Molecular mechanisms of transcription and replication of the influenza A virus genome
Received date: 18 Mar 2011
Accepted date: 06 May 2011
Published date: 01 Dec 2011
Copyright
Influenza A virus is one of the major pathogens that pose a large threat to human health worldwide and has caused pandemics. Influenza A virus is the Orthomyxoviridae prototype, and has 8 segmented negative-sense single-stranded RNA (vRNA) as its genome. Influenza virus RNA polymerase (RdRp) consists of three subunits PB2, PB1 and PA, and catalyzes both transcription and replication. Recently, intensive biochemical and structural analysis of its RdRp has been performed. In this paper, we review the details from the biochemical analysis of the purified influenza virus RdRp and the classical ribonucleoprotein complex, as well as piece together their structures to form an overall picture.
Shijian ZHANG , Tetsuya TOYODA . Molecular mechanisms of transcription and replication of the influenza A virus genome[J]. Frontiers in Biology, 2011 , 6(6) : 446 -461 . DOI: 10.1007/s11515-011-1151-5
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