Health economics in cervical cancer prevention: A bibliometric analysis of HPV vaccination cost-effectiveness in Brazil

Abstract

Vaccination against human papillomavirus (HPV) is a key strategy for preventing cervical cancer, particularly in developing countries such as Brazil, where the disease remains a significant public health challenge. Despite well-established clinical efficacy, there is still limited systematic evidence regarding the cost-effectiveness of this intervention in the Brazilian context. This study aims to analyze the scientific production on the cost-effectiveness of HPV vaccination in cervical cancer prevention through a bibliometric approach. Searches were conducted in Scopus, Web of Science, and PubMed/MEDLINE for comparison, and the bibliometric analysis was performed using the Scopus dataset. The results indicate a significant growth in scientific production over time, structured around three main thematic areas: economic modeling, the social impact of immunization, and integration with public health policies. However, Brazilian scientific output remains limited, particularly regarding economic evaluations within the Unified Health System (SUS), highlighting important gaps in national research. These findings reinforce the importance of strengthening local scientific production and expanding evidence on cost-effectiveness to support more efficient and sustainable public health policies. Bibliometric analysis proves to be a useful tool for identifying trends, gaps, and collaboration patterns, contributing to more informed decision-making in immunization strategies.

Keywords

Health economics / Prevention / Cervical cancer / Bibliometric analysis / Cost-effectiveness / Human papillomavirus

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