Background and Aims: Chemotherapy-induced nausea and vomiting (CINV) are both common clinical problems in cancer patients. As a traditional Chinese medicine treatment method, acupuncture has a remarkable healing effect on the treatment of nausea and vomiting, but a systematic meta-analysis is lacking concerning this topic.
Methods This paper searched the randomized controlled clinical trial literature on acupuncture for the prevention of CINV in the Pubmed, EMBASE, CNKI, WF (WAFANG DATE), Cochrane, and VIP (CQVIP) databases with a search date of October 20, 2021. An independent quality evaluation and effect size extraction of the literature were performed by two researchers, and the meta-analysis and quality evaluation of all the literature was performed using RevMan 5.4. A total of 18 publications meeting the criteria were screened for the meta-analysis with a total of 1,135 patients.
Results Combined acupuncture prophylaxis was significantly better than other chemotherapy regimens in comparison with conventional chemotherapy regimens (risk ratio (RR) = 1.29; 95% confidence interval (CI): 1.17-1.43, p < 0.00001; odds ratio (OR) = 3.61; 95% CI: 2.19-5.96, p < 0.00001). Combined acupuncture was also effective in the prevention of side effects, such as loss of appetite (RR = 0.64; 95% CI:0.42-0.97, p < 0.00001; OR = 0.52; 95% CI:0.28-0.96, p = 0.04), constipation (RR = 0.57; 95% CI :0.44-0.73, p < 0.00001; OR = 0.30; 95% CI:0.18-0.51, p < 0.00001), and diarrhea (RR = 0.58; 95% CI:0.39-0.86, p < 0.00001; OR = 0.31; 95% CI:0.13-0.72, p < 0.00001).
Conclusions: Acupuncture prevention could reduce the incidence of CINV which has certain research value and thus would be worthy of research trials and clinical application.
Acknowledgments
None.
Funding
This research was supported by the National Natural Science Foundation of China (Grant no. 81603412); Hebei Province “Three Three Three Talent Project” funded project (Grant no. A202002008). General Projects for Improving Scientific Research Capacity of Hebei College of Traditional Chinese Medicine (Grant no. KTY2019009); Key Laboratory of Integrated Traditional Chinese and Western Medicine Hepatonephrosis in Hebei Province (Grant no. A201902), 2022 Medical science research project of Hebei Province (20220962).
Conflict of interest
DHL has been an editorial board member of Future Integrative Medicine since November 2021. The other authors report no conflict of interests in this work.
Author contributions
DHL, JNZ, and HFF designed the research, prepared the data, wrote and revised the manuscript; XKL, JL, NG, ZHD, and HNW collected the data and translated the manuscript. The final manuscript was read and approved by all authors.
Data sharing statement
The data used to support the findings of this study are available from the corresponding author upon request.
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