Nuclear envelope integrity, DNA replication, damage repair and genome stability

Abstract

The nuclear envelope (NE) not only shields the genetic material inside the nucleus, maintains the dynamic shapes of nucleus, and regulates nuclear exchange with cytosol, but also participates in DNA replication, damage repair and transcription regulation. The loss of NE integrity, as observed in various diseases, has been shown to cause genome instability as a result of genetic material leaking into the cytoplasm. An underestimated but critically important factor of genome integrity is the role of NE components that involve in DNA replication and damage repair. In this review, we summarize the triggers of NE loss and its cellular consequences by focusing on the interactions between NE components and DNA replication and repair factors. Studies on how NE mediates DNA replication and damage repair could shed light on the diagnosis and treatment of human diseases such as cancer and laminopathy.

Funding

Guangdong Basic and Applied Basic Research Foundation(2020A1515110542); National Natural Science Foundation of China(31970752); Science, Technology and Innovation Commission of Shenzhen Municipality(JSGG20191129110812); Shenzhen Bay Laboratory Open Fund(SZBL2020090501004)