FAM135B: a new player in DNA damage response

Chunyu Song; Lin Deng

doi:10.1007/s42764-022-00079-w

Genome Instability & Disease ›› 2022, Vol. 3 ›› Issue (5) : 238 -240. DOI: 10.1007/s42764-022-00079-w

Review Article

FAM135B: a new player in DNA damage response

Chunyu Song ¹^,²
, Lin Deng ¹^,²^,^b

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Abstract

The ATM (Ataxia telangiectasia mutated) kinase and its complex with TIP60 could rapidly respond to DNA double-strand breaks. But the molecular mechanism remains elusive. New research identifies FAM135B as a novel regulator of TIP60-ATM axis. FAM135B interacts with and maintains the TIP60-ATM reservoir in resting condition, whereas it dissociates from the complex and degrades, allowing cells to respond to DNA damage. This work reveals a direct link between the steady-state organization of ATM and the kinetics of its activation after DNA damage.

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Chunyu Song, Lin Deng. FAM135B: a new player in DNA damage response. Genome Instability & Disease, 2022, 3(5): 238-240 DOI:10.1007/s42764-022-00079-w