Antitumor mechanism of Se-containing polysaccharide, a novel organic selenium compound

Abstract

Recent studies on the inhibition of tumor growth by Se-containing polysaccharide were reviewed. Meanwhile, the possible molecular mechanisms of the inhibition of tumor cell growth through antioxidation, induction of tumor cell apoptosis, blockade of cell cycle, and enhancement of immunity by Se-containing polysaccharide were proposed. In the end, the potential application of Se-containing polysaccharide in the prevention and treatment of tumor was elucidated.

Key words： Se-containing polysaccharide; antitumor; antioxidant; organic selenium; apoptosis

Acknowledgements

The study was supported by the National Natural Science Foundation of China (Grant No. 30770276).

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