G-quadruplex and 8-oxo-7,8-dihydroguanine across the genome: methodologies and crosstalk
Jiao An , Mengdie Yin , Jinchuan Hu
Genome Instability & Disease ›› 2022, Vol. 3 ›› Issue (5) : 241 -254.
G-quadruplex and 8-oxo-7,8-dihydroguanine across the genome: methodologies and crosstalk
G-quadruplex (G4) is a non-canonical DNA second structure formed on specific G-rich sequences which are enriched in transcriptional regulatory regions and telomeres. This structure is involved in multiple cellular processes including transcription regulation and genome integrity. On the other hand, G-rich regions are hotspots of oxidative damage, since G has the lowest redox potential among the four nucleobases, and the 5’G of a G stretch has an even lower ionization potential. Evidence emerged recently that the most common oxidative damage, 8-oxo-7,8-dihydroguanine (OG), plays an epigenetic-like role to regulate transcription. Therefore, G4 and OG may co-localize at G-rich regions and interact with each other to regulate transcription. In this review, we summarize recent advantages about genome-wide mapping of G4 and OG, and discuss their crosstalk at genomic level.
National Natural Science Foundation of China(31870804)
National Natural Science Foundation of China(21807013)
Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning(2019)
Shanghai Outstanding Young Talent Program(2019)
innovative research team of high-level local university in Shanghai, Shanghai Municipal Natural Science Foundation(22ZR1413900)
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