Fetuin-A: A novel protector of hematopoietic stem cell genomic stability

Abstract

Embryonic development is a complex process involving the rapid and precise proliferation of cells. Maintaining genome integrity is critical for normal development. Research on the mechanisms by which the tissue microenvironment preserves genomic stability during development, however, is scarce. Now, a study by Dengli Hong et al., published in Nature journal provides a novel perspective for understanding the mechanisms of genomic protection in embryonic liver development. Here, we discuss the data that explains how embryonic liver cells can regulate the genomic stability of hematopoietic stem cells through fetuin-A.

Keywords

Fetuin-A / Genomic integrity / Hematopoietic stem cell / DNA damage / Biological Sciences / Biochemistry and Cell Biology / Genetics

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RIGHTS & PERMISSIONS

Shenzhen University School of Medicine; Fondazione Istituto FIRC di Oncologia Molecolare