Differential regulation of cPLA2 and iPLA2 expression in the brain
Received date: 08 Oct 2012
Accepted date: 12 Oct 2012
Published date: 01 Dec 2012
Copyright
The phospholipase A2 (PLA2) family members are critical regulators of membrane structure and lipid composition and have been implicated in neuroinflammation, oxidative stress and neurodegeneration. Here, we review the published data describing regulation of cPLA2 and iPLA2 gene expression. Based on promoter sequence, cPLA2 expression can be regulated by glucocorticoid and pro-inflammatory cytokines, whereas transcription of iPLA2 can be controlled in response to sterol level. RNA degradation in 3′ UTR and epigenetic mechanisms may be involved in the regulation of cPLA2 and iPLA2 expression, respectively. MicroRNA target sequences lie within cPLA2 and iPLA2 mRNAs. Together, these findings indicate differential regulation of cPLA2 and iPLA2 expression. It is hoped that determination of diverse regulatory mechanisms of the PLA2 family may open new doors for development of novel therapeutic compounds that modulate PLA2 expression and function in the treatment of brain diseases.
Kazuhiro TANAKA , Nikhat J. SIDDIQI , Abdullah S. ALHOMIDA , Akhlaq A. FAROOQUI , Wei-Yi ONG . Differential regulation of cPLA2 and iPLA2 expression in the brain[J]. Frontiers in Biology, 2012 , 7(6) : 514 -521 . DOI: 10.1007/s11515-012-9247-0
1 |
Adler D H, Cogan J D, Phillips J A 3rd , Schnetz-Boutaud N, Milne G L, Iverson T, Stein J A, Brenner D A, Morrow J D, Boutaud O, Oates J A (2008). Inherited human cPLA(2α) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest, 118(6): 2121–2131
|
2 |
Adler V, Yin Z, Tew K D, Ronai Z (1999). Role of redox potential and reactive oxygen species in stress signaling. Oncogene, 18(45): 6104–6111
|
3 |
Alexandrov P N, Cui J G, Lukiw W J (2006). Hypoxia-sensitive domain in the human cytosolic phospholipase A2 promoter. Neuroreport, 17(3): 303–307
|
4 |
Arai K, Ikegaya Y, Nakatani Y, Kudo I, Nishiyama N, Matsuki N (2001). Phospholipase A2 mediates ischemic injury in the hippocampus: a regional difference of neuronal vulnerability. Eur J Neurosci, 13(12): 2319–2323
|
5 |
Bao S, Bohrer A, Ramanadham S, Jin W, Zhang S, Turk J (2006a). Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells. J Biol Chem, 281(1): 187–198
|
6 |
Bao S, Song H, Wohltmann M, Ramanadham S, Jin W, Bohrer A, Turk J (2006b). Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis. J Biol Chem, 281(30): 20958–20973
|
7 |
Bickford J S, Newsom K J, Herlihy J D, Mueller C, Keeler B, Qiu X, Walters J N, Su N, Wallet S M, Flotte T R, Nick H S (2012). Induction of group IVC phospholipase A2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells. Biochem J, 442(1): 127–137
|
8 |
Chi P L, Luo S F, Hsieh H L, Lee I T, Hsiao L D, Chen Y L, Yang C M (2011). Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1β via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-κB activity in human rheumatoid arthritis synovial fibroblasts. Arthritis Rheum, 63(10): 2905–2917
|
9 |
Clemens J A, Stephenson D T, Smalstig E B, Roberts E F, Johnstone E M, Sharp J D, Little S P, Kramer R M (1996). Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat. Stroke, 27(3): 527–535
|
10 |
Cowan M J, Yao X L, Pawliczak R, Huang X, Logun C, Madara P, Alsaaty S, Wu T, Shelhamer J H (2004). The role of TFIID, the initiator element and a novel 5′ TFIID binding site in the transcriptional control of the TATA-less human cytosolic phospholipase A2-alpha promoter. Biochim Biophys Acta, 1680(3): 145–157
|
11 |
Farooqui A A (2010). Studies on plasmalogen-selective phospholipase A2 in brain. Mol Neurobiol, 41(2–3): 267–273
|
12 |
Farooqui A A, Antony P, Ong W Y, Horrocks L A, Freysz L (2004). Retinoic acid-mediated phospholipase A2 signaling in the nucleus. Brain Res Brain Res Rev, 45(3): 179–195
|
13 |
Farooqui A A, Ong W Y, Farooqui T (2010). Lipid mediators in the nucleus: Their potential contribution to Alzheimer’s disease. Biochim Biophys Acta, 1801(8): 906–916
|
14 |
Farooqui A A, Ong W Y, Horrocks L A (2006). Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol Rev, 58(3): 591–620
|
15 |
Farooqui A A, Ong W Y, Horrocks L A, Farooqui T (2000). Brain cytosolic phospholipase A2: Localization, role, and involvement in neurological diseases. Neuroscientist, 6(3): 169–180
|
16 |
Farooqui A A, Yang H C, Rosenberger T A, Horrocks L A (1997). Phospholipase A2 and its role in brain tissue. J Neurochem, 69(3): 889–901
|
17 |
Fitzpatrick J S, Baudry M (1994). Blockade of long-term depression in neonatal hippocampal slices by a phospholipase A2 inhibitor. Brain Res Dev Brain Res, 78(1): 81–86
|
18 |
Fujita S, Ikegaya Y, Nishikawa M, Nishiyama N, Matsuki N (2001). Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices. Br J Pharmacol, 132(7): 1417–1422
|
19 |
Gregory A, Westaway S K, Holm I E, Kotzbauer P T, Hogarth P, Sonek S, Coryell J C, Nguyen T M, Nardocci N, Zorzi G, Rodriguez D, Desguerre I, Bertini E, Simonati A, Levinson B, Dias C, Barbot C, Carrilho I, Santos M, Malik I, Gitschier J, Hayflick S J (2008). Neurodegeneration associated with genetic defects in phospholipase A(2). Neurology, 71(18): 1402–1409
|
20 |
Gubern A, Barceló-Torns M, Barneda D, López J M, Masgrau R, Picatoste F, Chalfant C E, Balsinde J, Balboa M A, Claro E (2009). JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2. J Biol Chem, 284(47): 32359–32369
|
21 |
Guo C, Li J, Myatt L, Zhu X, Sun K (2010). Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. Mol Endocrinol, 24(5): 1052–1061
|
22 |
Huang W, Bhavsar A, Ward R E, Hall J C, Priestley J V, Michael-Titus A T (2009). Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury. J Neurotrauma, 26(8): 1429–1434
|
23 |
Jenkins C M, Mancuso D J, Yan W, Sims H F, Gibson B, Gross R W (2004). Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem, 279(47): 48968–48975
|
24 |
Kurian M A, Morgan N V, MacPherson L, Foster K, Peake D, Gupta R, Philip S G, Hendriksz C, Morton J E, Kingston H M, Rosser E M, Wassmer E, Gissen P, Maher E R (2008). Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN). Neurology, 70(18): 1623–1629
|
25 |
Kusenda B, Mraz M, Mayer J, Pospisilova S (2006). MicroRNA biogenesis, functionality and cancer relevance. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 150(2): 205–215
|
26 |
Larsson Forsell P K, Kennedy B P, Claesson H E (1999). The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene. Eur J Biochem, 262(2): 575–585
|
27 |
Lee C W, Lee I T, Lin C C, Lee H C, Lin W N, Yang C M (2010). Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs/p300 and NF-kappaB. J Cell Biochem, 109(5): 1045–1056
|
28 |
Lee C W, Lin C C, Lee I T, Lee H C, Yang C M (2011). Activation and induction of cytosolic phospholipase A2 by TNF-α mediated through Nox2, MAPKs, NF-κB, and p300 in human tracheal smooth muscle cells. J Cell Physiol, 226(8): 2103–2114
|
29 |
Lee L H, Shui G, Farooqui A A, Wenk M R, Tan C H, Ong W Y (2009 a). Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids? Int J Neuropsychopharmacol, 12(7): 953–964
|
30 |
Lee L H, Tan C H, Shui G, Wenk M R, Ong W Y (2012). Role of prefrontal cortical calcium independent phospholipase A₂ in antidepressant-like effect of maprotiline. Int J Neuropsychopharmacol, 15(8): 1087–1098
|
31 |
Lee L Y, Farooqui A A, Dawe G S, Burgunder J M, Ong W Y (2009 b). Role of phospholipase A(2) in prepulse inhibition of the auditory startle reflex in rats. Neurosci Lett, 453(1): 6–8
|
32 |
Li X, Stark G R (2002). NFrB-dependent signaling pathways. Exp Hematol, 30(4): 285–296
|
33 |
Liao W L, Wang W C, Chang W C, Tseng J T (2011). The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 Cells. J Biol Chem, 286(41): 35499–35508
|
34 |
Lin C C, Lin W N, Cheng S E, Tung W H, Wang H H, Yang C M (2012). Transactivation of EGFR/PI3K/Akt involved in ATP-induced inflammatory protein expression and cell motility. J Cell Physiol, 227(4): 1628–1638
|
35 |
Lu X R, Ong W Y, Halliwell B, Horrocks L A, Farooqui A A (2001). Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampal slices. Free Radic Biol Med, 30(11): 1263–1273
|
36 |
Ma Z, Turk J (2001). The molecular biology of the group VIA Ca2+-independent phospholipase A2. Prog Nucleic Acid Res Mol Biol, 67: 1–33
|
37 |
Ma Z, Wang X, Nowatzke W, Ramanadham S, Turk J (1999). Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1. J Biol Chem, 274(14): 9607–9616
|
38 |
Mascaró C, Ortiz J A, Ramos M M, Haro D, Hegardt F G (2000). Sterol regulatory element binding protein-mediated effect of fluvastatin on cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase transcription. Arch Biochem Biophys, 374(2): 286–292
|
39 |
Maxwell A P, Goldberg H J, Tay A H, Li Z G, Arbus G S, Skorecki K L (1993). Epidermal growth factor and phorbol myristate acetate increase expression of the mRNA for cytosolic phospholipase A2 in glomerular mesangial cells. Biochem J, 295(Pt 3): 763–766
|
40 |
Morgan N V, Westaway S K, Morton J E, Gregory A, Gissen P, Sonek S, Cangul H, Coryell J, Canham N, Nardocci N, Zorzi G, Pasha S, Rodriguez D, Desguerre I, Mubaidin A, Bertini E, Trembath R C, Simonati A, Schanen C, Johnson C A, Levinson B, Woods C G, Wilmot B, Kramer P, Gitschier J, Maher E R, Hayflick S J (2006). PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron. Nat Genet, 38(7): 752–754
|
41 |
Morri H, Ozaki M, Watanabe Y (1994). 5′-flanking region surrounding a human cytosolic phospholipase A2 gene. Biochem Biophys Res Commun, 205(1): 6–11
|
42 |
Murakami M, Taketomi Y, Miki Y, Sato H, Hirabayashi T, Yamamoto K (2011a). Recent progress in phospholipase A2 research: from cells to animals to humans. Prog Lipid Res, 50(2): 152–192
|
43 |
Murakami M, Taketomi Y, Sato H, Yamamoto K (2011b). Secreted phospholipase A2 revisited. J Biochem, 150(3): 233–255
|
44 |
Ong W Y, Farooqui T, Farooqui A A (2010). Involvement of cytosolic phospholipase A(2), calcium independent phospholipase A(2) and plasmalogen selective phospholipase A(2) in neurodegenerative and neuropsychiatric conditions. Curr Med Chem, 17(25): 2746–2763
|
45 |
Ong W Y, Lu X R, Ong B K, Horrocks L A, Farooqui A A, Lim S K (2003). Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury. Exp Brain Res, 148(4): 521–524
|
46 |
Ong W Y, Sandhya T L, Horrocks L A, Farooqui A A (1999). Distribution of cytoplasmic phospholipase A2 in the normal rat brain. J Hirnforsch, 39(3): 391–400
|
47 |
Ong W Y, Yeo J F, Ling S F, Farooqui A A (2005). Distribution of calcium-independent phospholipase A2 (iPLA2) in monkey brain. J Neurocytol, 34(6): 447–458
|
48 |
Owada Y, Tominaga T, Yoshimoto T, Kondo H (1994). Molecular cloning of rat cDNA for cytosolic phospholipase A2 and the increased gene expression in the dentate gyrus following transient forebrain ischemia. Brain Res Mol Brain Res, 25(3–4): 364–368
|
49 |
Phillis J W, O’Regan M H (1996). Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortex. Brain Res, 730(1-2): 150–164
|
50 |
Quistad G B, Barlow C, Winrow C J, Sparks S E, Casida J E (2003). Evidence that mouse brain neuropathy target esterase is a lysophospholipase. Proc Natl Acad Sci USA, 100(13): 7983–7987
|
51 |
Reed K A, Tucker D E, Aloulou A, Adler D, Ghomashchi F, Gelb M H, Leslie C C, Oates J A, Boutaud O (2011). Functional characterization of mutations in inherited human cPLA2 deficiency. Biochemistry, 50(10): 1731–1738
|
52 |
Roglans N, Verd J C, Peris C, Alegret M, Vázquez M, Adzet T, Díaz C, Hernández G, Laguna J C, Sánchez R M (2002). High doses of atorvastatin and simvastatin induce key enzymes involved in VLDL production. Lipids, 37(5): 445–454
|
53 |
Sandhya T L, Ong W Y, Horrocks L A, Farooqui A A (1998). A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesions. Brain Res, 788(1–2): 223–231
|
54 |
Schaeffer E L, da Silva E R, Novaes B A, Skaf H D, Gattaz W F (2010). Differential roles of phospholipases A2 in neuronal death and neurogenesis: implications for Alzheimer disease. Prog Neuropsychopharmacol Biol Psychiatry, 34(8): 1381–1389
|
55 |
Seashols S J, del Castillo Olivares A, Gil G, Barbour S E (2004). Regulation of group VIA phospholipase A2 expression by sterol availability. Biochim Biophys Acta, 1684(1–3): 29–37
|
56 |
Sundaram J R, Chan E S, Poore C P, Pareek T K, Cheong W F, Shui G, Tang N, Low C M, Wenk M R, Kesavapany S (2012). Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration. J Neurosci, 32(3): 1020–1034
|
57 |
Takai D, Jones P A (2003). The CpG island searcher: a new WWW resource. In Silico Biol, 3(3): 235–240
|
58 |
Talbot K, Young R A, Jolly-Tornetta C, Lee V M, Trojanowski J Q, Wolf B A (2000). A frontal variant of Alzheimer’s disease exhibits decreased calcium-independent phospholipase A2 activity in the prefrontal cortex. Neurochem Int, 37(1): 17–31
|
59 |
Tang J, Kriz R W, Wolfman N, Shaffer M, Seehra J, Jones S S (1997). A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs. J Biol Chem, 272(13): 8567–8575
|
60 |
Tay A, Maxwell P, Li Z G, Goldberg H, Skorecki K (1994). Cytosolic phospholipase A2 gene expression in rat mesangial cells is regulated post-transcriptionally. Biochem J, 304(Pt 2): 417–422
|
61 |
Tomiyama H, Yoshino H, Ogaki K, Li L, Yamashita C, Li Y, Funayama M, Sasaki R, Kokubo Y, Kuzuhara S, Hattori N (2011). PLA2G6 variant in Parkinson’s disease. J Hum Genet, 56(5): 401–403
|
62 |
Tsou J H, Chang K Y, Wang W C, Tseng J T, Su W C, Hung L Y, Chang W C, Chen B K (2008). Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2alpha in phorbol ester-treated non-small cell lung cancer A549 cells. Nucleic Acids Res, 36(1): 217–227
|
63 |
Umeno J, Matsumoto T, Esaki M, Kukita Y, Tahira T, Yanaru-Fujisawa R, Nakamura S, Arima H, Hirahashi M, Hayashi K, Iida M (2010). Impact of group IVA cytosolic phospholipase A2 gene polymorphisms on phenotypic features of patients with familial adenomatous polyposis. Int J Colorectal Dis, 25(3): 293–301
|
64 |
Wolf M J, Izumi Y, Zorumski C F, Gross R W (1995). Long-term potentiation requires activation of calcium-independent phospholipase A2. FEBS Lett, 377(3): 358–362
|
65 |
Wu T, Ikezono T, Angus C W, Shelhamer J H (1994a). Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene. Nucleic Acids Res, 22(23): 5093–5098
|
66 |
Wu T, Levine S J, Lawrence M G, Logun C, Angus C W, Shelhamer J H (1994b). Interferon-gamma induces the synthesis and activation of cytosolic phospholipase A2. J Clin Invest, 93(2): 571–577
|
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