Long non-coding RNAs regulate fatty acid and cholesterol metabolism

Kai Lei; Lei Qu; Fangzhou Liu; Ninghui Hao; Jincheng Chen; Jian Liu; Aifu Lin

doi:10.1007/s42764-022-00070-5

Genome Instability & Disease ›› 2022, Vol. 3 ›› Issue (2) : 70-82. DOI: 10.1007/s42764-022-00070-5

Review Article

Long non-coding RNAs regulate fatty acid and cholesterol metabolism

Kai Lei¹ ,
Lei Qu¹ ,
Fangzhou Liu¹ ,
Ninghui Hao²^,³ ,
Jincheng Chen²^,³ ,
Jian Liu²^,³^,^f ,
Aifu Lin¹^,⁴^,⁵^,⁶^,⁷^,^g

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Abstract

In recent years, long non-coding RNAs (lncRNAs) have emerged as critical players in regulating biological processes at various levels. LncRNAs modulate the target genes through interacting with DNA, RNA, or protein, which have been found to regulate various physiological and pathological activities. Current studies have reported lncRNAs played an important role in lipid metabolism via diverse pathways. Dysregulation of lipid metabolism is closely related to various metabolic diseases, including obesity, fatty liver disease, and cancer. To further understand the mechanisms of lncRNAs in lipid metabolism, we focus on the role of lncRNAs in fatty acid and cholesterol biosynthesis, catabolism, and transferring, aiming to exploit relevant signaling pathways.

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Kai Lei, Lei Qu, Fangzhou Liu, Ninghui Hao, Jincheng Chen, Jian Liu, Aifu Lin. Long non-coding RNAs regulate fatty acid and cholesterol metabolism. Genome Instability & Disease, 2022, 3(2): 70‒82 https://doi.org/10.1007/s42764-022-00070-5

Funding

National Key R&D Program of China(2021YFC2700903); National Natural Science Foundation of China(81872300); Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars(LR18C060002)