Received date: 14 Dec 2011
Accepted date: 04 Feb 2012
Published date: 01 Jun 2013
Copyright
Oxidative stress and the accumulation of reactive oxygen specie (ROS) play a role in cancer cells developing an advanced, phenotypic signature that associates with metastasis and progression. Increased ROS concentrations are involved in promoting cancer development and metastasis by inducing expression of oncogenes, suppressing activity of anti-survival molecules and by activating various cell survival and proliferation signaling pathways. Oxidative stress is higher in the epithelium of cancer patients than patients without the disease, and antioxidant trials are currently being explored as a therapeutic option. However, studies have shown that ROS increases expression of CXCR4 in cancer and immune cells. CXCR4 expression in tumors strongly correlates to metastasis and poor prognosis. Herein, we discuss an emerging relationship between ROS and CXCR4 in cancer cells.
Key words： reactive oxygen species; CXCR4; HIF1α; metastasis; PI3K/AKT; ERK1/2
Mahandranauth A. CHETRAM , Cimona V. HINTON . ROS-mediated regulation of CXCR4 in cancer[J]. Frontiers in Biology, 2013 , 8(3) : 273 -278 . DOI: 10.1007/s11515-012-1204-4
| 1 |
Ammendola R, Mesuraca M, Russo T, Cimino F (1994). The DNA-binding efficiency of Sp1 is affected by redox changes. Eur J Biochem, 225(1): 483-489
|
| 2 |
Balabanian K, Lagane B, Infantino S, Chow K Y, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F (2005). The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem, 280(42): 35760-35766
|
| 3 |
Busillo J M, Benovic J L (2007). Regulation of CXCR4 signaling. Biochim Biophys Acta, 1768(4): 952-963
|
| 4 |
Chetram M A, Odero-Marah V, Hinton C V (2011). Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells. Mol Cancer Res, 9(1): 90-102
|
| 5 |
Cho Y H, Shen J, Gammon M D, Zhang Y J, Wang Q, Gonzalez K, Xu X, Bradshaw P T, Teitelbaum S L, Garbowski G, Hibshoosh H, Neugut A I, Chen J, Santella R M (2012). Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients. Breast Cancer Res Treat, 131(1): 197-205
|
| 6 |
Circu M L, Aw T Y (2010). Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med, 48(6): 749-762
|
| 7 |
Cook J A, Gius D, Wink D A, Krishna M C, Russo A, Mitchell J B (2004). Oxidative stress, redox, and the tumor microenvironment. Semin Radiat Oncol, 14(3): 259-266
|
| 8 |
Cruz-Orengo L, Holman D W, Dorsey D, Zhou L, Zhang P, Wright M, McCandless E E, Patel J R, Luker G D, Littman D R, Russell J H, Klein R S (2011). CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. J Exp Med, 208(2): 327-339
|
| 9 |
Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, Kao WM, Battista M, Tesio M, Kollet O (2011). Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells. Leukemia, 25(8):1286-1296
|
| 10 |
Davies K J (1993). Protein modification by oxidants and the role of proteolytic enzymes. Biochem Soc Trans, 21(2): 346-353
|
| 11 |
Esposito F, Cuccovillo F, Morra F, Russo T, Cimino F (1995). DNA binding activity of the glucocorticoid receptor is sensitive to redox changes in intact cells. Biochim Biophys Acta, 1260(3): 308-314
|
| 12 |
Fraga C G, Shigenaga M K, Park J W, Degan P, Ames B N (1990). Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA, 87(12): 4533-4537
|
| 13 |
Galaris D, Skiada V, Barbouti A (2008). Redox signaling and cancer: the role of “labile” iron. Cancer Lett, 266(1): 21-29
|
| 14 |
Gerard C, Rollins B J (2001). Chemokines and disease. Nat Immunol, 2(2): 108-115
|
| 15 |
Gupta A, Rosenberger S F, Bowden G T (1999). Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis, 20(11): 2063-2073
|
| 16 |
Gupta S K, Lysko P G, Pillarisetti K, Ohlstein E, Stadel J M (1998). Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem, 273(7): 4282-4287
|
| 17 |
Guyton K Z, Liu Y, Gorospe M, Xu Q, Holbrook N J (1996). Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem, 271(8): 4138-4142
|
| 18 |
Ha H L, Yu D Y (2010). HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway. World J Gastroenterol, 16(39): 4932-4937
|
| 19 |
Hambali Z, Ahmad Z, Arab S, Khazaai H (2011). Oxidative stress and its association with cardiovascular disease in chronic renal failure patients. Indian J Nephrol, 21(1): 21-25
|
| 20 |
Hinton C V, Avraham S, Avraham H K (2010). Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Clin Exp Metastasis, 27(2): 97-105
|
| 21 |
Kucia M, Jankowski K, Reca R, Wysoczynski M, Bandura L, Allendorf D J, Zhang J, Ratajczak J, Ratajczak M Z (2004). CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol, 35(3): 233-245
|
| 22 |
Kumar B, Koul S, Khandrika L, Meacham R B, Koul H K (2008). Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res, 68(6): 1777-1785
|
| 23 |
Landriscina M, Maddalena F, Laudiero G, Esposito F (2009). Adaptation to oxidative stress, chemoresistance, and cell survival. Antioxid Redox Signal, 11(11): 2701-2716
|
| 24 |
Lau E K, Allen S, Hsu A R, Handel T M (2004). Chemokine-receptor interactions: GPCRs, glycosaminoglycans and viral chemokine binding proteins. Adv Protein Chem, 68: 351-391
|
| 25 |
Lee R L, Westendorf J, Gold M R (2007). Differential role of reactive oxygen species in the activation of mitogen-activated protein kinases and Akt by key receptors on B-lymphocytes: CD40, the B cell antigen receptor, and CXCR4. J Cell Commun Signal, 1(1): 33-43
|
| 26 |
Lee S R, Yang K S, Kwon J, Lee C, Jeong W, Rhee S G (2002). Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem, 277(23): 20336-20342
|
| 27 |
Li S, Deng Y, Feng J, Ye W (2009). Oxidative preconditioning promotes bone marrow mesenchymal stem cells migration and prevents apoptosis. Cell Biol Int, 33(3): 411-418
|
| 28 |
Lin W, Wu G, Li S, Weinberg E M, Kumthip K, Peng L F, Méndez-Navarro J, Chen W C, Jilg N, Zhao H, Goto K, Zhang L, Brockman M A, Schuppan D, Chung R T (2011). HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB. J Biol Chem, 286(4): 2665-2674
|
| 29 |
Lindahl T (1993). Instability and decay of the primary structure of DNA. Nature, 362(6422): 709-715
|
| 30 |
Liou G Y, Storz P (2010). Reactive oxygen species in cancer. Free Radic Res, 44(5): 479-496
|
| 31 |
Liu L Z, Hu X W, Xia C, He J, Zhou Q, Shi X, Fang J, Jiang B H (2006). Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells. Free Radic Biol Med, 41(10): 1521-1533
|
| 32 |
Liu J, Zhang Y, Zhao J, Yang Z, Li D, Katirai F, Huang B (2011). Mast cell: insight into remodeling a tumor microenvironment. Cancer Metastasis Rev, 30(2):177-184
|
| 33 |
Loetscher P, Moser B, Baggiolini M (2000). Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv Immunol, 74: 127-180
|
| 34 |
Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan M E, McClanahan T, Murphy E, Yuan W, Wagner S N, Barrera J L, Mohar A, Verástegui E, Zlotnik A (2001). Involvement of chemokine receptors in breast cancer metastasis. Nature, 410(6824): 50-56
|
| 35 |
Nelson W G, De Marzo A M, DeWeese T L, Isaacs W B (2004). The role of inflammation in the pathogenesis of prostate cancer. J Urol, 172(5): 6-12
|
| 36 |
Ozben T (2007). Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci, 96(9): 2181-2196
|
| 37 |
Pan J S, Hong M Z, Ren J L (2009). Reactive oxygen species: a double-edged sword in oncogenesis. World J Gastroenterol, 15(14): 1702-1707
|
| 38 |
Pani G, Galeotti T, Chiarugi P (2010). Metastasis: cancer cell’s escape from oxidative stress. Cancer Metastasis Rev, 29(2): 351-378
|
| 39 |
Rains J L, Jain S K (2011). Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med, 50(5): 567-575
|
| 40 |
Saini V, Staren D M, Ziarek J J, Nashaat Z N, Campbell E M, Volkman B F, Marchese A, Majetschak M (2011). The CXC chemokine receptor 4 ligands ubiquitin and stromal-cell derived factor-1{alpha} function through distinct receptor interactions. J Biol Chem, 286(38): 33466-33477
|
| 41 |
Salmeen A, Andersen J N, Myers M P, Meng T C, Hinks J A, Tonks N K, Barford D (2003). Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature, 423(6941): 769-773
|
| 42 |
Simon H U, Haj-Yehia A, Levi-Schaffer F (2000). Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis, 5(5): 415-418
|
| 43 |
Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley E J, Krek W (2003). Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature, 425(6955): 307-311
|
| 44 |
Storz P (2005). Reactive oxygen species in tumor progression. Front Biosci, 10(1-3): 1881-1896
|
| 45 |
Taichman R S, Cooper C, Keller E T, Pienta K J, Taichman N S, McCauley L K (2002). Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res, 62(6): 1832-1837
|
| 46 |
Talks K L, Turley H, Gatter K C, Maxwell P H, Pugh C W, Ratcliffe P J, Harris A L (2000). The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol, 157(2): 411-421
|
| 47 |
Tanabe S, Heesen M, Yoshizawa I, Berman M A, Luo Y, Bleul C C, Springer T A, Okuda K, Gerard N, Dorf M E (1997). Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. J Immunol, 159(2): 905-911
|
| 48 |
Tchou J C, Lin X, Freije D, Isaacs W B, Brooks J D, Rashid A, De Marzo A M, Kanai Y, Hirohashi S, Nelson W G (2000). GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. Int J Oncol, 16(4): 663-676
|
| 49 |
Tomic J, Lichty B, Spaner D E (2011). Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia. Blood, 117(9): 2668-2680
|
| 50 |
Turrens J F (2003). Mitochondrial formation of reactive oxygen species. J Physiol, 552(2): 335-344
|
| 51 |
Wagner B A, Buettner G R, Burns C P (1994). Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content. Biochemistry, 33(15): 4449-4453
|
| 52 |
Wang G L, Jiang B H, Rue E A, Semenza G L (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA, 92(12): 5510-5514
|
| 53 |
Wang J, Wang J, Dai J, Jung Y, Wei C L, Wang Y, Havens A M, Hogg P J, Keller E T, Pienta K J, Nor J E, Wang C Y, Taichman R S (2007). A glycolytic mechanism regulating an angiogenic switch in prostate cancer. Cancer Res, 67(1): 149-159
|
| 54 |
Wu W S, Tsai R K, Chang C H, Wang S, Wu J R, Chang Y X (2006). Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2. Mol Cancer Res, 4(10): 747-758
|
| 55 |
Zhong H, Semenza G L, Simons J W, De Marzo A M (2004). Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detect Prev, 28(2): 88-93
|
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