New glimpses of caveolin-1 functions in embryonic development and human diseases
Received date: 14 Dec 2010
Accepted date: 30 Dec 2010
Published date: 01 Oct 2011
Copyright
Caveolin-1 (Cav-1) isoforms, including Cav-1α and Cav-1β, were identified as integral membrane proteins and the major components of caveolae. Cav-1 proteins are highly conserved during evolution from Caenorhabditis elegans to human and are capable of interacting with many signaling molecules through their caveolin scaffolding domains to regulate the activities of multiple signaling pathways. Thus, Cav-1 plays crucial roles in the regulation of cellular proliferation, differentiation and apoptosis in a cell-specific and contextual manner. In addition, Cav-1 is essential for embryonic development of vertebrates owing to its regulation of BMP, Wnt, TGF-β and other key signaling molecules. Moreover, Cav-1 is mainly expressed in terminally differentiated cells and its abnormal expression is often associated with human diseases, such as tumor progression, cardiovascular diseases, fibrosis, lung regeneration, and diseases related to virus. In this review, we will further discuss the potential of Cav-1 as a target for disease therapy and multiple drug resistance.
Key words： Caveolin-1; signal transduction; embryonic development; human diseases
Saijun MO , Shengli YANG , Zongbin CUI . New glimpses of caveolin-1 functions in embryonic development and human diseases[J]. Frontiers in Biology, 2011 , 6(5) : 367 -376 . DOI: 10.1007/s11515-011-1132-8
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