Background and objectives Several studies have suggested that rose hip extracts have anti-obesity potential. Conventional medicines treating obesity are followed by multiple adverse side effects and is very cost full to society. This makes the investigation of herbal remedies with anti-obesity effects potential highly relevant. This systematic review aims to shed light on the results of existing literature reports on the correlation between the intake of rose hip extracts and anti-obesity effects.
Methods A systematic literature search of PubMed and Web of Science was made to localize relevant experimental literature. Nine articles met the inclusion criteria, including one in vitro study, seven in vivo animal studies, and one human trial with pre-obese subjects. All nine articles are objectively reviewed in this systematic review.
Results Eight out of nine articles, including the article on humans, presented significant anti-obesity effects. Though some limitations of the studies were found, including the human trial, seven possible metabolic mechanisms are suggested as the underlying cause of the significant effects.
Conclusions Based on the findings of this review, rose hip extracts containing tiliroside found in the seeds have the potential to become a new herbal remedy with anti-obesity effects. Nevertheless, more research is needed to assess the effectiveness and optimal dosage of the rose hip treatment and to elucidate the underlying mechanisms of the effects.
Acknowledgments
The authors acknowledge Mahsa Jalili for valuable input.
Funding
The authors declare that no funding was received to conduct this review.
Conflict of interest
The authors have no conflicts of interest to declare.
Author contributions
ISBP was the main author of this paper. KW wrote the parts con-cerning the physical mechanisms and was deeply involved in writ-ing of the discussion.
Data sharing statement
All data extracted from the included studies can be found in within this article.
| [1] |
Abdi Beshir S, Ahmed Elnour A, Soorya A, Parveen Mohamed A, Sir Loon Goh S, Hussain N, et al. A narrative review of approved and emerg-ing anti-obesity medications. Saudi Pharm J 2023; 31(10):101757. doi:10.1016/j.jsps.2023.101757,PMID:37712012.
|
| [2] |
Suran M. As Ozempic’s Popularity Soars, Here’s What to Know About Semaglutide and Weight Loss. JAMA 2023; 329(19):1627-1629. doi:10.1001/jama.2023.2438,PMID:37099334.
|
| [3] |
Conforti F, Pan MH. Natural Products in Anti-Obesity Therapy. Mol-ecules 2016; 21(12):1750. doi:10.3390/molecules21121750,PMID:27999406.
|
| [4] |
Goto T, Teraminami A, Lee JY, Ohyama K, Funakoshi K, Kim YI, et al. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal mus-cle in obese-diabetic mice. J Nutr Biochem 2012; 23(7):768-776. doi:10.1016/j.jnutbio.2011.04.001,PMID:21889885.
|
| [5] |
Lustrup DC, Winther K. In: Kumar S (ed). Rose Hip as a Nutraceutical. Medicinal Plants. London: IntechOpen; 2022:395-420. doi:10.5772/intechopen.105392.
|
| [6] |
Winther K, Vinther Hansen AS, Campbell-Tofte J. Bioactive ingredi-ents of rose hips (Rosa canina L) with special reference to antioxi-dative and anti-inflammatory properties: in vitro studies. Botanics 2016; 6:11-23. doi:10.2147/btat.s91385.
|
| [7] |
Ninomiya K, Matsuda H, Kubo M, Morikawa T, Nishida N, Yoshikawa M. Potent anti-obese principle from Rosa canina: structural require-ments and mode of action of trans-tiliroside. Bioorg Med Chem Lett 2007; 17(11):3059-3064. doi:10.1016/j.bmcl.2007.03.051,PMID:17400451.
|
| [8] |
Guillemet D, Belles C, Gomes A, Azalbert V, André M, Faresse N, et al. Screening for anti-adipogenic, pro-lipolytic and thermogenic plant extracts by models associating intestinal epithelial cells with human adipose cells. Eur J Nutr 2022; 61(4):2201-2215. doi:10.1007/s00394-021-02794-8,PMID:35092460.
|
| [9] |
Nagatomo A, Nishida N, Matsuura Y, Shibata N. Rosehip Extract Inhib-its Lipid Accumulation in White Adipose Tissue by Suppressing the Ex-pression of Peroxisome Proliferator-activated Receptor Gamma. Prev Nutr Food Sci 2013; 18(2):85-91. doi:10.3746/pnf.2013.18.2.085,PMID:24471115.
|
| [10] |
Shen CY, Hao YF, Hao ZX, Liu Q, Zhang L, Jiang CP, et al. Flavonoids from Rosa davurica Pall. fruits prevent high-fat diet-induced obe-sity and liver injury via modulation of the gut microbiota in mice. Food Funct 2021; 12(20):10097-10106. doi:10.1039/d1fo01373d,PMID:34522931.
|
| [11] |
Cavalera M, Axling U, Berger K, Holm C. Rose hip supplementation in-creases energy expenditure and induces browning of white adipose tissue. Nutr Metab (Lond) 2016; 13:91. doi:10.1186/s12986-016-0151-5,PMID:27980600.
|
| [12] |
Taherzadeh S, Rasoulian B, Khaleghi M, Rashidipour M, Mogharnasi M, Kaeidi A. Anti-obesity effects of aerobic exercise along with Rosa canina seed extract supplementation in rats: The role of irisin and adipolin. Obes Res Clin Pract 2023; 17(3):218-225. doi:10.1016/j.orcp.2023.04.006, PMID:37169705.
|
| [13] |
Andersson U, Henriksson E, Ström K, Alenfall J, Göransson O, Holm C. Rose hip exerts antidiabetic effects via a mechanism involving down-regulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab 2011; 300(1):E111-E121. doi:10.1152/ajpendo.00268.2010, PMID:20959531.
|
| [14] |
Nagatomo A, Nishida N, Fukuhara I, Noro A, Kozai Y, Sato H, et al. Dai-ly intake of rosehip extract decreases abdominal visceral fat in pre-obese subjects: a randomized, double-blind, placebo-controlled clin-ical trial. Diabetes Metab Syndr Obes 2015; 8:147-156. doi:10.2147/DMSO.S78623,PMID:25834460.
|
| [15] |
Marstrand K, Campbell-Tofte J. The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation - part II animal and human studies. Botanics 2016; 6:59-73. doi:10.2147/btat.s55573.
|
| [16] |
Rein E, Kharazmi A, Winther K. A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis - A double-blind, placebo-controlled, randomised trial. Phytomedicine 2004; 11(5):383-391. doi:10.1016/j.phymed.2004.01.001.
|
| [17] |
Tayyaba, Siddiqui T, Doultani PR. Tirzepatide (Mounjaro) - a novel Pharmacotherapeutic Agent for Obesity. J Pak Med Assoc 2023; 73(5):1171. doi:10.47391/JPMA.7685,PMID:37218275.
|
| [18] |
Lobstein T, Jackson-Leach R, Powis J, Brinsden H, Gray M. World Obesity Atlas 2023. Accessed December 15, 2023.
|
| [19] |
Grochowski DM, Locatelli M, Granica S, Cacciagrano F, Tomczyk M. A Review on the Dietary Flavonoid Tiliroside. Compr Rev Food Sci Food Saf 2018; 17(5):1395-1421. doi:10.1111/1541-4337.12389,PMID:33350157.
|
| [20] |
Wójciak W, Żuk M, Sowa I, Mazurek B, Tyśkiewicz K, Wójciak M. Re-covery of Bioactive Components from Strawberry Seeds Residues Post Oil Extraction and Their Cosmetic Potential. Applied Sciences 2024; 14(2):783. doi:10.3390/app14020783.
|
PDF
