A Review of CD4+ T Cell-mediated Immune Drift and Mechanisms in the Treatment of Immune Inflammatory Skin Diseases with Biological Agents
Fangyuan Miao , Chen Luo , Jinfeng Chen , Changjie Shang , Zechao Zhang , Liuyun Yang , Min Zhu
›› 2025, Vol. 4 ›› Issue (2) : 128 -134.
A Review of CD4+ T Cell-mediated Immune Drift and Mechanisms in the Treatment of Immune Inflammatory Skin Diseases with Biological Agents
Immunoinflammatory skin diseases are characterized by an imbalance in immune homeostasis, and their chronic inflammatory processes involve a complex regulatory network of CD4+ T cell differentiation. With the widespread use of biologics (e.g., interleukin-17/interleukin-23 inhibitors) in psoriasis, atopic dermatitis, and other diseases, the adverse effects triggered by the phenomenon of CD4+ T cell-mediated immune drift have attracted significant attention, with the skin being the primary target as an immune organ. In this paper, we provide a review of the clinical features of the skin and the mechanisms of immune drift caused by different types of biologics, as well as the therapeutic modalities.
Adverse reactions / Biological agents / Immune drift / Skin / CD4+ T cells / IL-17 inhibitors / IL-12/23 inhibitors / IL-4/13 inhibitors / PD-1/PD-L1 inhibitors / TNF-α inhibitors
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