MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer

Jie Ding; Yifan Wen; Xu Yuan; Xianghuo He

doi:10.1007/s42764-022-00078-x

Genome Instability & Disease ›› 2022, Vol. 4 ›› Issue (2) : 47-69. DOI: 10.1007/s42764-022-00078-x

Review Article

MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer

Jie Ding¹ ,
Yifan Wen¹ ,
Xu Yuan¹ ,
Xianghuo He¹^,²^,³^,^d

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Abstract

Cancer cells possess a unique metabolic phenotype, rewiring their metabolic pathways to support energy-intensive and biosynthetic requirements for exuberant proliferation and migration. Attention has focused on the role of microRNAs (miRNAs) in mediating metabolic shifts in cancer cells. miRNAs participate in cancer metabolism reprogramming mainly by directly silencing the expression of specific genes. This review focuses on miRNA regulation of cancer metabolic reprogramming, including glucose, fatty acid and amino acid metabolism, and allows a deeper understanding of importance of miRNAs in tumorigenesis and progression, therefore, providing new avenues for cancer therapy strategy.

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Jie Ding, Yifan Wen, Xu Yuan, Xianghuo He. MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer. Genome Instability & Disease, 2022, 4(2): 47‒69 https://doi.org/10.1007/s42764-022-00078-x

Funding

the National Natural Science Foundation of China(81930123); Innovative Research Group Project of the National Natural Science Foundation of China(81790252); the National Natural Science Foundation of China(82121004)