Aberrant DNA methylation in t(8;21) acute myeloid leukemia
Shujiao He , Jingfeng Zhou , Li Yu
Genome Instability & Disease ›› 2022, Vol. 3 ›› Issue (4) : 209 -216.
Aberrant DNA methylation in t(8;21) acute myeloid leukemia
Aberrant DNA methylation is a hallmark of acute myeloid leukemia (AML). Various studies showed that t(8;21) AML presented a distinct DNA methylation profile and could be categorized into a separate cluster according to DNA methylation sequencing. Yet, there is still a lack of understanding regarding the causes and mechanisms of this phenomenon. Knowing how the DNA methylation is regulated in t(8;21) AML would enhance our understanding of leukemogenesis and may assist clinical decision-making regarding DNA methylation-targeted therapy. Herein, we summarized our current knowledge concerning DNA methylation regulation in t(8;21) AML and discussed their potential clinical significance in this article.
Innovative Research Group Project of the National Natural Science Foundation of China(2019ZX09201002003)
National Natural Science Foundation of China(82030076)
Shenzhen Science and Technology Innovation Program(JCYJ20190808163601776)
Shenzhen Key Laboratory Fund(ZDSYS20200811143757022)
Sanming Project of Medicine in Shenzhen(SZSM202111004)
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