SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA

Chenzhong Xu; Jin Zhang; Jie Zhang; Baohua Liu

doi:10.1007/s42764-021-00046-x

Genome Instability & Disease ›› 2021, Vol. 2 ›› Issue (4) : 253-260. DOI: 10.1007/s42764-021-00046-x

Short Communication

SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA

Chenzhong Xu¹ ,
Jin Zhang¹ ,
Jie Zhang² ,
Baohua Liu¹^,³^,^d

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Abstract

N-acetyltransferase 10 catalyzes RNA N4-acetylcytidine (ac4C) modifications and thus regulates RNA stability and translation efficiency. However, the deacetylase for ac4C is unknown. SIRT7 was initially identified as an NAD⁺-dependent protein deacetylase and plays essential roles in genome stability, circadian rhythms, metabolism, and aging. In this study, we identified SIRT7 as a deacetylase of the ac4C of ribosomal (r)RNA for the first time and found it to be NAD⁺-independent. Our data highlight the important role of SIRT7 in rRNA ac4C modification and suggest an additional epitranscriptional regulation of aging.

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Chenzhong Xu, Jin Zhang, Jie Zhang, Baohua Liu. SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA. Genome Instability & Disease, 2021, 2(4): 253‒260 https://doi.org/10.1007/s42764-021-00046-x

Funding

national natural science foundation of china(82061160495); key technologies research and development program(2017YFA0503900); science and technology planning project of shenzhen municipality(ZDSYS20190902093401689, KQJSCX20180328093403969 and JCYJ20180507182044945)