Exploring the Molecular Mechanisms and Therapeutic Potentials of Essential Oils: A Systems Biology

Rakesh Kashyap

›› 2024, Vol. 3 ›› Issue (2) : 116 -131.

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›› 2024, Vol. 3 ›› Issue (2) :116 -131. DOI: 10.14218/FIM.2023.00071
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Exploring the Molecular Mechanisms and Therapeutic Potentials of Essential Oils: A Systems Biology
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Abstract

Essential oils, known for their pleasant aromas, not only calm the mind and elevate the mood but also captivate the interest of researchers aiming to unveil their vast potential. Various methodologies are employed to explore the diverse capabilities of essential oils, often yielding promising and significant outcomes. This review aims to elucidate the molecular mechanisms of essential oils at the cellular level. It identifies multiple mechanisms through which essential oils exhibit their therapeutic effects across various systems. However, a comprehensive understanding of their fundamental mechanisms still necessitates extensive research. In this review, we discuss the mechanisms underlying the biological activities of essential oils, specifically their antioxidant, antimicrobial, anticarcinogenic, anti-diabetic, and anti-inflammatory properties.

Keywords

Essential oil / Antioxidant / Antimicrobial / Anticarcinogenic / Anti-diabet-ic / Anti-inflammatory

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Rakesh Kashyap. Exploring the Molecular Mechanisms and Therapeutic Potentials of Essential Oils: A Systems Biology. , 2024, 3(2): 116-131 DOI:10.14218/FIM.2023.00071

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The author has no conflict of interest related to this publication.

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RK is the sole author of the manuscript.

References

[1]

Kar S, Gupta P, Gupta J. Essential oils: biological activity beyond aro-matherapy. Nat Prod Sci 2018; 24(3):139-147. doi:10.20307/nps.2018.24.3.139.

[2]

Figueiredo AC. Biological properties of essential oils and volatiles: Sources of variability. Nat Volatiles & Essent Oils 2017; 4(4):1-13.

[3]

Zhang Y, Tang J, Liu Q, Ge J, Ma Z, Mou J, et al. Biological, func-tional and network pharmacological exploration of essential oils in treatment and healthcare of human diseases. Future Integr Med 2023; 2(1):23-31. doi:10.14218/FIM.2022.00038.

[4]

Zukowska G, Durczynska Z. Properties and applications of essential oils: a review. JEE 2024; 25(2):333-340. doi:10.12911/22998993/177404.

[5]

Tavassoly I, Goldfarb J, Iyengar R. Systems biology primer: the ba-sic methods and approaches. Essays Biochem 2018; 62(4):487-500. doi:10.1042/EBC20180003,PMID:30287586.

[6]

Tkacik G, Bialek W. Cell biology:networks, regulation and pathways. In: Meyers RC ed. Encyclopedia of complexity and systems science. New York: Springer; 2009:719-741. doi:10.1007/978-0-387-30440-3_48.

[7]

Mast FD, Ratushny AV, Aitchison JD. Systems cell biology. J Cell Biol 2014; 206(6):695-706. doi:10.1083/jcb.201405027,PMID:25225336.

[8]

Pandey AK, Kumar P, Singh P, Tripathi NN, Bajpai VK. Essential Oils: Sources of Antimicrobials and Food Preservatives. Front Microbiol 2016; 7:2161. doi:10.3389/fmicb.2016.02161,PMID:28138324.

[9]

Hyldgaard M, Mygind T, Meyer RL. Essential oils in food preservation: mode of action, synergies, and interactions with food matrix com-ponents. Front Microbiol 2012;3:12. doi:10.3389/fmicb.2012.00012,PMID:22291693.

[10]

Su LJ, Zhang JH, Gomez H, Murugan R, Hong X, Xu D, et al. Reac-tive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Au-tophagy, and Ferroptosis. Oxid Med Cell Longev 2019; 2019:5080843. doi:10.1155/2019/5080843,PMID:31737171.

[11]

Harayama T, Riezman H. Understanding the diversity of membrane lipid composition. Nat Rev Mol Cell Biol 2018; 19(5):281-296. doi:10.1038/nrm.2017.138,PMID:29410529.

[12]

Li Y, Si D, Sabier M, Liu J, Si J, Zhang X. Guideline for screening an-tioxidant against lipid-peroxidation by spectrophotometer. eFood 2023; 4(4):e80. doi:10.1002/efd2.80.

[13]

Ramana KV, Srivastava S, Singhal SS. Lipid peroxidation prod-ucts in human health and disease 2014. Oxid Med Cell Longev 2014; 2014:162414. doi:10.1155/2014/162414,PMID:25302089.

[14]

Manjamalai A, Berlin Grace VM. Antioxidant activity of essential oils from Wedelia chinensis (Osbeck) in vitro and in vivo lung cancer bearing C57BL/6 mice. Asian Pac J Cancer Prev 2012; 13(7):3065-3071. doi:10.7314/apjcp.2012.13.7.3065,PMID:22994711.

[15]

Dontha S. A review on antioxidant methods. Asian J Pharm Clin Res 2016; 9(8):14-32. doi:10.22159/ajpcr.2016.v9s2.13092.

[16]

Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, Lele RD. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India 2004; 52:794-804. PMID:15909857.

[17]

Mohamed AA, Alotaibi BM. Essential oils of some medicinal plants and their biological activities: A mini review. J Umm Al-Qura Univ Appl Sci 2023; 9:40-49. doi:10.1007/s43994-022-00018-1.

[18]

Kebede BH, Forsido SF, Tola YB, Astatkie T. Free radical scaveng-ing capacity, antibacterial activity and essential oil composition of turmeric (Curcuma domestica) varieties grown in Ethiopia. Heli-yon 2021; 7(2):e06239. doi:10.1016/j.heliyon.2021.e06239,PMID:33659752.

[19]

Foti MC, Ingold KU. Mechanism of inhibition of lipid peroxidation by gamma-terpinene, an unusual and potentially useful hydrocarbon antioxidant. J Agric Food Chem 2003; 51(9):2758-2765. doi:10.1021/jf020993f,PMID:12696969.

[20]

de Sousa DP, Damasceno ROS, Amorati R, Elshabrawy HA, de Cas-tro RD, Bezerra DP, et al. Essential Oils: Chemistry and Pharmaco-logical Activities. Biomolecules 2023; 13(7):1144. doi:10.3390/biom13071144,PMID:37509180.

[21]

Sultan MT, Butt MS, Karim R, Ahmed W, Kaka U, Ahmad S, et al. Nigella sativa fixed and essential oil modulates glutathione redox enzymes in potassium bromate induced oxidative stress. BMC Com-plement Altern Med 2015; 15:330. doi:10.1186/s12906-015-0853-7,PMID:26385559.

[22]

El Hachlafi N, Fikri-Benbrahim K, Al-Mijalli SH, Elbouzidi A, Jeddi M, Abdallah EM, et al. Tetraclinis articulata (Vahl) Mast. essential oil as a promising source of bioactive compounds with antimicrobial, antiox-idant, anti-inflammatory and dermatoprotective properties: In vitro and in silico evidence. Heliyon 2024; 10(1):e23084. doi:10.1016/j.heliyon.2023.e23084, PMID:38169772.

[23]

Riberio B. Glutathione: the master antioxidant. Ozone Ther Glob J 2023; 13(1):175-197.

[24]

Ridaoui K, Guenaou I, Taouam I, Cherki M, Bourhim N, Elamrani A, et al. Comparative study of the antioxidant activity of the essential oils of five plants against the H(2)O(2) induced stress in Saccharomy-ces cerevisiae. Saudi J Biol Sci 2022; 29(3):1842-1852. doi:10.1016/j.sjbs.2021.10.040, PMID:35280527.

[25]

Rosa AC, Corsi D, Cavi N, Bruni N, Dosio F. Superoxide Dismutase Administration: A Review of Proposed Human Uses. Molecules 2021; 26(7):1844. doi:10.3390/molecules26071844,PMID:33805942.

[26]

Trist BG, Hilton JB, Hare DJ, Crouch PJ, Double KL. Superoxide Dis-mutase 1 in Health and Disease: How a Frontline Antioxidant Be-comes Neurotoxic. Angew Chem Int Ed Engl 2021; 60(17):9215-9246. doi:10.1002/anie.202000451,PMID:32144830.

[27]

Fujii J, Homma T, Osaki T. Superoxide Radicals in the Execution of Cell Death. Antioxidants (Basel) 2022; 11(3):501. doi:10.3390/an-tiox11030501,PMID:35326151.

[28]

Ighodaro OM, Akinloye OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alex-andria J Med 2018; 54(4):287-293. doi:10.1016/j.ajme.2017.09.001.

[29]

Fukai T, Ushio-Fukai M. Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 2011; 15(6):1583-1606. doi:10.1089/ars.2011.3999,PMID:21473702.

[30]

Gayashani Sandamalika WM, Kwon H, Lim C, Yang H, Lee J. The possi-ble role of catalase in innate immunity and diminution of cellular oxi-dative stress: Insights into its molecular characteristics, antioxidant activity, DNA protection, and transcriptional regulation in response to immune stimuli in yellowtail clownfish (Amphiprion clarkii). Fish Shellfish Immunol 2021; 113:106-117. doi:10.1016/j.fsi.2021.03.022,PMID:33826938.

[31]

Nandi A, Yan LJ, Jana CK, Das N. Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases. Oxid Med Cell Longev 2019; 2019:9613090. doi:10.1155/2019/9613090,PMID:31827713.

[32]

Goyal MM, Basak A. Human catalase: looking for complete identity. Protein Cell 2010; 1(10):888-897. doi:10.1007/s13238-010-0113-z,PMID:21204015.

[33]

Alfonso-Prieto M, Biarnés X, Vidossich P, Rovira C. The molecular mech-anism of the catalase reaction. J Am Chem Soc 2009; 131(33):11751-11761. doi:10.1021/ja9018572,PMID:19653683.

[34]

Król M, Kepinska M. Human Nitric Oxide Synthase-Its Functions, Polymorphisms, and Inhibitors in the Context of Inflammation, Diabetes and Cardiovascular Diseases. Int J Mol Sci 2020; 22(1):56. doi:10.3390/ijms22010056,PMID:33374571.

[35]

Carlstrom M, Montenegro MF. Therapeutic value of stimulating the nitrate-nitrite-nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease. J Intern Med 2019; 285(1):2-18. doi:10.1111/joim.12818,PMID:30039620.

[36]

Lundberg JO, Weitzberg E. Nitric oxide signaling in health and dis-ease. Cell 2022; 185(16):2853-2878. doi:10.1016/j.cell.2022.06.010,PMID:35931019.

[37]

Papi S, Ahmadizar F, Hasanvand A. The role of nitric oxide in inflam-mation and oxidative stress. Immunopathol Persa 2019; 5(1):e08. doi:10.15171/ipp.2019.08.

[38]

Lubos E, Handy DE, Loscalzo J. Role of oxidative stress and ni-tric oxide in atherothrombosis. Front Biosci 2008; 13:5323-5344. doi:10.2741/3084,PMID:18508590.

[39]

Sohilait HJ, Kainama H. Free Radical Scavenging Activity of Essential Oil of Eugenia caryophylata from Amboina Island and Derivatives of Eugenol. Open Chem 2019; 17(1):422-428. doi:10.1515/chem-2019-0047.

[40]

da Costa LS, Cruz JN, Mali SN, Almeida LQ, do Nasci-mento LD, et al. First Report on the Chemical Composition, Antioxi-dant Capacity, and Preliminary Toxicity to Artemia salina L. of Croton campinarensis Secco, A. Rosário & PE Berry (Euphorbiaceae) Essen-tial Oil, and In Silico Study. Antioxidants (Basel) 2022; 11(12):2410. doi:10.3390/antiox11122410,PMID:36552618.

[41]

Dadashpour M, Rasooli I, Sefidkon F, Rezaei MB, Astaneh DAS. Lipid peroxidation inhibition, superoxide anion and nitric oxide radical scavenging properties of Thymus daenensis and Anethum graveo-lens essential oils. J Med Plant Res 2011; 10(37):109-120.

[42]

Tit DM, Bungau SG. Antioxidant Activity of Essential Oils. Antioxi-dants (Basel) 2023; 12(2):383. doi:10.3390/antiox12020383,PMID:36829942.

[43]

Goze I, Alim A, Tepe AS, Sokmen M, Sevgi K, Tepe B. Screening of the antioxidant activity of essential oil and various extracts of Origanum rotundifolium Boiss. from Turkey. J Med Plant Res 2009; 3(4):246-254.

[44]

Amiri H. Essential oils composition and antioxidant properties of three thymus species. Evid Based Complement Alternat Med 2012; 2012:728065. doi:10.1155/2012/728065,PMID:21876714.

[45]

Cioanca O, Mircea C, Hritcu L, Trifan A, Mihasan M, Aprotosoaie AC, et al. In vitro - in vivo correlation of the antioxidant capacity of Sal-viae aetheroleum essential oil. Farmacia 2015; 63(1):34-39.

[46]

Burits M, Bucar F. Antioxidant activity of Nigella sativa essen-tial oil. Phytother Res 2000;14(5):323-328. doi:10.1002/1099-1573(200008)14:5<323::aid-ptr621>3.0.co;2-q, PMID:10925395.

[47]

Farias PKL, Silva JCRL, Souza CND, Fonseca FSAD, Brandi IV, Martins ER, et al. Antioxidant activity of essential oils from condiment plants and their effect on lactic cultures and pathogenic bacteria. Cienc Ru-ral 2019; 49(2):1-12. doi:10.1590/0103-8478cr20180140.

[48]

Kumar V, Mathela CS, Kumar M, Tewari G. Antioxidant potential of essential oils from some Himalayan Asteraceae and Lamiace-ae species. Med Drug Discov 2019;1:100004. doi:10.1016/j.me-didd.2019.100004.

[49]

Rahman A, Afroj M, Islam R, Islam KD, Hossain MA, Na M. In vitro antioxidant potential of the essential oil and leaf extracts of Curcuma zedoaria Rosc. J Appl Pharm Sci 2014; 4(2):107-111. doi:10.7324/JAPS.2014.40217.

[50]

Inaam El, Sara H, Saadia L, Mohamed E, Abdesalam L. Study of an-tioxidant activity of essential oils extracted from Moroccan medici-nal and aromatic plants. European J Med Plants 2015; 10(2):1-12. doi:10.9734/EJMP/2015/19955.

[51]

Oluyele O, Oladunmoye MK, Ogundare AO. Antioxidant potential of essential oil from Phoenix dactylifera ( L.) seed. GSC Biol Pharm Sci 2022; 19(2):014-022. doi:10.30574/gscbps.2022.19.2.0139.

[52]

Ozkan A, Erdogan A, Sokmem M, Tugrulay S, Unal O. Antitumoral and antioxidant effect of essential oils and in vitro antioxidant properties of essential oils and aqueous extracts from Salvia pisidica. Biologia 2010; 65(6):990-996. doi:10.2478/s11756-010-0108-5.

[53]

Yap PSX, Yusoff K, Lim SHE, Chong CM, Lai KS. Membrane disrup-tion properties of essential oils-A double-edged sword? Processes 2021; 9(4):595. doi:10.3390/pr9040595.

[54]

Wu K, Lin Y, Chai X, Duan X, Zhao X, Chun C. Mechanisms of vapor-phase antibacterial action of essential oil from Cinnamomum cam-phora var. linaloofera Fujita against Escherichia coli. Food Sci Nutr 2019; 7(8):2546-2555. doi:10.1002/fsn3.1104,PMID:31428342.

[55]

Zhang J, Ye KP, Zhang X, Pan DD, Sun YY, Cao JX. Antibacterial Activ-ity and Mechanism of Action of Black Pepper Essential Oil on Meat-Borne Escherichia coli. Front Microbiol 2016; 7:2094. doi:10.3389/fmicb.2016.02094,PMID:28101081.

[56]

Yuan C, Hao X. Antibacterial mechanism of action and in silico molec-ular docking studies of Cupressus funebris essential oil against drug resistant bacterial strains. Heliyon 2023; 9(8):e18742. doi:10.1016/j.heliyon.2023.e18742, PMID:37636470.

[57]

Dias C, Nylandsted J. Plasma membrane integrity in health and dis-ease: significance and therapeutic potential. Cell Discov 2021; 7(1):4. doi:10.1038/s41421-020-00233-2,PMID:33462191.

[58]

McCarthy JV, Cotter TG. Cell shrinkage and apoptosis: a role for po-tassium and sodium ion efflux. Cell Death Differ 1997; 4(8):756-770. doi:10.1038/sj.cdd.4400296,PMID:16465288.

[59]

Bortner CD, Hughes FM Jr, Cidlowski JA. A primary role for K+ and Na+ efflux in the activation of apoptosis. J Biol Chem 1997; 272(51):32436-42. doi:10.1074/jbc.272.51.32436, PMID:9405453.

[60]

Owen L, White AW, Laird K. Characterisation and screening of antimi-crobial essential oil components against clinically important antibi-otic-resistant bacteria using thin layer chromatography-direct bioau-tography hyphenated with GC-MS, LC-MS and NMR. Phytochem Anal 2019; 30(2):121-131. doi:10.1002/pca.2797,PMID:30280447.

[61]

Bouyahya A, Abrini J, Dakka N, Bakri Y. Essential oils of Origanum compactum increase membrane permeability, disturb cell mem-brane integrity, and suppress quorum-sensing phenotype in bacteria. J Pharm Anal 2019; 9(5):301-311. doi:10.1016/j.jpha.2019.03.001,PMID:31929939.

[62]

Mangalagiri NP, Velagapudi K, Panditi SK, Jeevigunta NLL. Mechanism of action of essential oils and their major components. Research & Reviews: J Bot 2021; 10(3):33-43. doi:10.37591/RRJoB.

[63]

Yang XN, Khan I, Kang SC. Chemical composition, mechanism of an-tibacterial action and antioxidant activity of leaf essential oil of For-sythia koreana deciduous shrub. Asian Pac J Trop Med 2015; 8(9):694-700. doi:10.1016/j.apjtm.2015.07.031, PMID:26433652.

[64]

Issa D, Najjar A, Greige-Gerges H, Nehme H. Screening of Some Es-sential Oil Constituents as Potential Inhibitors of the ATP Synthase of Escherichia coli. J Food Sci 2019; 84(1):138-146. doi:10.1111/1750-3841.14421,PMID:30569590.

[65]

Chen Y, Zhao J, Liu C, Wu D, Wang X. In-vitro antibacterial activity and mechanism of Monarda didyma essential oils against Carbapenem-resistant Klebsiella pneumoniae. BMC Microbiol 2023; 23(1):263. doi:10.1186/s12866-023-03015-4,PMID:37730531.

[66]

Babaei G, Gholizadeh-Ghaleh Aziz S, Rajabi Bazl M, Khadem An-sari MH. A comprehensive review of anticancer mechanisms of ac-tion of Alantolactone. Biomed Pharmacother 2021;136:111231. doi:10.1016/j.biopha.2021.111231,PMID:33454597.

[67]

Amjad E, Sokouti B, Asnaashari S. A systematic review of anti-can-cer roles and mechanisms of kaempferol as a natural compound. Cancer Cell Int 2022; 22(1):260. doi:10.1186/s12935-022-02673-0,PMID:35986346.

[68]

Mohamed Abdoul-Latif F, Ainane A, Houmed Aboubaker I, Moham-ed J, Ainane T. Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy. Pharmaceuticals (Basel) 2023; 16(8):1086. doi:10.3390/ph16081086,PMID:37631000.

[69]

Zishan M, Saidurrahman S, Azeemuddin A, Ahmad Z, Hussain MW. Natural products used as anti-cancer agents. J Drug Deliv Ther 2017; 7(3):11-18. doi:10.22270/jddt.v7i3.1443.

[70]

Ramel C, Alekperov UK, Ames BN, Kada T, Wattenberg LW. Inter-national Commission for Protection Against Environmental Mu-tagens and Carcinogens. ICPEMC Publication No. 12. Inhibitors of mutagenesis and their relevance to carcinogenesis. Report by ICPEMC Expert Group on Antimutagens and Desmutagens. Mu-tat Res 1986;168(1):47-65. doi:10.1016/0165-1110(86)90021-7, PMID:3520303.

[71]

De Flora S, Ramel C. Mechanisms of inhibitors of mutagenesis and car-cinogenesis. Classification and overview. Mutat Res 1988;202(2):285-306. doi:10.1016/0027-5107(88)90193-5, PMID:3057362.

[72]

Gudi VA, Singh SV. Effect of diallyl sulfide, a naturally occurring anti-carcinogen, on glutathione-dependent detoxification enzymes of female CD-1 mouse tissues. Biochem Pharmacol 1991;42(6):1261-1265. doi:10.1016/0006-2952(91)90263-5, PMID:1888335.

[73]

Kim ND, Kim SG, Kwak MK. Enhanced expression of rat microsomal epoxide hydrolase gene by organosulfur compounds. Biochem Phar-macol 1994;47(3):541-547. doi:10.1016/0006-2952(94)90186-4, PMID:8117322.

[74]

Nakamura Y, Miyamoto M, Murakami A, Ohigashi H, Osawa T, Uchida K. A phase II detoxification enzyme inducer from lemongrass: iden-tification of citral and involvement of electrophilic reaction in the enzyme induction. Biochem Biophys Res Commun 2003; 302(3):593-

[75]

Jancova P, Anzenbacher P, Anzenbacherova E. Phase II drug metabo-lizing enzymes. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2010; 154(2):103-116. doi:10.5507/bp.2010.017,PMID:20668491.

[76]

Kapur A, Felder M, Fass L, Kaur J, Czarnecki A, Rathi K, et al. Modu-lation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation. Sci Rep 2016; 6:27530. doi:10.1038/srep27530,PMID:27270209.

[77]

Sanches LJ, Marinello PC, Panis C, Fagundes TR, Morgado-Díaz JA, de-Freitas-Junior JC, et al. Cytotoxicity of citral against melanoma cells: The involvement of oxidative stress generation and cell growth protein reduction. Tumour Biol 2017; 39(3):1010428317695914. doi:10.1177/1010428317695914,PMID:28351318.

[78]

Dudai N, Weinstein Y, Krup M, Rabinski T, Ofir R. Citral is a new induc-er of caspase-3 in tumor cell lines. Planta Med 2005; 71(5):484-488. doi:10.1055/s-2005-864146,PMID:15931590.

[79]

Arunasree KM. Anti-proliferative effects of carvacrol on a hu-man metastatic breast cancer cell line, MDA-MB 231. Phytomedi-cine 2010; 17(8-9):581-588. doi:10.1016/j.phymed.2009.12.008,PMID:20096548.

[80]

Girola N, Figueiredo CR, Farias CF, Azevedo RA, Ferreira AK, Teixeira SF, et al. Camphene isolated from essential oil of Piper cernuum (Piperace-ae) induces intrinsic apoptosis in melanoma cells and displays antitu-mor activity in vivo. Biochem Biophys Res Commun 2015; 467(4):928-934. doi:10.1016/j.bbrc.2015.10.041, PMID:26471302.

[81]

Liu B, Xue Q, Tang Y, Cao J, Guengerich FP, Zhang H. Mechanisms of mutagenesis: DNA replication in the presence of DNA dam-age. Mutat Res Rev Mutat Res 2016; 768:53-67. doi:10.1016/j.mr-rev.2016.03.006,PMID:27234563.

[82]

Elfaki I, Mir R, Almutairi FM, Duhier FMA. Cytochrome P450: Poly-morphisms and Roles in Cancer, Diabetes and Atherosclerosis. Asian Pac J Cancer Prev 2018; 19(8):2057-2070. doi:10.22034/AP-JCP.2018.19.8.2057, PMID:30139042.

[83]

Reed L, Arlt VM, Phillips DH. The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo-in vitro paradox. Carcinogenesis 2018; 39(7):851-859. doi:10.1093/carcin/bgy058,PMID:29726902.

[84]

Sanchez-Dominguez CN, Gallardo-Blanco HL, Salinas-Santander MA, Ortiz-Lopez R. Uridine 5'-diphospho-glucronosyltrasferase: Its role in pharmacogenomics and human disease. Exp Ther Med 2018; 16(1):3-11. doi:10.3892/etm.2018.6184,PMID:29896223.

[85]

Singh RR, Reindl KM. Glutathione S-Transferases in Cancer. Antioxi-dants (Basel) 2021; 10(5):701. doi:10.3390/antiox10050701,PMID:33946704.

[86]

Potęga A. Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation. Molecules 2022; 27(16):5252. doi:10.3390/molecules27165252,PMID:36014491.

[87]

Guengerich FP, Peterson LA, Cmarik JL, Koga N, Inskeep PB. Activa-tion of dihaloalkanes by glutathione conjugation and formation of DNA adducts. Environ Health Perspect 1987; 76:15-8. doi:10.1289/ehp.877615,PMID:3329096.

[88]

Wilce MCJ, Parker MW. Structure and function of glutathione S-transferases. Biochimica et Biophysica Acta 1994; 1205(1):1-18. doi:10.1016/0167-4838(94)90086-8.

[89]

de Wildt SN, Kearns GL, Leeder JS, van den Anker JN. Glucuronidation in humans. Pharmacogenetic and developmental aspects. Clin Phar-macokinet 1999; 36(6):439-452. doi:10.2165/00003088-199936060-00005,PMID:10427468.

[90]

Izumi K, Inoue S, Ide H, Fujita K, Mizushima T, Jiang G, et al. Uridine 5'diphospho-glucuronosyltransferase 1A expression as an inde-pendent prognosticator in urothelial carcinoma of the upper uri-nary tract. Int J Urol 2018; 25(5):429-435. doi:10.1111/iju.13528,PMID:29444544.

[91]

Fischer AH, Wong JYY, Baris D, Koutros S, Karagas MR, Schwenn M, et al. Urine pH and Risk of Bladder Cancer in Northern New Eng-land. Cancer Epidemiol Biomarkers Prev 2023; 32(10):1323-1327. doi:10.1158/1055-9965.EPI-22-0801,PMID:37351876.

[92]

Freudenthal RI, Stephens E, Anderson DP. Determining the Potential of Aromatic Amines to Induce Cancer of the Urinary Bladder. Inter-national Journal of Toxicology 1999; 18(5):353-359. doi:10.1080/109158199225260.

[93]

Cavelier G, Amzel LM. Mechanism of NAD(P)H:quinone reductase: Ab initio studies of reduced flavin. Proteins 2001; 43(4):420-432. doi:10.1002/prot.1055,PMID:11340659.

[94]

Oesch F, Hengstler JG, Arand M. Detoxication strategy of epox-ide hydrolase-the basis for a novel threshold for definable geno-toxic carcinogens. Nonlinearity Biol Toxicol Med 2004; 2(1):21-26. doi:10.1080/15401420490426963,PMID:19330105.

[95]

Toscano-Garibay JD, Arriaga-Alba M, Sánchez-Navarrete J, Mendoza-García M, Flores-Estrada JJ, Moreno-Eutimio MA, et al. Antimutagen-ic and antioxidant activity of the essential oils of Citrus sinensis and Citrus latifolia. Sci Rep 2017; 7(1):11479. doi:10.1038/s41598-017-11818-5,PMID:28904369.

[96]

Vuković-Gacić B, Nikcević S, Berić-Bjedov T, Knezević-Vukcević J, Simić D. Antimutagenic effect of essential oil of sage ( and its monoterpenes against UV-induced mutations in Escherichia coli and Saccharomyces cerevisiae. Food Chem Toxicol 2006; 44(10):1730-1738. doi:10.1016/j.fct.2006.05.011,PMID:16814443.

[97]

Yang Y, Yue Y, Runwei Y, Guolin Z. Cytotoxic, apoptotic and antioxi-dant activity of the essential oil of Amomum tsao-ko. Bioresour Tech-nol 2010; 101(11):4205-4211. doi:10.1016/j.biortech.2009.12.131,PMID:20133123.

[98]

Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, et al. Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells. BMC Complement Altern Med 2011; 11:129. doi:10.1186/1472-6882-11-129,PMID:22171782.

[99]

Silva SLD, Chaar JDS, Figueiredo PDMS, Yano T. Cytotoxic evalua-tion of essential oil from Casearia sylvestris on human cancer cells and erythrocytes. Acta Amazon 2008; 38(1):107-112. doi:10.1590/S0044-59672008000100012.

[100]

Amiel E, Ofir R, Dudai N, Soloway E, Rabinsky T, Rachmilevitch S. β-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis In-ducer for Tumor Cell Lines. Evid Based Complement Alternat Med 2012; 2012:872394. doi:10.1155/2012/872394,PMID:22567036.

[101]

Cetinus E, Temiz T, Ergul M, Altun A, Cetinus S, Kaya T. Thyme es-sential oil inhibits proliferation of DLD-1 colorectal cancer cells through antioxidant effect. Cumhur Medical J 2013; 35(1):14-24. doi:10.7197/1305-0028.1757.

[102]

Javed A, Subasini U, Muath SMA, Esra TA. Essential oil composi-tion and antidiabetic, anticancer activity of Rosmarinus officinalis L. Leaves from Erbil (Iraq). J Essent Oil-Bear Plants 2020; 22(6):1544-1553. doi:10.1080/0972060X.2019.1689179.

[103]

Patil JR, Jayaprakasha GK, Chidambara Murthy KN, Tichy SE, Chetti MB, Patil BS. Apoptosis-mediated proliferation inhibition of human colon cancer cells by volatile principles of Citrus auran-tifolia. Food Chem 2009; 114(4):1351-1358. doi:10.1016/j.food-chem.2008.11.033.

[104]

Eid AM, Jaradat N, Shraim N, Hawash M, Issa L, Shakhsher M, et al. Assessment of anticancer, antimicrobial, antidiabetic, anti-obesity and antioxidant activity of Ocimum Basilicum seeds essential oil from Palestine. BMC Complement Med Ther 2023; 23(1):221. doi:10.1186/s12906-023-04058-w,PMID:37403162.

[105]

Panyajai P, Chueahongthong F, Viriyaadhammaa N, Nirachonkul W, Tima S, Chiampanichayakul S, et al. Anticancer activity of Zin-giber ottensii essential oil and its nanoformulations. PLoS One 2022; 17(1):e0262335. doi:10.1371/journal.pone.0262335,PMID:35073347.

[106]

Amirzadeh M, Soltanian S, Mohamadi N. Chemical composition, anticancer and antibacterial activity of Nepeta mahanensis essen-tial oil. BMC Complement Med Ther 2022; 22(1):173. doi:10.1186/s12906-022-03642-w,PMID:35752826.

[107]

Liu Y, Zhong X, Ding Y, Ren L, Bai T, Liu M, et al. Inhibition of voltage-dependent potassium channels mediates cAMP-potentiated insulin secretion in rat pancreatic β cells. Islets 2017; 9(2):11-18. doi:10.1080/19382014.2017.1280644,PMID:28103136.

[108]

Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroen-terology 2007; 132(6):2131-2157. doi:10.1053/j.gastro.2007.03.054,PMID:17498508.

[109]

Surampudi PN, John-Kalarickal J, Fonseca VA. Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med 2009; 76(3):216-226. doi:10.1002/msj.20113,PMID:19421965.

[110]

Seino Y, Fukushima M, Yabe D. GIP and GLP-1, the two incretin hormones: Similarities and differences. J Diabetes Investig 2010; 1(1-2):8-23. doi:10.1111/j.2040-1124.2010.00022.x, PMID:24843404.

[111]

Roden M, Shulman GI. The integrative biology of type 2 diabetes. Nature 2019; 576(7785):51-60. doi:10.1038/s41586-019-1797-8,PMID:31802013.

[112]

Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol 2021; 320(3):C375-C391. doi:10.1152/ajpcell.00379.2020, PMID:333 56944.

[113]

Wu CH, Huang SM, Lin JA, Yen GC. Inhibition of advanced glycation endproduct formation by foodstuffs. Food Funct 2011; 2(5):224-234. doi:10.1039/c1fo10026b,PMID:21779560.

[114]

Gandhi GR, Hillary VE, Antony PJ, Zhong LLD, Yogesh D, Krishnaku-mar NM, et al. A systematic review on anti-diabetic plant essential oil compounds: Dietary sources, effects, molecular mechanisms, and safety. Crit Rev Food Sci Nutr 2024; 64(19):6526-6545. doi:10.1080/10408398.2023.2170320,PMID:36708221.

[115]

Zarandi MH, Sharifiyazdi H, Nazifi S, Ghaemi M, Bakhtyari MK. Ef-fects of citral on serum inflammatory factors and liver gene expres-sion of IL-6 and TNF-alpha in experimental diabetes. Comp Clin Patho 2021; 30:351-361. doi:10.1007/s00580-021-03205-4.

[116]

Ataie Z, Dastjerdi M, Farrokhfall K, Ghiravani Z. The Effect of Cin-namaldehyde on iNOS Activity and NO-Induced Islet Insulin Secre-tion in High-Fat-Diet Rats. Evid Based Complement Alternat Med 2021; 2021:9970678. doi:10.1155/2021/9970678,PMID:34335851.

[117]

Sadgrove NJ, Padilla-González GF, Leuner O, Melnikovova I, Fernan-dez-Cusimamani E. Pharmacology of Natural Volatiles and Essential Oils in Food, Therapy, and Disease Prophylaxis. Front Pharmacol 2021;12:740302. doi:10.3389/fphar.2021.740302,PMID:34744723.

[118]

Sales PM, Souza PM, Simeoni LA, Silveira D. α-Amylase inhibitors: a review of raw material and isolated compounds from plant source. J Pharm Pharm Sci 2012; 15(1):141-183. doi:10.18433/j35s3k,PMID:22365095.

[119]

Kumar S, Narwal S, Kumar V, Prakash O. α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacogn Rev 2011; 5(9):19-29. doi:10.4103/0973-7847.79096,PMID:22096315.

[120]

Wang S, Ding L, Ji H, Xu Z, Liu Q, Zheng Y. The Role of p 38 MAPK in the Development of Diabetic Cardiomyopathy. Int J Mol Sci 2016; 17(7):1037. doi:10.3390/ijms17071037,PMID:27376265.

[121]

He X, Gao F, Hou J, Li T, Tan J, Wang C, et al. Metformin inhibits MAPK sign-aling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus. J Biol Chem 2021; 297(2):101002. doi:10.1016/j.jbc.2021.101002,PMID:34303707.

[122]

Liadis N, Murakami K, Eweida M, Elford AR, Sheu L, Gaisano HY, et al. Caspase-3-dependent beta-cell apoptosis in the initiation of au-toimmune diabetes mellitus. Mol Cell Biol 2005; 25(9):3620-3629. doi:10.1128/MCB.25.9.3620-3629.2005, PMID:15831467.

[123]

Sun J, Singh P, Österlund J, Orho-Melander M, Melander O, Engström G, et al. Hyperglycaemia-associated Caspase-3 predicts diabetes and coronary artery disease events. J Intern Med 2021; 290(4):855-865. doi:10.1111/joim.13327,PMID:34309093.

[124]

Chang L, Chiang SH, Saltiel AR. Insulin signaling and the regu-lation of glucose transport. Mol Med 2004; 10(7-12):65-71. doi:10.2119/2005-00029.Saltiel,PMID:16307172.

[125]

Alkhateeb HH, Kaplan NM, Al-Duais M. Understanding the Mecha-nism Underlie the Antidiabetic Activity of Oleuropein Using Ex-Vivo Approach. Rep Biochem Mol Biol 2022; 11(1):146-156. doi:10.52547/rbmb.11.1.146,PMID:35765534.

[126]

Wang W, Zhong X, Guo J. Role of 2-series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non-alcoholic fatty liver disease (Review). Int J Mol Med 2021; 47(6):114. doi:10.3892/ijmm.2021.4947,PMID:33907839.

[127]

Kothari V, Galdo JA, Mathews ST. Hypoglycemic agents and po-tential anti-inflammatory activity. J Inflamm Res 2016; 9:27-38. doi:10.2147/JIR.S86917,PMID:27114714.

[128]

Chelladurai GRM, Chinnachamy C. Alpha amylase and Alpha glu-cosidase inhibitory effects of aqueous stem extract of Salacia ob-longa and its GC-MS analysis. Braz J Pharm Sci 2018; 54(1):e17151. doi:10.1590/s2175-97902018000117151.

[129]

Ogunyemi OM, Gyebi GA, Saheed A, Paul J, Nwaneri-Chidozie V, Olorundare O, et al. Inhibition mechanism of alpha-amylase, a diabe-tes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth. Front Mol Biosci 2022;9:866719. doi:10.3389/fmolb.2022.866719,PMID:36032689.

[130]

Fadimu GJ, Farahnaky A, Gill H, Olalere OA, Gan CY, Truong T. In-Sil-ico Analysis and Antidiabetic Effect of α-Amylase and α-Glucosidase Inhibitory Peptides from Lupin Protein Hydrolysate: Enzyme-Pep-tide Interaction Study Using Molecular Docking Approach. Foods 2022; 11(21):3375. doi:10.3390/foods11213375,PMID:36359988.

[131]

Cui Y, Chen J, Zhang Z, Shi H, Sun W, Yi Q. The role of AMPK in macrophage metabolism, function and polarisation. J Transl Med 2023; 21(1):892. doi:10.1186/s12967-023-04772-6,PMID:38066566.

[132]

Boukhris M, Bouaziz M, Feki I, Jemai H, El Feki A, Sayadi S. Hypo-glycemic and antioxidant effects of leaf essential oil of Pelargonium graveolens L'Hér. in alloxan induced diabetic rats. Lipids Health Dis 2012; 11:81. doi:10.1186/1476-511X-11-81,PMID:22734822.

[133]

Muhammad NO, Soji-Omoniwa O, Usman LA, Omoniwa BP. Antihy-perglycemic activity of leaf essential oil of Citrus sinensis (L.) Osbeck on alloxan induced diabetic rats. Annu Res Rev Biol 2013; 3(4):825-834.

[134]

Al-Mijalli SH, Assaggaf H, Qasem A, El-Shemi AG, Abdallah EM, Mrabti HN, et al. Antioxidant, Antidiabetic, and Antibacterial Po-tentials and Chemical Composition of Salvia officinalis and Men-tha suaveolens Grown Wild in Morocco. Adv Pharmacol Pharm Sci 2022; 2022:2844880. doi:10.1155/2022/2844880,PMID:35755940.

[135]

El-Soud NHA, El-Lithy NA, El-Saeed GSM, Wahby MS, Khalil MY, El-Kassem LTA, et al. Efficacy of Coriandrum Sativum L. essential oil as antidiabetic. J Appl Sci Res 2012; 8(7):3646-3655.

[136]

Boukhalfa D, Nabti B. Evaluation of the hypoglycemic and antimi-crobial activities of the essential oil of Myrtus nivellei from Taman-rasset (southern Algeria). GSC Biol Pharm Sci 2023; 22(2):272-279. doi:10.30574/gscbps.2023.22.2.0082.

[137]

Nait Irahal I, Darif D, Guenaou I, Hmimid F, Azzahra Lahlou F, Ez-Zahra Ousaid F, et al. Therapeutic Potential of Clove Essential Oil in Diabe-tes: Modulation of Pro-Inflammatory Mediators, Oxidative Stress and Metabolic Enzyme Activities. Chem Biodivers 2023; 20(3):e202201169. doi:10.1002/cbdv.202201169,PMID:36823346.

[138]

Sebai H, Selmi S, Rtibi K, Souli A, Gharbi N, Sakly M. Lavender (essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. Lipids Health Dis 2013; 12:189. doi:10.1186/1476-511X-12-189,PMID:24373672.

[139]

Assaggaf H, El Hachlafi N, El Fadili M, Elbouzidi A, Ouassou H, Jed-di M, et al. GC/MS profiling, in vitro antidiabetic efficacy of Origa-num compactum Benth. essential oil and in silico molecular dock-ing of its major bioactive compounds. Catalysts 2023; 13(11):1429. doi:10.3390/catal13111429.

[140]

Oboh G, Ademosun AO, Odubanjo OV, Akinbola IA. Antioxidative properties and inhibition of key enzymes relevant to type-2 diabetes and hypertension by essential oils from black pepper. Adv Pharmacol Sci 2013; 2013:926047. doi:10.1155/2013/926047,PMID:24348547.

[141]

Gábor M. Models of acute inflammation in the ear. Methods Mol Biol 2003; 225:129-137. doi:10.1385/1-59259-374-7:129,PMID:12769482.

[142]

Calixto JB, Campos MM, Otuki MF, Santos AR. Part II. Anti-inflammatory compounds of plant origin. modulation of pro-inflamma-tory cytokines, chemokines and adhesion molecules. Planta Med 2004; 70(2):93-103. doi:10.1055/s-2004-815483,PMID:14994184.

[143]

Murakawa M, Yamaoka K, Tanaka Y, Fukuda Y. Involvement of tu-mor necrosis factor (TNF)-alpha in phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced skin edema in mice. Biochem Pharmacol 2006; 71(9):1331-1336. doi:10.1016/j.bcp.2006.01.005,PMID:16487490.

[144]

Karakoy Z, Cadirci E, Dincer B. A new target in inflammatory dis-eases: Lycopene. Eurasian J Med 2022; 54(Suppl 1):S29-S33. doi:10.5152/eurasianjmed.2022.22300.

[145]

Zhao Q, Zhu L, Wang S, Gao Y, Jin F. Molecular mechanism of the an-ti-inflammatory effects of plant essential oils: A systematic review. J Ethnopharmacol 2023;301:115829. doi:10.1016/j.jep.2022.115829,PMID:36252876.

[146]

Dinarello CA. Anti-inflammatory Agents: Present and Future. Cell 2010; 140(6):935-950. doi:10.1016/j.cell.2010.02.043,PMID:20303881.

[147]

Miguel MG. Antioxidant and anti-inflammatory activities of es-sential oils: a short review. Molecules 2010; 15(12):9252-9287. doi:10.3390/molecules15129252,PMID:21160452.

[148]

Ascari J, de Oliveira MS, Nunes DS, Granato D, Scharf DR, Simionatto E, et al. Chemical composition, antioxidant and anti-inflammatory activities of the essential oils from male and female specimens of Baccharis punctulata (Asteraceae). J Ethnopharmacol 2019; 234:1-7. doi:10.1016/j.jep.2019.01.005,PMID:30660710.

[149]

Chen S, Chen H, Du Q, Shen J. Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds. Front Physiol 2020;11:433. doi:10.3389/fphys.2020.00433,PMID:32508671.

[150]

Frangie C, Daher J. Role of myeloperoxidase in inflammation and atherosclerosis (Review). Biomed Rep 2022; 16(6):53. doi:10.3892/br.2022.1536,PMID:35620311.

[151]

Premakumari PD, Kumaraswamy M, Sarayu MG. Anti-inflammatory potential of essential oil from Pogostemon benghalensis (Burm.F.) Kuntze. using animal models. J Adv Sci Res 2020; 11(4):92-99.

[152]

Li R, Yang JJ, Shi YX, Zhao M, Ji KL, Zhang P, et al. Chemical composi-tion, antimicrobial and anti-inflammatory activities of the essential oil from Maqian (Zanthoxylum myriacanthum var. pubescens) in Xishuangbanna, SW China. J Ethnopharmacol 2014;158(Pt A):43-48. doi:10.1016/j.jep.2014.10.006,PMID:25448503.

[153]

Lorençoni MF, Figueira MM, Toledo e Silva MV, Pimentel Schmitt EF, Endringer DC, Scherer R, et al. Chemical composition and anti-inflammatory activity of essential oil and ethanolic extract of Cam-pomanesia phaea (O. Berg.) Landrum leaves. J Ethnopharmacol 2020;252:112562. doi:10.1016/j.jep.2020.112562,PMID:31954197.

[154]

Otunola GA, Afolayan AJ. Chemical composition, antibacterial and in vitro anti-inflammatory potentials of essential oils from differ-ent plant parts of Moringa Oleifera Lam. Am J Biochem Biotechnol 2018; 14(3):210-220. doi:10.3844/ajbbsp.2018.210.220.

[155]

Sharma AD, Kaur I, Singh N. Tryptophan fluorescence spectroscopy: key tool to study protein denaturation/anti-inflammatory assay. Re-search & Reviews in Biotechnology & Biosciences 2021; 8(1):90-94. doi:10.5281/zenodo.5118388.

[156]

Acharya VV Chaudhari. Modalities of protein denaturation and nature of denaturants. Int J Pharm Sci Rev Res 2021; 69(2):19-24. doi:10.47583/ijpsrr.2021.v69i02.002.

[157]

Cimonara MC. Lysosomes, lysosomal storage diseases and inflam-mation. J Inborn Errors Metab Screen 2016; 4:1-8. doi:10.1177/2326409816650465.

[158]

An BS, Kang JH, Yang H, Jung EM, Kang HS, Choi IG, et al. Anti-in-flammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats. Mol Med Rep 2013; 8(1):255-259. doi:10.3892/mmr.2013.1459, PMID:23652412.

[159]

Belkhodja H, Meddah B, Sidelarbi K, Bouhadi D, Medjadel B, Brak-na A. In vitro and in vivo anti-inflammatory potential of Eucalyptus globulus essential oil. J Appl Biosci 2022; 16(1):80-88. doi:10.5281/zenodo.5826169.

[160]

Pandur E, Balatinácz A, Micalizzi G, Mondello L, Horváth A, Sipos K, et al. Anti-inflammatory effect of lavender (Lavandula angustifolia Mill.) essential oil prepared during different plant phenophases on THP-1 macrophages. BMC Complement Med Ther 2021; 21(1):287. doi:10.1186/s12906-021-03461-5,PMID:34819075.

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