Identification of novel phytotherapeutic agents for understanding hypertrophic cardiomyopathy via genetic mapping and advanced computational analysis

Abdullahi Tunde Aborode; Onifade Isreal Ayobami; Ammar Usman Danazumi; Christopher Busayo Olowosoke; Haruna Isiyaku Umar; Abraham Osinuga; Aeshah A. Awaji; Fatmah Ali Awaji; Ebenezer Ayomide Omojowolo; Najwa Ahmad Kuthi; Tanveer Shaikh; Babatunde Shuaib Anidu; Athanasios Alexiou; Ridwan Olamilekan Adesola; Zainab Olapade; Awah Favour Matthew; Blessing Ameh; Toluwalope Yinka Oni; Adetolase Azizat Bakre; Godfred Yawson Scott

doi:10.1007/s42764-024-00141-9

Genome Instability & Disease ›› : 1 -25. DOI: 10.1007/s42764-024-00141-9

Original Research Paper

Identification of novel phytotherapeutic agents for understanding hypertrophic cardiomyopathy via genetic mapping and advanced computational analysis

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¹Department of Chemistry, Mississippi State University, 39759, Starkville, MS, USA

²Department of Biology, University at Albany, Albany, NY, USA

³Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland

⁴Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands

⁵Department of Biotechnology, Federal University of Technology, P. M. B. 704Akure, Ondo State, Nigeria

⁶Computer-Aided Therapeutic Discovery and Design Group, FUTA, Akure, Nigeria

⁷Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, USA

⁸Department of Biology, Faculty of Science, University College of Taymaa, University of Tabuk, 71491, Tabuk, Saudi Arabia

⁹King Fahad Specialist Hospital Laboratory and Blood Bank Health Cluster, Tabuk, Saudi Arabia

¹⁰Department of Chemistry, University of Albany, State University of New York, 12222, Albany, NY, USA

¹¹Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), Johor Bahru, Johor, Malaysia

¹²Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA

¹³Department of Science and Engineering, Novel Global Community Educational Foundation, 2770, Hebersham, NSW, Australia

¹⁴AFNP Med, 1030, Wien, Austria

¹⁵Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria

¹⁶Department of Biology, Lamar University, Texas, USA

¹⁷Department of Biochemistry, Center for Discovery and Innovation, City University of New York, New York, NY, USA

¹⁸University of West Georgia, Carrolton, GA, USA

¹⁹Department of Biochemistry, Federal University of Technology, Akure, Nigeria

²⁰Department of Medical Diagnostics, Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Corresponding author:

^a gyscott.edu@gmail.com

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Abstract

Hypertrophic cardiomyopathy (HCM) is a monogenic cardiovascular disorder that has been poorly studied at the molecular, genetic, and computational levels. Here, we examined the genetic map of HCM polymorphic targets using a computational approach to identify new phytochemicals with potential therapeutic properties. We demonstrate the range of mutations associated with cardiomyopathies, and identify new associations between genes and phenotypes in this disease category. Specifically, our findings suggest that several genes associated with channelopathies might serve as genetic modifiers, altering the clinical features and severity of cardiomyopathic phenotypes, thus likely impacting disease manifestation.

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Abdullahi Tunde Aborode, Onifade Isreal Ayobami, Ammar Usman Danazumi, Christopher Busayo Olowosoke, Haruna Isiyaku Umar, Abraham Osinuga, Aeshah A. Awaji, Fatmah Ali Awaji, Ebenezer Ayomide Omojowolo, Najwa Ahmad Kuthi, Tanveer Shaikh, Babatunde Shuaib Anidu, Athanasios Alexiou, Ridwan Olamilekan Adesola, Zainab Olapade, Awah Favour Matthew, Blessing Ameh, Toluwalope Yinka Oni, Adetolase Azizat Bakre, Godfred Yawson Scott. Identification of novel phytotherapeutic agents for understanding hypertrophic cardiomyopathy via genetic mapping and advanced computational analysis. Genome Instability & Disease 1-25 DOI:10.1007/s42764-024-00141-9

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