fatigue is a common symptom in patients with malignant tumors, which seriously affects patient quality of life and even the progress of treatment. There have been numerous studies on various aspects of cancer-related fatigue. This review summarizes and analyzes its pathogenesis, screening, evaluation, and treatment from the perspectives of modern medicine and traditional Chinese medicine (TCM). Modern medicine believes that the pathogenesis of cancer-related fatigue is still unclear. Screening assessment scales are varied and have different focuses, so they should be selected and used comprehensively. Drug intervention for cancer-related fatigue has safety problems and is not recommended for conventional treatment. Non-drug treatment methods such as exercise, psychological intervention, diet guidance, and light therapy have good efficacy and high safety and are worthy of clinical promotion. In TCM, cancer fatigue is included as a deficiency. The syndrome of TCM is divided into two categories: deficiency syndrome and syndrome of intermingled deficiency and excess, involving the three viscera, the liver, spleen, and kidney that are closely related to the pathological products of blood stasis, toxin, phlegm, and dampness. The TCM diagnosis and evaluation scale is still in its infancy, which objectively quantifies TCM syndromes, forms a unified diagnostic standard for TCM syndrome differentiation, and standardizes TCM syndrome differentiation and treatment. The elements of syndromes open the idea of constructing a TCM scale. TCM offers various treatment and nursing methods that have high efficacy and safety. TCM, acupuncture, moxibustion, and traditional exercises are the main methods, but high-quality evidence is needed. In the future, the advantages of the combination of TCM and Western medicine should be used to overcome cancer-related fatigue.
Acknowledgments
There is nothing to declare.
Funding
This research was supported by the scientific research project of the Hebei administration of traditional Chinese medicine (Grant No.: 2023045; 2024023); the 2022 medical research project of Hebei province (Grant No.: 20220962); 2023 government-funded project of the Outstanding Talents Training Program in Clinical Medicine (Grant No.: ZF2023165).
Conflict of interest
DHL has been an editorial board member of Future Integrative Medicine since November 2021. The other author reports no con-flict of interests in this work.
Author contributions
Design of the research and writing and revision (XLD, DHL, RJL, CLM), collecting the data, and translating the manuscript (XLD, JPZ). The final manuscript was read and approved by all authors.
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