Saponins Based on Medicinal and Edible Homologous Plants: Biological Activity, Delivery Systems and Its Application in Healthy Foods

Siwen Chen , Ying Zhou , Huiliang Li , Lijun You , Sandra Pedisić , Ping Shao

Food Bioengineering ›› 2024, Vol. 3 ›› Issue (4) : 464 -481.

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Food Bioengineering ›› 2024, Vol. 3 ›› Issue (4) : 464 -481. DOI: 10.1002/fbe2.12111
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Saponins Based on Medicinal and Edible Homologous Plants: Biological Activity, Delivery Systems and Its Application in Healthy Foods

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Abstract

Medicinal and edible homologous (MEHs) plants are valuable in medicine and food science as edible plants. Saponins, one of the major chemical components isolated from MEHs plants, have significant antioxidant, anti-inflammatory, antibacterial, and antiviral biological activities. This paper provides an overview of the basic structure, properties, and bioactivity of saponins, the development of novel delivery systems for their enhanced bioavailability, and their applications in various fields. It also highlights the innovations and challenges of current trends in saponin research and provides a basis for the development of a safe and effective natural active ingredient based on MEHs plants. Through comprehensive analysis, this paper aims to provide a theoretical basis and technical support for further research and application of saponins in food science.

Keywords

biological activities / healthy foods / novel delivery systems / saponins

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Siwen Chen, Ying Zhou, Huiliang Li, Lijun You, Sandra Pedisić, Ping Shao. Saponins Based on Medicinal and Edible Homologous Plants: Biological Activity, Delivery Systems and Its Application in Healthy Foods. Food Bioengineering, 2024, 3(4): 464-481 DOI:10.1002/fbe2.12111

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References

[1]

Araviiskaia, E., and B. Dréno. 2016. “The Role of Topical Dermocosmetics in Acne Vulgaris.” Journal of the European Academy of Dermatology and Venereology 30, no. 6: 926–935.

[2]

Bai, J., X. Zhang, W. Meng, et al. 2024. “Dioscin Decreases M2 Polarization via Inhibiting a Positive Feedback Loop Between RBM47 and NF-κB in Glioma.” Phytomedicine 128: 155417.

[3]

Bai, M., G.-D. Yao, Q. Ren, et al. 2018. “Triterpenoid Saponins and Flavonoids From Licorice Residues With Anti-Inflammatory Activity.” Industrial Crops and Products 125: 50–58.

[4]

Bai, X., R. Fu, Z. Duan, P. Wang, C. Zhu, and D. Fan. 2021. “Ginsenoside Rk3 Alleviates Gut Microbiota Dysbiosis and Colonic Inflammation in Antibiotic-Treated Mice.” Food Research International 146: 110465.

[5]

Bakr, A. F., P. Shao, and M. A. Farag. 2022. “Recent Advances in Glycyrrhizin Metabolism, Health Benefits, Clinical Effects and Drug Delivery Systems for Efficacy Improvement; A Comprehensive Review.” Phytomedicine 99: 153999.

[6]

Bao, S., T. Chen, J. Chen, et al. 2023. “Multi-Omics Analysis Reveals the Mechanism of Action of Ophiopogonin D Against Pulmonary Fibrosis.” Phytomedicine 121: 155078.

[7]

Burguera, J. L., and M. Burguera. 2012. “Analytical Applications of Emulsions and Microemulsions.” Talanta 96: 11–20.

[8]

Cai, W., S. Xu, T. Ma, X. Zhang, B. Liu, and F. Xu. 2021. “Five Novel Triterpenoid Saponins From Hovenia dulcis and Their Nrf2 Inhibitory Activities.” Arabian Journal of Chemistry 14, no. 8: 103292.

[9]

Chang, Y., S. Wang, J. Xu, et al. 2023. “Optimization of Extraction Process of Dioscorea nipponica Makino Saponins and Their UPLC-QTOF-MS Profiling, Antioxidant, Antibacterial and Anti-Inflammatory Activities.” Arabian Journal of Chemistry 16, no. 4: 104630.

[10]

Chen, X.-W., T.-G. Wang, W.-J. Yin, L.-S. Zhang, and S.-D. Sun. 2024. “All-Natural Plant-Based HIPE-Gels Simultaneously Stabilizing With Quillaja saponin and Soy Protein Isolate: Influence of Environmental Stresses on Stability.” Food Hydrocolloids 151: 109880.

[11]

Chen, X. W., W. J. Yin, D. X. Yang, Z. L. Wan, C. G. Ma, and X. Q. Yang. 2021. “One-Pot Ultrasonic Cavitational Emulsification of Phytosterols Oleogel-Based Flavor Emulsions and Oil Powder Stabilized by Natural Saponin.” Food Research International 150, Pt A: 110757.

[12]

Chen, X. W., H. Zhang, X. X. Li, and S. D. Sun. 2023. “Edible HIPE-Gels and Oleogels Formed by Synergistically Combining Natural Triterpenoid Saponin and Citrus Dietary Fiber.” Carbohydrate Polymers 305: 120499.

[13]

Chen, Y., H. Nie, H. Dong, et al. 2023. “Revealing the Mechanism Underlying the Effects of γ-Aminobutyric Acid-Dioscorin Interactions on Dioscorin Structure and Emulsifying Properties by Molecular Dynamic Simulations.” Food Research International 171: 112982.

[14]

Cheng-Yuan, W., and D. Jian-Gang. 2023. “Research Progress on the Prevention and Treatment of Hyperuricemia by Medicinal and Edible Plants and Its Bioactive Components.” Frontiers in Nutrition 10: 1186161.

[15]

Cheok, C. Y., H. A. K. Salman, and R. Sulaiman. 2014. “Extraction and Quantification of Saponins: A Review.” Food Research International 59: 16–40.

[16]

Dai, Z., P. F. Zhu, H. Liu, et al. 2022. “Discovery of Potent Immune-Modulating Molecule Taccaoside A Against Cancers From Structures-Active Relationships of Natural Steroidal Saponins.” Phytomedicine 104: 154335.

[17]

Du, J. R., F. Y. Long, and C. Chen. 2014. “Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer.” Enzymes 36: 95–130.

[18]

Duan, Y., W. Du, Z. Song, et al. 2023. “Functional Characterization of a Cycloartenol Synthase and Four Glycosyltransferases in the Biosynthesis of Cycloastragenol-Type Astragalosides From Astragalus membranaceus.” Acta Pharmaceutica Sinica B 13, no. 1: 271–283.

[19]

Fang, Z., J. Li, R. Yang, L. Fang, and Y. Zhang. 2020. “A Review: The Triterpenoid Saponins and Biological Activities of Lonicera Linn.” Molecules 25, no. 17: 3773.

[20]

Feng, L., L. Wang, C. Hu, and X. Jiang. 2010. “Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Ginsenoside Rg1 in Rats.” Archives of Pharmacal Research 33, no. 12: 1975–1984.

[21]

Giménez-Ribes, G., M. Habibi, and L. M. C. Sagis. 2020. “Interfacial Rheology and Relaxation Behavior of Adsorption Layers of the Triterpenoid Saponin Escin.” Journal of Colloid and Interface Science 563: 281–290.

[22]

Gong, X., X. Li, Y. Xia, et al. 2020. “Effects of Phytochemicals From Plant-Based Functional Foods on Hyperlipidemia and Their Underpinning Mechanisms.” Trends in Food Science & Technology 103: 304–320.

[23]

Guo, X., W. Luo, L. Wu, et al. 2024. “Natural Products from Herbal Medicine Self-Assemble into Advanced Bioactive Materials.” Advanced Science 11: 2403388.

[24]

Guo, M., C. Zhu, R. Fu, X. Ma, Z. Duan, and D. Fan. 2023. “Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.” Journal of Agricultural and Food Chemistry 71, no. 24: 9370–9380.

[25]

Heng, L., J. P. Vincken, K. Hoppe, et al. 2006. “Stability of pea DDMP Saponin and the Mechanism of Its Decomposition.” Food Chemistry 99, no. 2: 326–334.

[26]

Herrera-Balandrano, D. D., Z. Chai, T. Beta, J. Feng, and W. Huang. 2021. “Blueberry Anthocyanins: An Updated Review on Approaches to Enhancing Their Bioavailability.” Trends in Food Science & Technology 118: 808–821.

[27]

Hong, C., D. Wang, J. Liang, et al. 2019. “Novel Ginsenoside-Based Multifunctional Liposomal Delivery System for Combination Therapy of Gastric Cancer.” Theranostics 9, no. 15: 4437–4449.

[28]

Hosseini, H., and S. M. Jafari. 2020. “Introducing Nano/Microencapsulated Bioactive Ingredients for Extending the Shelf-Life of Food Products.” Advances in Colloid and Interface Science 282: 102210.

[29]

Hou, Y. J., Y. Q. Luo, Q. Li, et al. 2024. “A New Multi-Template Molecularly Imprinted Polymer for Separation and Purification of Dioscin, Protodioscin, and Diosgenin From Purple Yam.” Food Chemistry 442: 138434.

[30]

Hu, Q., H. Hong, Z. Zhang, et al. 2023. “Methods on Improvements of the Poor Oral Bioavailability of Ginsenosides: Pre-Processing, Structural Modification, Drug Combination, and Micro- or Nano-Delivery System.” Journal of Ginseng Research 47, no. 6: 694–705.

[31]

Huang, L., Z. Sun, Q. Shen, et al. 2022. “Rational Design of Nanocarriers for Mitochondria-Targeted Drug Delivery.” Chinese Chemical Letters 33, no. 9: 4146–4156.

[32]

Jin, X., C. Wei, C. Wu, and W. Zhang. 2022. “Gastric Fluid-Induced Double Network Hydrogel With High Swelling Ratio and Long-Term Mechanical Stability.” Composites, Part B: Engineering 236: 109816.

[33]

Jolly, A., H. Kim, J.-Y. Moon, A. Mohan, and Y.-C. Lee. 2023. “Exploring the Imminent Trends of Saponins in Personal Care Product Development: A Review.” Industrial Crops and Products 205: 117489.

[34]

Ju, J. H., T. E. Lee, J. Lee, T. H. Kim, K. C. Shin, and D. K. Oh. 2021. “Improved Bioactivity of 3-O-β-D-Glucopyranosyl Platycosides in Biotransformedplatycodon Grandiflorumroot Extract by Pectinase From Aspergillus aculeatus.” Journal of Microbiology and Biotechnology 31, no. 6: 847–854.

[35]

Kallscheuer, N., R. Menezes, A. Foito, et al. 2019. “Identification and Microbial Production of the Raspberry Phenol Salidroside That Is Active Against Huntington’s Disease.” Plant Physiology 179, no. 3: 969–985.

[36]

Kang, S. H., T. H. Kim, K. C. Shin, Y. J. Ko, and D. K. Oh. 2019. “Biotransformation of Food-Derived Saponins, Platycosides, Into Deglucosylated Saponins Including Deglucosylated Platycodin D and Their Anti-Inflammatory Activities.” Journal of Agricultural and Food Chemistry 67, no. 5: 1470–1477.

[37]

Kim, H., D. Bai, S. Ghosh, et al. 2022. “Structure-Activity Relationship Study of Momordica Saponin II Derivatives as Vaccine Adjuvants.” Journal of Medicinal Chemistry 65, no. 21: 14589–14598.

[38]

Kim, K. T., M. H. Kim, J. H. Park, et al. 2018. “Microemulsion-Based Hydrogels for Enhancing Epidermal/Dermal Deposition of Topically Administered 20(S)-Protopanaxadiol: In Vitro and In Vivo Evaluation Studies.” Journal of Ginseng Research 42, no. 4: 512–523.

[39]

Kumar, R., and A. Parashar. 2023. “Atomistic Simulations of Pristine and Nanoparticle Reinforced Hydrogels: A Review.” WIREs Computational Molecular Science 13, no. 4.

[40]

Lan, X., K. Deng, J. Zhao, et al. 2017. “New Triterpenoid Saponins From Green Vegetable Soya Beans and Their Anti-Inflammatory Activities.” Journal of Agricultural and Food Chemistry 65, no. 50: 11065–11072.

[41]

Lee, J. O., S. H. Hwang, T. Shen, et al. 2021. “Enhancement of Skin Barrier and Hydration-Related Molecules by Protopanaxatriol in Human Keratinocytes.” Journal of Ginseng Research 45, no. 2: 354–360.

[42]

Lee, S., S. M. Lee, S. H. Lee, et al. 2023. “In Situ Photo-Crosslinkable Hyaluronic Acid-Based Hydrogel Embedded With GHK Peptide Nanofibers for Bioactive Wound Healing.” Acta Biomaterialia 172: 159–174.

[43]

Lee, S. M. 2014. “Anti-Inflammatory Effects of Ginsenosides Rg5, Rz1, and Rk1: Inhibition of TNF-α-Induced NF-κB, COX-2, and iNOS Transcriptional Expression.” Phytotherapy Research 28, no. 12: 1893–1896.

[44]

Lee, S. Y., S. I. Jeon, S. B. Sim, Y. Byun, and C. H. Ahn. 2021. “A Supramolecular Host-Guest Interaction-Mediated Injectable Hydrogel System With Enhanced Stability and Sustained Protein Release.” Acta Biomaterialia 131: 286–301.

[45]

Leggio, L., G. Arrabito, V. Ferrara, et al. 2020. “Mastering the Tools: Natural Versus Artificial Vesicles in Nanomedicine.” Advanced Healthcare Materials 9, no. 18: e2000731.

[46]

Li, H., J. Sun, S. Xiao, L. Zhang, and D. Zhou. 2020. “Triterpenoid-Mediated Inhibition of Virus-Host Interaction: Is Now the Time for Discovering Viral Entry/Release Inhibitors From Nature?” Journal of Medicinal Chemistry 63, no. 24: 15371–15388.

[47]

Li, J., Y. Huang, W. Zhang, et al. 2023. “Insight into Binding Mechanism Between Three Whey Proteins and Mogroside V by Multi-Spectroscopic and Silico Methods: Impacts on Structure and Foaming Properties.” Food Hydrocolloids 135: 108207.

[48]

Li, L., J. Xie, Z. Zhang, et al. 2024. “Recent Advances in Medicinal and Edible Homologous Plant Polysaccharides: Preparation, Structure and Prevention and Treatment of Diabetes.” International Journal of Biological Macromolecules 258, Pt 2: 128873.

[49]

Li, S., S. Dong, W. Xu, et al. 2018. “Antibacterial Hydrogels.” Advanced Science 5, no. 5: 1700527.

[50]

Li, T., D. Cipolla, T. Rades, and B. J. Boyd. 2018. “Drug Nanocrystallisation Within Liposomes.” Journal of Controlled Release 288: 96–110.

[51]

Li, T., Y. Zhang, R. Dong, et al. 2024. “Identification and Mechanistic Exploration of Key Anti-Inflammatory Molecules in American Ginseng: Impacts on Signal Transducer and Activator of Transcription 3 STAT3 Phosphorylation and Macrophage Polarization.” Phytotherapy Research 38: 4307–4320.

[52]

Li, Y., Q.-X. Chang, P.-G. Xia, and Z.-S. Liang. 2024. “The Different Parts of Dendrobium Officinale Kimura et Migo: Traditional Uses, Phytochemistry, Pharmacological Activities, and Product Development Status and Potential.” Phytochemistry Reviews.

[53]

Li, Y., Z. Li, F. Zhang, et al. 2023. “Integrated Evolutionary Pattern Analyses Reveal Multiple Origins of Steroidal Saponins in Plants.” Plant Journal 116, no. 3: 823–839.

[54]

Li, Y., X. Liu, H. Liu, and L. Zhu. 2023. “Interfacial Adsorption Behavior and Interaction Mechanism in Saponin–Protein Composite Systems: A Review.” Food Hydrocolloids 136: 108295.

[55]

Li, Z., Y. Li, C. Liu, Y. Gu, and G. Han. 2024. “Research Progress of the Mechanisms and Applications of Ginsenosides in Promoting Bone Formation.” Phytomedicine 129: 155604.

[56]

Liao, Y., Z. Li, Q. Zhou, et al. 2021. “Saponin Surfactants Used in Drug Delivery Systems: A New Application for Natural Medicine Components.” International Journal of Pharmaceutics 603: 120709.

[57]

Liu, L., X. Li, Y. Zhu, et al. 2016. “Effect of Microencapsulation With Maillard Reaction Products of Whey Proteins and Isomaltooligosaccharide on the Survival of Lactobacillus rhamnosus.” Lwt 73: 37–43.

[58]

Liu, Y., L. Qu, S. Wan, Y. Li, and D. Fan. 2022. “Ginsenoside Rk1 Prevents UVB Irradiation-Mediated Oxidative Stress, Inflammatory Response, and Collagen Degradationviathe PI3K/AKT/NF-κB Pathway In Vitro and In Vivo.” Journal of Agricultural and Food Chemistry 70, no. 50: 15804–15817.

[59]

Liu, Z., Z. Li, H. Zhong, et al. 2017. “Recent Advances in the Environmental Applications of Biosurfactant Saponins: A Review.” Journal of Environmental Chemical Engineering 5, no. 6: 6030–6038.

[60]

Lobel, B. T., D. Baiocco, M. Al-Sharabi, A. F. Routh, Z. Zhang, and O. J. Cayre. 2024. “Current Challenges in Microcapsule Designs and Microencapsulation Processes: A Review.” ACS Applied Materials & Interfaces 16: 40326–40355.

[61]

J. M., P. H. Lin, Q. Yao, and C. Chen. 2010. “Chemical and Molecular Mechanisms of Antioxidants: Experimental Approaches and Model Systems.” Journal of Cellular and Molecular Medicine 14, no. 4: 840–860.

[62]

Lu, T., B. Li, D. Sun, M. Hu, J. Ma, and G. Sun. 2021. “Advances in Controlled Release of Microcapsules and Promising Applications in Self-Healing of Asphalt Materials.” Journal of Cleaner Production 294: 126270.

[63]

Luengo, G. S., A. L. Fameau, F. Léonforte, and A. J. Greaves. 2021. “Surface Science of Cosmetic Substrates, Cleansing Actives and Formulations.” Advances in Colloid and Interface Science 290: 102383.

[64]

Luo, J., M. Jia, X. Yang, Y. Chai, and Y. Bao. 2024. “Interaction Between Lactic Acid Bacteria and Polygonatum sibiricum Saponins and Its Application to Microencapsulated Co-Delivery.” Food Chemistry 448: 138959.

[65]

Luo, J., L. Jiang, B. Gao, Y. Chai, and Y. Bao. 2023. “Comprehensive in Silico Analysis of the Probiotics, and Preparation of Compound Probiotics-Polygonatum sibiricum Saponin With Hypoglycemic Properties.” Food Chemistry 404, Pt A: 134569.

[66]

Ma, L., C. Su, X. Li, et al. 2024. “Preparation and Characterization of Bilayered Microencapsulation for Co-Delivery Lactobacillus casei and Polyphenols via Zein-Chitosan Complex Coacervation.” Food Hydrocolloids 148: 109410.

[67]

Ma, X., W. Gao, M. I. Halawa, Y. Lan, J. Li, and G. Xu. 2019. “Lucigenin Fluorescent Assay of Tyrosinase Activity and Its Inhibitor Screening.” Sensors and Actuators B: Chemical 280: 41–45.

[68]

Majnooni, M. B., S. Fakhri, S. M. Ghanadian, et al. 2023. “Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways.” Metabolites 13, no. 3: 323.

[69]

Mathiyalagan, R., M. Murugesan, Z. M. Ramadhania, et al. 2024. “Triterpenoid Saponin-Based Supramolecular Host-Guest Injectable Hydrogels Inhibit the Growth of Melanoma via ROS-Mediated Apoptosis.” Materials Science and Engineering: R: Reports 160: 100824.

[70]

Meyer-Déru, L., G. David, and R. Auvergne. 2022. “Chitosan Chemistry Review for Living Organisms Encapsulation.” Carbohydrate Polymers 295: 119877.

[71]

Morris, S. A. V., G. B. Kasting, and K. P. Ananthapadmanabhan. 2022. “Surfactant Equilibria and Its Impact on Penetration Into Stratum Corneum.” Current Opinion in Colloid & Interface Science 59: 101579.

[72]

Murray, B. S. 2019. “Pickering Emulsions for Food and Drinks.” Current Opinion in Food Science 27: 57–63.

[73]

Orczyk, M., K. Wojciechowski, and G. Brezesinski. 2020. “The Influence of Steroidal and Triterpenoid Saponins on Monolayer Models of the Outer Leaflets of Human Erythrocytes, E. coli and S. cerevisiae Cell Membranes.” Journal of Colloid and Interface Science 563: 207–217.

[74]

Passos, F. R. S., H. G. Araújo-Filho, B. S. Monteiro, et al. 2022. “Anti-Inflammatory and Modulatory Effects of Steroidal Saponins and Sapogenins on Cytokines: A Review of Pre-Clinical Research.” Phytomedicine 96: 153842.

[75]

Peng, L., Y. Zhou, D. Y. Kong, and W. D. Zhang. 2010. “Antitumor Activities of Dammarane Triterpene Saponins From Bacopa monniera.” Phytotherapy Research 24, no. 6: 864–868.

[76]

Santini, E., E. Jarek, F. Ravera, L. Liggieri, P. Warszynski, and M. Krzan. 2019. “Surface Properties and Foamability of Saponin and Saponin-Chitosan Systems.” Colloids and Surfaces B: Biointerfaces 181: 198–206.

[77]

Schmid, C., A. Brockhoff, Y. B. Shoshan-Galeczki, et al. 2021. “Comprehensive Structure-Activity-Relationship Studies of Sensory Active Compounds in Licorice (Glycyrrhiza glabra).” Food Chemistry 364: 130420.

[78]

Schmitt, C., B. Grassl, G. Lespes, et al. 2014. “Saponins: A Renewable and Biodegradable Surfactant From Its Microwave-Assisted Extraction to the Synthesis of Monodisperse Lattices.” Biomacromolecules 15, no. 3: 856–862.

[79]

Schreiner, T. B., M. M. Dias, M. F. Barreiro, and S. P. Pinho. 2022. “Saponins as Natural Emulsifiers for Nanoemulsions.” Journal of Agricultural and Food Chemistry 70, no. 22: 6573–6590.

[80]

Serventi, L., and J. McNeill. 2024. “Upcycling Aquafaba and Liluva (Food Processing Wastewater of Legumes) Into New Value-Added Products.” Current Opinion in Food Science 58: 101197.

[81]

Shang, Y. F., H. Chen, Z. J. Ni, et al. 2024. “Platycodon Grandiflorum Saponins: Ionic Liquid-Ultrasound-Assisted Extraction, Antioxidant, Whitening, and Antiaging Activity.” Food Chemistry 451: 139521.

[82]

Sharkawy, A., M. F. Barreiro, and A. E. Rodrigues. 2020. “Chitosan-based Pickering Emulsions and Their Applications: A Review.” Carbohydrate Polymers 250: 116885.

[83]

Shen, C. Y., J. G. Jiang, L. Yang, D. W. Wang, and W. Zhu. 2017. “Anti-Ageing Active Ingredients From Herbs and Nutraceuticals Used in Traditional Chinese Medicine: Pharmacological Mechanisms and Implications for Drug Discovery.” British Journal of Pharmacology 174, no. 11: 1395–1425.

[84]

Sheth, T., S. Seshadri, T. Prileszky, and M. E. Helgeson. 2020. “Multiple Nanoemulsions.” Nature Reviews Materials 5, no. 3: 214–228.

[85]

Shin, K. C., and D. K. Oh. 2023. “Biotransformation of Platycosides, Saponins From Balloon Flower Root, into Bioactive Deglycosylated Platycosides.” Antioxidants 12, no. 2: 327.

[86]

Shu, G., N. Khalid, Z. Chen, M. A. Neves, C. J. Barrow, and M. Nakajima. 2018. “Formulation and Characterization of Astaxanthin-Enriched Nanoemulsions Stabilized Using Ginseng Saponins as Natural Emulsifiers.” Food Chemistry 255: 67–74.

[87]

da Silva Magedans, Y. V., M. A. Phillips, and A. G. Fett-Neto. 2020. “Production of Plant Bioactive Triterpenoid Saponins: From Metabolites to Genes and Back.” Phytochemistry Reviews 20, no. 2: 461–482.

[88]

Singh, B., J. P. Singh, N. Singh, and A. Kaur. 2017. “Saponins in Pulses and Their Health Promoting Activities: A Review.” Food Chemistry 233: 540–549.

[89]

Skopinska-Wisniewska, J., S. D. la Flor, and J. Kozlowska. 2021. “From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances.” International Journal of Molecular Sciences 22, no. 14: 7402.

[90]

Sobolewska, D., K. Michalska, I. Podolak, and K. Grabowska. 2016. “Steroidal Saponins From the Genus Allium.” Phytochemistry Reviews 15, no. 1: 1–35.

[91]

Song, P., Y. Zhang, G. Ma, Y. Zhang, A. Zhou, and J. Xie. 2017. “Gastrointestinal Absorption and Metabolic Dynamics of Jujuboside A, A Saponin Derived From the Seed of Ziziphus jujuba.” Journal of Agricultural and Food Chemistry 65, no. 38: 8331–8339.

[92]

Song, Z., Y. Huang, V. Prasad, et al. 2016. “Preparation of Surfactant-Resistant Polymersomes With Ultrathick Membranes Through RAFT Dispersion Polymerization.” ACS Applied Materials & Interfaces 8, no. 27: 17033–17037.

[93]

Stefanowicz-Hajduk, J., P. Graczyk, A. Hering, M. Gucwa, A. Nowak, and R. Hałasa. 2024. “An In Vitro Study on the Cytotoxic, Antioxidant, and Antimicrobial Properties of Yamogenin—A Plant Steroidal Saponin and Evaluation of Its Mechanism of Action in Gastric Cancer Cells.” International Journal of Molecular Sciences 25, no. 9: 4627.

[94]

Stern, D., and H. Cui. 2019. “Crafting Polymeric and Peptidic Hydrogels for Improved Wound Healing.” Advanced Healthcare Materials 8, no. 9: e1900104.

[95]

Sun, A., X. Xu, J. Lin, X. Cui, and R. Xu. 2015. “Neuroprotection by Saponins.” Phytotherapy Research 29, no. 2: 187–200.

[96]

Tanwar, B., R. Modgil, and A. Goyal. 2018. “Antinutritional Factors and Hypocholesterolemic Effect of Wild Apricot Kernel (Prunus armeniaca L.) as Affected by Detoxification.” Food & Function 9, no. 4: 2121–2135.

[97]

Timilsena, Y. P., A. Phosanam, and R. Stockmann. 2023. “Perspectives on Saponins: Food Functionality and Applications.” International Journal of Molecular Sciences 24, no. 17: 13538.

[98]

Tucker, I. M., A. Burley, R. E. Petkova, et al. 2020. “Surfactant/Biosurfactant Mixing: Adsorption of Saponin/Nonionic Surfactant Mixtures at the Air-Water Interface.” Journal of Colloid and Interface Science 574: 385–392.

[99]

Wan, Z., H. Xia, S. Guo, and C. Zeng. 2021. “Water-in-oil Pickering Emulsions Stabilized Solely by a Naturally Occurring Steroidal Sapogenin: Diosgenin.” Food Research International 147: 110573.

[100]

Wang, F. C., P. L. Hudson, K. Burk, and A. G. Marangoni. 2022. “Encapsulation of Cycloastragenol in Phospholipid Vesicles Enhances Transport and Delivery Across the Skin Barrier.” Journal of Colloid and Interface Science 608, Pt 2: 1222–1228.

[101]

Wang, L., X. Yang, X. Yu, Y. Yao, and G. Ren. 2013. “Evaluation of Antibacterial and Anti-Inflammatory Activities of Less Polar Ginsenosides Produced From Polar Ginsenosides by Heat-Transformation.” Journal of Agricultural and Food Chemistry 61, no. 50: 12274–12282.

[102]

Wang, L., X. Zhu, H. Liu, and B. Sun. 2024. “Medicine and Food Homology Substances: A Review of Bioactive Ingredients, Pharmacological Effects and Applications.” Food Chemistry 463, Pt 1: 141111.

[103]

Wang, P., J. Li, F. A. K. Attia, et al. 2019. “A Critical Review on Chemical Constituents and Pharmacological Effects of Lilium.” Food Science and Human Wellness 8, no. 4: 330–336.

[104]

Wang, Q., H. Chang, P. Deng, et al. 2023. “Investigation on the Simultaneous Inhibition of Advanced Glycation End Products, 4-Methylimidazole and Hydroxymethylfurfural in Thermal Reaction Meat Flavorings by Liquiritigenin, Liquiritin and Glycyrrhizic Acid and Possible Pathways.” Food Research International 173, Pt 2: 113414.

[105]

Wang, W., Z. Zeng, L. Xiang, et al. 2021. “Injectable Self-Healing Hydrogel via Biological Environment-Adaptive Supramolecular Assembly for Gastric Perforation Healing.” ACS Nano 15, no. 6: 9913–9923.

[106]

Wijesekara, T., J. Luo, and B. Xu. 2024. “Critical Review on Anti-Inflammation Effects of Saponins and Their Molecular Mechanisms.” Phytotherapy Research 38, no. 4: 2007–2022.

[107]

Wu, T., J. Cheng, J. Zhang, et al. 2022. “Hypoglycemic Activity of Self-Assembled Gellan Gum-Soybean Isolate Composite Hydrogel-Embedded Active Substance-Saponin.” Foods 11, no. 22: 3729.

[108]

Wu, Y., Z. Duan, L. Qu, Y. Zhang, C. Zhu, and D. Fan. 2023. “Gastroprotective Effects of Ginsenoside Rh4 Against Ethanol-Induced Gastric Mucosal Injury by Inhibiting the MAPK/NF-κB Signaling Pathway.” Food & Function 14, no. 11: 5167–5181.

[109]

Xia, X., J. Tao, Z. Ji, C. Long, Y. Hu, and Z. Zhao. 2020. “Increased Antitumor Efficacy of Ginsenoside Rh(2) via Mixed Micelles: In Vivo and In Vitro Evaluation.” Drug Delivery 27, no. 1: 1369–1377.

[110]

Xiang, X., K. Chen, A. Li, G. Yang, X. An, and J. Kan. 2024. “Decoding the Bitter Taste of Idesia polycarpa var. vestita Diels Fruit: Bitterness Contribution and Mechanisms.” Food Chemistry 460, Pt 2: 140609.

[111]

Xie, J. T., S. R. Mehendale, A. Wang, A. H. Han, J. A. Wu, J. Osinski, and C. S. Yuan. 2004. “American Ginseng Leaf: Ginsenoside Analysis and Hypoglycemic Activity.” Pharmacological Research 49, no. 2: 113–117.

[112]

Xie, J. J., J. Chen, S. K. Guo, et al. 2018. “Panax quinquefolium Saponin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis and the Associated Inflammatory Response Associated in Chondrocytes and Attenuates the Progression Of Osteoarthritis in Rat.” Biomedicine & Pharmacotherapy 97: 886–894.

[113]

Xie, T., and B. D. Vogt. 2020. “A Virtual Special Issue on Self-Healing Materials.” ACS Applied Materials & Interfaces 12, no. 44: 49277–49280.

[114]

Xue, P., X. Yang, L. Zhao, et al. 2020. “Relationship Between Antimicrobial Activity and Amphipathic Structure of Ginsenosides.” Industrial Crops and Products 143: 111929.

[115]

Xue, Z., Z. Cao, M. Jin, et al. 2021. “New Steroid Saponins From Dioscorea zingiberensis Yam and Their Medicinal Use Against I/R via an Anti-Inflammatory Effect.” Food & Function 12, no. 18: 8314–8325.

[116]

Yang, Y., L. Xu, J. Wang, et al. 2022. “Recent Advances in Polysaccharide-Based Self-Healing Hydrogels for Biomedical Applications.” Carbohydrate Polymers 283: 119161.

[117]

Yates, P. S., J. Roberson, L. K. Ramsue, and B.-H. Song. 2021. “Bridging the Gaps Between Plant and Human Health: A Systematic Review of Soyasaponins.” Journal of Agricultural and Food Chemistry 69, no. 48: 14387–14401.

[118]

Ye, S., L. Zhao, Y. Qi, et al. 2023. “Identification of Azukisapogenol Triterpenoid Saponins From Oxytropis hirta Bunge and Their Aphicidal Activities against Pea Aphid Acyrthosiphon pisum Harris.” Pest Management Science 79, no. 1: 55–67.

[119]

Yi, Y., J. Li, X. Lai, et al. 2022. “Natural Triterpenoids From Licorice Potently Inhibit SARS-CoV-2 Infection.” Journal of Advanced Research 36: 201–210.

[120]

Yu, W., Y. Wang, D. Jiang, et al. 2022. “A Saponin From Astragalus Promotes Pancreatic Ductal Organoids Differentiation Into Insulin-Producing Cells.” Phytomedicine 102: 154190.

[121]

Zhang, Y., X. Zhong, Z. Xi, Y. Li, and H. Xu. 2023. “Antiviral Potential of the Genus Panax: An Updated Review on Their Effects and Underlying Mechanism of Action.” Journal of Ginseng Research 47, no. 2: 183–192.

[122]

Zhang, Z., X. Zhao, M. Gao, et al. 2022. “Dioscin Alleviates Myocardial Infarction Injury via Regulating BMP4/NOX1-Mediated Oxidative Stress and Inflammation.” Phytomedicine 103: 154222.

[123]

Zhong, Y., J. Liu, D. Sun, et al. 2022. “Dioscin Relieves Diabetic Nephropathy via Suppressing Oxidative Stress and Apoptosis, and Improving Mitochondrial Quality and Quantity Control.” Food & Function 13, no. 6: 3660–3673.

[124]

Zhou, T., G. Wang, F. Zhen, et al. 2024. “Study on Efficient Extraction of Saponins From Polygonatum sibiricum by Enzyme Assisted Cold Isostatic Pressing Technology.” Industrial Crops and Products 220: 119163.

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2024 The Author(s). Food Bioengineering published by John Wiley & Sons Australia, Ltd. on behalf of State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology.

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