Licochalcone B: A New Drug for the Prevention and Treatment of Radiation Damage

Acknowledgement

None.

Funding

This study was funded by the Yangtze University Science and Technology Aid to Tibet Medical Talent Training Program Project (2023YZ13 to XCP), the National Innovation and Entrepreneurship Training Program for College Students (202310489021 to XCP), the Graduate Innovation Fund of the Health Science Center, Yangtze University (202303 to XCP), and the Wujieping Medical Foundation - Digestive Tract Cancer Research Fund (320.6750.2024-10-3 to XCP).

Conflict of interest

XCP has been an editorial board member of Future Integrative Medicine since November 2021. The other authors have no con-flicts of interest related to this publication.

Author contributions

Study concept and design (JQW, XCP), funding acquisition (XCP), drafting of the manuscript (JQW, XCP), critical revision of the manuscript for important intellectual content (JQW, TTL, WXL, XCP), and study supervision (XCP). All authors have made significant contributions to this study and have approved the final manuscript.

References

[1] Helm JS, Rudel RA. Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hor-monal regulation of the breast. Arch Toxicol 2020; 94(5):1511-1549. doi:10.1007/s00204-020-02752-z,PMID:32399610.

[2] Gale RP. Radiation and leukaemia: Which leukaemias and what doses? Blood Rev 2023;58:101017. doi:10.1016/j.blre.2022.101017,PMID:36220737.

[3] Altomare A, Fiore M, D’Ercole G, Imperia E, Nicolosi RM, Della Posta S, et al. Protective Role of Natural Compounds under Radiation-In-duced Injury. Nutrients 2022; 14(24):5374. doi:10.3390/nu14245374,PMID:36558533.

[4] Yu YX, Tian HQ. Research progress on clinical application of radiation protection agents. Shandong Medical Journal 2022; 62(1):111-114. doi:10.3969/j.issn.1002-266X.2022.01.027.

[5] Hosseinimehr SJ. Trends in the development of radioprotective agents. Drug Discov Today 2007; 12(19-20):794-805. doi:10.1016/j.drudis.2007.07.017, PMID:17933679.

[6] Shaikh S, Lee EJ, Ahmad K, Choi I. Therapeutic potential and ac-tion mechanisms of licochalcone B: a mini review. Front Mol Biosci 2024;11:1440132. doi:10.3389/fmolb.2024.1440132,PMID:39021879.

[7] Ren B, Jin J, Wang Y, Xu X, Liu Y, Ding H, et al. Radioprotective Effects of Licochalcone B: DNA Protection, Cytokine Inhibition, and Antioxidant Boost. Future Integr Med 2024; 3(4):239-250. doi:10.14218/FIM.2024.00031.

[8] Dipalma G, Inchingolo AM, Latini G, Ferrante L, Nardelli P, Malcangi G, et al. The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic Review. An-tioxidants (Basel) 2024; 13(10):1160. doi:10.3390/antiox13101160,PMID:39456414.

[9] Jin Y, Liu X, Liang X, Liu J, Liu J, Han Z, et al. Resveratrol rescues cutane-ous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis. Cell Death Dis 2023; 13(10):847. doi:10.1038/s41419-022-05281-y,PMID:36587031.

[10] Wang SW, Ren BX, Qian F, Luo XZ, Tang X, Peng XC, et al. Radioprotec-tive effect of epimedium on neurogenesis and cognition after acute radiation exposure. Neurosci Res 2019; 145:46-53. doi:10.1016/j.neures.2018.08.011, PMID:30145270.

[11] Yin G, Wang Q, Lv T, Liu Y, Peng X, Zeng X, et al. The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure. Curr Radiopharm 2024; 17(3):257-265. doi:10.2174/0118744710274008231220055033,PMID:38204264.

[12] Lin H, Su M, Wen C, Tang Y, Li H, Wu Y, et al. Chalcones from plants cause toxicity by inhibiting human and rat 11β-hydroxysteroid dehydrogenase 2: 3D-quantitative structure-activity relation-ship (3D-QSAR) and in silico docking analysis. Food Chem Toxicol 2024;184:114415. doi:10.1016/j.fct.2023.114415,PMID:38141941.

[13] Hosseinimehr SJ, Zakaryaee V, Ahmadi A, Akhlaghpoor S. Radioprotec-tive effects of chlorogenic acid against mortality induced by gamma-irradiation in mice. Methods Find Exp Clin Pharmacol 2008; 30(1):13-16. doi:10.1358/mf.2008.30.1.1134339,PMID:18389093.