SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA
Chenzhong Xu , Jin Zhang , Jie Zhang , Baohua Liu
Genome Instability & Disease ›› 2021, Vol. 2 ›› Issue (4) : 253 -260.
SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA
N-acetyltransferase 10 catalyzes RNA N4-acetylcytidine (ac4C) modifications and thus regulates RNA stability and translation efficiency. However, the deacetylase for ac4C is unknown. SIRT7 was initially identified as an NAD+-dependent protein deacetylase and plays essential roles in genome stability, circadian rhythms, metabolism, and aging. In this study, we identified SIRT7 as a deacetylase of the ac4C of ribosomal (r)RNA for the first time and found it to be NAD+-independent. Our data highlight the important role of SIRT7 in rRNA ac4C modification and suggest an additional epitranscriptional regulation of aging.
national natural science foundation of china(32090030)
key technologies research and development program(2017YFA0503900)
science and technology planning project of shenzhen municipality(ZDSYS20190902093401689, KQJSCX20180328093403969 and JCYJ20180507182044945)
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