Exploring the DNA damage response pathway for synthetic lethality
Xin Xu , Somaira Nowsheen , Min Deng
Genome Instability & Disease ›› 2022, Vol. 4 ›› Issue (2) : 98 -120.
Exploring the DNA damage response pathway for synthetic lethality
Synthetic lethality (SL) describes a situation in which the occurrence of one genetic event maintains cell viability, whereas the co-occurrence of two genetic events lead to cell death. DNA damage response (DDR) pathway represents the most attractive synthetic lethality targets, since genomic instability is a hallmark of cancers due to the accumulation of DNA mutation during the process of DNA damage response. The definition of synthetic lethality will help to target cancer cells precisely and tackle the undruggable targets. In recent years, the success of DNA damage response inhibitors in cancer treatment highlights the potential of this approach. In this review, we will highlight the concept of synthetic lethality, strategy as well as the most recent development in this area.
Central Research Institute Fund of Chinese Academy of Medical Sciences(2021-RC310-013)
Beijing Hope Run Special Fund of Cancer Foundation of China(LC2021R02)
CAMS Innovation Fund for Medical Sciences(2021-I2M-1-067)
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