neuropsychiatric Genetics, 2010, 153B71276-1282.

[358] ThomasPD. The gene ontology and the meaning of biological function. Methods in Molecular Biology, 2017, 1446: 15-24.

[359] TorkamandiS, BahramiS, GhorashiT, DehaniM, BayatH, HoseiniSM, RezaeiS, SoosanabadiM. Dysregulation of long noncoding RNA MEG3 and NLRC5 expressions in patients with relapsing-remitting multiple sclerosis: Is there any correlation?. Genes and Immunity, 2021, 227–8322-326.

[360] TorresA, BrownsteinCA, TembulkarSK, GraberK, GenettiC, KleimanRJ, SweadnerKJ, MavrosC, LiuKX, Smedemark-MarguliesN, et al. . De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. Molecular Genetics and Metabolism Reports, 2018, 16: 23-29.

[361] TrendS, LefflerJ, CooperMN, ByrneSN, KermodeAG, FrenchMA, HartPH. Narrowband UVB phototherapy reduces TNF production by B-cell subsets stimulated via TLR7 from individuals with early multiple sclerosis. Clinical and Translational Immunology, 2020, 910. e1197

[362] TriasE, KovacsM, KingPH, SiY, KwonY, VarelaV, IbarburuS, MouraIC, HermineO, BeckmanJS, et al. . Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis. Glia, 2020, 6861165-1181.

[363] TrojanE, TylekK, SchröderN, KahlI, BrandenburgLO, MastromarinoM, LeopoldoM, Basta-KaimA, LacivitaE. The N-formyl peptide receptor 2 (FPR2) agonist MR-39 improves ex vivo and in vivo amyloid beta (1–42)-induced neuroinflammation in mouse models of Alzheimer's disease. Molecular Neurobiology, 2021, 58126203-6221.

[364] TsilioniI, DodmanN, PetraAI, TaliouA, FrancisK, Moon-FanelliA, ShusterL, TheoharidesTC. Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing Bull Terriers with a phenotype similar to autism. Translational Psychiatry, 2014, 410. e466

[365] TsunokaT, KishiT, KitajimaT, OkochiT, OkumuraT, YamanouchiY, KinoshitaY, KawashimaK, NaitohH, InadaT, et al. . Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010, 344639-644.

[366] TysnesOB, StorsteinA. Epidemiology of Parkinson's disease. Journal of Neural Transmission (Vienna), 2017, 1248901-905.

[367] VallortigaraJ, WhitfieldD, QuelchW, AlghamdiA, HowlettD, HortobágyiT, JohnsonM, AttemsJ, O'BrienJT, ThomasA, et al. . Decreased levels of VAMP2 and monomeric alpha-synuclein correlate with duration of dementia. Journal of Alzheimer's Disease, 2016, 501101-110.

[368] van VeenT, NielsenJ, BerkhofJ, BarkhofF, KamphorstW, BöL, RavidR, VerweijCL, HuitingaI, PolmanCH, et al. . CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis. Journal of Neuroimmunology, 2007, 1901–2157-164.

[369] van AbelD, MichelO, VeerhuisR, JacobsM, van DijkM, OudejansCB. Direct downregulation of CNTNAP2 by STOX1A is associated with Alzheimer's disease. Journal of Alzheimer's Disease, 2012, 314793-800.

[370] Van AckerZP, DeclerckK, LuyckxE, Vanden BergheW, DewildeS. Non-methylation-linked mechanism of REST-induced neuroglobin expression impacts mitochondrial phenotypes in a mouse model of amyotrophic lateral sclerosis. Neuroscience, 2019, 412: 233-247.

[371] Van DerveerAB, BastosG, FerrellAD, GallimoreCG, GreeneML, HolmesJT, KubrickaV, RossJM, HammJP. A Role for somatostatin-positive interneurons in neuro-oscillatory and information processing deficits in schizophrenia. Schizophrenia Bulletin, 2021, 4751385-1398.

[372] VerbeekDS, KnightMA, HarmisonGG, FischbeckKH, HowellBW. Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting. Brain, 2005, 128Pt 2436-442.

[373] VermaR, KubendranS, DasSK, JainS, BrahmachariSK. SYNGR1 is associated with schizophrenia and bipolar disorder in southern India. Journal of Human Genetics, 2005, 5012635-640.

[374] VlaskampDRM, BassettAS, SullivanJE, RobbleeJ, SadleirLG, SchefferIE, AndradeDM. Schizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy. Epilepsia, 2019, 603429-440.

[375] VuL, AnJ, KovalikT, GendronT, PetrucelliL, BowserR. Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes. Journal of Neurology, Neurosurgery and Psychiatry, 2020, 914350-358.

[376] WalkerDG, BeachTG, XuR, LileJ, BeckKD, McGeerEG, McGeerPL. Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease. Brain Research, 1998, 7922207-217.

[377] WangS, GuanY, ChenY, LiX, ZhangC, YuL, ZhouF, WangX. Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice. Biotechnology Letters, 2013, 3581199-1207.

[378] WangY, ImitolaJ, RasmussenS, O'ConnorKC, KhourySJ. Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Annals of Neurology, 2008, 644417-427.

[379] WangP, LiXL, CaoZH. STC1 ameliorates cognitive impairment and neuroinflammation of Alzheimer's disease mice via inhibition of ERK1/2 pathway. Immunobiology, 2021, 2263. 152092

[380] WangL, LiJ, JiaM, YueW, RuanY, LuT, ZhangJ, LiuJ, ZhangD. No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population. Psychiatry Research, 2011, 1902–3369-371.

[381] WangKS, LiuX, AranaTB, ThompsonN, WeismanH, DevargasC, MaoC, SuBB, CamarilloC, EscamillaMA, et al. . Genetic association analysis of ITGB3 polymorphisms with age at onset of schizophrenia. Journal of Molecular Neuroscience, 2013, 512446-453.

[382] WangH, Del MarN, DengY, ReinerA. Rescue of BDNF expression by the thalamic parafascicular nucleus with chronic treatment with the mGluR2/3 agonist LY379268 may contribute to the LY379268 rescue of enkephalinergic striatal projection neurons in R6/2 Huntington's disease mice. Neuroscience Letters, 2021, 763. 136180

[383] WangZ, XuQ, CaiF, LiuX, WuY, SongW. BACE2, a conditional β-secretase, contributes to Alzheimer's disease pathogenesis. JCI Insight, 2019, 41. e123431

[384] WangY, ZhangX, ChenF, ChenL, WangJ, XieJ. LRRK2-NFATc2 pathway associated with neuroinflammation may be a potential therapeutic target for Parkinson's disease. Journal of Inflammation Research, 2021, 14: 2583-2586.

[385] WangL, ZhouY, ChenD, LeeTH. Peptidyl-prolyl cis/trans isomerase Pin1 and Alzheimer's disease. Frontiers in Cell and Developmental Biology, 2020, 8: 355.

[386] WangS, ZhouL, HeC, WangD, CaiX, YuY, ChenL, LuD, BianL, DuS, et al. . The association between STX1B polymorphisms and treatment response in patients with epilepsy. Frontiers in Pharmacology, 2021, 12. 701575

[387] WarburtonA, BreenG, RujescuD, BubbVJ, QuinnJP. Characterization of a REST-regulated internal promoter in the schizophrenia genome-wide associated gene MIR137. Schizophrenia Bulletin, 2015, 413698-707.

[388] WaskoNJ, NicholsF, ClarkRB. Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis. Autoimmunity Reviews, 2020, 191. 102430

[389] WeiL, ChenC, DingL, MoM, ZouJ, LuZ, LiH, WuH, DaiY, XuP, et al. . Wnt1 promotes EAAT2 expression and mediates the protective effects of astrocytes on dopaminergic cells in Parkinson's disease. Neural Plasticity, 2019, 2019: 1247276.

[390] WeissbergO, ElliottE. The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders. Genes (Basel), 2021, 1281133.

[391] WenderskiW, WangL, KrokhotinA, WalshJJ, LiH, ShojiH, GhoshS, GeorgeRD, MillerEL, EliasL, et al. . Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism. Proceedings of the National Academy of Sciences of the United States of America, 2020, 1171810055-10066.

[392] WilcoxJA, QuadriS. Replication of NTNG1 association in schizophrenia. Psychiatric Genetics, 2014, 246266-268.

[393] WilliamsMJ, KlockarsA, ErikssonA, VoisinS, DnyansagarR, WiemerslageL, KasagiannisA, AkramM, KhederS, AmbrosiV, et al. . The drosophila ETV5 homologue Ets96B: molecular link between obesity and bipolar disorder. PLoS Genetics, 2016, 126. e1006104

[394] WilmsdorffMV, BlaichC, ZinkM, TreutleinJ, BauerM, SchulzeT, Schneider-AxmannT, GruberO, RietschelM, SchmittA, et al. . Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment. The World Journal of Biological Psychiatry, 2013, 147490-499.

[395] WojtaKJ, AyerAH, RamosEM, NguyenPD, KarydasAM, YokoyamaJS, KramerJ, LeeSE, BoxerA, MillerBL, et al. . Lack of association between the CCR5-delta32 polymorphism and neurodegenerative disorders. Alzheimer Disease and Associated Disorders, 2020, 343244-247.

[396] WongTH, ChiuWZ, BreedveldGJ, LiKW, VerkerkAJ, HondiusD, HukemaRK, SeelaarH, FrickP, SeverijnenLA, et al. . PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain, 2014, 137Pt 51361-1373.

[397] WongBKY, EhrnhoeferDE, GrahamRK, MartinDDO, LadhaS, UribeV, StanekLM, FranciosiS, QiuX, DengY, et al. . Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. Neurobiology of Diseases, 2015, 76: 24-36.

[398] WoollardPM, MehtaNA, VamathevanJJ, Van HornS, BondeBK, DowDJ. The application of next-generation sequencing technologies to drug discovery and development. Drug Discovery Today, 2011, 1611–12512-519.

[399] WuHC, ChenCM, ChenYC, FungHC, ChangKH, WuYR. DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population. Neurobiology of Aging, 2018, 64: 158.e1-158.e6.

[400] WuYE, ParikshakNN, BelgardTG, GeschwindDH. Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder. Nature Neuroscience, 2016, 19111463-1476.

[401] XiZ, DengW, WangL, XiaoF, LiJ, WangZ, WangX, MiX, WangN, WangX. Association of alpha-soluble NSF attachment protein with epileptic seizure. Journal of Molecular Neuroscience, 2015, 573417-425.

[402] XiaoMF, RohSE, ZhouJ, ChienCC, LuceyBP, CraigMT, HayesLN, CoughlinJM, LewekeFM, JiaM, et al. . A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function. Science Advance, 2021, 748935.

[403] XuY, ChengL, SunJ, LiF, LiuX, WeiY, HanM, ZhuZ, BiJ, LaiC, et al. . Hypermethylation of mitochondrial cytochrome b and cytochrome c oxidase II genes with decreased mitochondrial DNA copy numbers in the APP/PS1 transgenic mouse model of Alzheimer's disease. Neurochemical Research, 2021, 463564-572.

[404] XuL, LiJ, TianD, ChenL, TangL, FanD. The rs696880 polymorphism in the nogo-A receptor gene (RTN4R) is associated with susceptibility to sporadic amyotrophic lateral sclerosis in the chinese population. Frontiers in Aging Neuroscience, 2018, 10: 108.

[405] XuFL, YaoJ, WuX, XiaX, XingJX, XuanJF, LiuYP, WangBJ. Association analysis between SNPs in the promoter region of RGS4 and schizophrenia in the Northern Chinese Han population. Neuropsychiatric Disease and Treatment, 2020, 16: 985-992.

[406] XuM, ZhangDF, LuoR, WuY, ZhouH, KongLL, BiR, YaoYG. A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease. Alzheimer's & Dementia, 2018, 142215-229.

[407] YamamotoT, MurayamaS, TakaoM, IsaT, HigoN. Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord: Changes in patients with amyotrophic lateral sclerosis. Brain Research, 2017, 1655: 168-175.

[408] YamamotoA, SuzukiT, SakakiY. Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. Gene, 2001, 2712159-169.

[409] YangL, ChenJ, LiY, WangY, LiangS, ShiY, ShiS, XuY. ssociation between SCAP and SREBF1 gene polymorphisms and metabolic syndrome in schizophrenia patients treated with atypical antipsychotics. World Journal of Biological Psychiatry, 2016, 176467-474.

[410] YoungN, AsifM, JacksonM, Fernández-MayoralasDM, de la PeñaMJ, Calleja-PérezB, ÁlvarezS, Hunter-FeatherstoneE, NoegelAA, HöhneW, et al. . Biallelic SYNE2 missense mutations leading to nesprin-2 giant hypo-expression are associated with intellectual disability and autism. Genes (Basel)., 2021, 1291294.

[411] YuanX, CaoB, WuY, ChenY, WeiQ, OuR, YangJ, ChenX, ZhaoB, SongW, et al. . Association analysis of SNP rs11868035 in SREBF1 with sporadic Parkinson's disease, sporadic amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population. Neuroscience Letters, 2018, 664: 128-132.

[412] YuanX, TianY, LiuC, ZhangZ. Environmental factors in Parkinson's disease: New insights into the molecular mechanisms. Toxicology Letters, 2022, 356: 1-10.

[413] ZakharyanR, KhoyetsyanA, ArakelyanA, BoyajyanA, GevorgyanA, StahelovaA, MrazekF, PetrekM. Association of C1QB gene polymorphism with schizophrenia in Armenian population. BMC Medical Genetics, 2011, 12: 126.

[414] ZakiN, EfimovD, BerengueresJ. Protein complex detection using interaction reliability assessment and weighted clustering coefficient. BMC Bioinformatics, 2013, 14: 163.

[415] ZhangDF, FanY, XuM, WangG, WangD, LiJ, KongLL, ZhouH, LuoR, BiR, et al. . Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese. National Science Review, 2019, 62257-274.

[416] ZhangY, SunHM, HeX, WangYY, GaoYS, WuHX, XuH, GongXG, GuoZY. Da-Bu-Yin-Wan and Qian-Zheng-San, two traditional Chinese herbal formulas, up-regulate the expression of mitochondrial subunit NADH dehydrogenase 1 synergistically in the mice model of Parkinson's disease. Journal of Ethnopharmacology, 2013, 1461363-371.

[417] ZhangT, TangY, YangX, WangX, DingS, HuangK, LiuY, LangB. Expression of GSK3β, PICK1, NEFL, C4, NKCC1 and Synaptophysin in peripheral blood mononuclear cells of the first-episode schizophrenia patients. Asian Journal of Psychiatry, 2021, 55. 102520

[418] ZhangW, WangLZ, YuJT, ChiZF, TanL. Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer's disease. Journal of the Neurological Sciences, 2012, 3151–267-71.

[419] ZhangY, XuC, NanY, NanS. Microglia-derived extracellular vesicles carrying miR-711 alleviate neurodegeneration in a murine alzheimer's disease model by binding to itpkb. Frontiers in Cell and Developmental Biology, 2020, 8. 566530

[420] ZhangX, ZhuC, BeechamG, VardarajanBN, MaY, LancourD, FarrellJJ, ChungJ. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease. Alzheimer's and Dementia, 2019, 153441-452.

[421] ZhaoMW, QiuWJ, YangP. SP1 activated-lncRNA SNHG1 mediates the development of epilepsy via miR-154-5p/TLR5 axis. Epilepsy Research, 2020, 168. 106476

[422] ZhaoLJ, WangZT, MaYH, ZhangW, DongQ, YuJT, TanL. Associations of the cerebrospinal fluid hepatocyte growth factor with Alzheimer's disease pathology and cognitive function. BMC Neurology, 2021, 211387.

[423] ZhengC, ChenJ, ChuF, ZhuJ, JinT. Inflammatory role of TLR-MyD88 signaling in multiple sclerosis. Frontiers in Molecular Neuroscience, 2020, 12: 314.

[424] ZhouG, SoufanO, EwaldJ, HancockREW, BasuN, XiaJ. NetworkAnalyst 3.0: A visual analytics platform for comprehensive gene expression profiling and meta-analysis. Nucleic Acids Research, 2019, 47: W234-W241.

[425] ZhuangX, ChenY, ZhuangX, ChenT, XingT, WangW, YangX. Contribution of pro-inflammatory cytokine signaling within midbrain periaqueductal gray to pain sensitivity in Parkinson's disease via GABAergic pathway. Frontiers in Neurology, 2016, 7: 104.

RIGHTS & PERMISSIONS

Shenzhen University School of Medicine; Fondazione Istituto FIRC di Oncologia Molecolare