Smooth muscle cell differentiation: Mechanismsand models for vascular diseases
Received date: 27 Oct 2017
Accepted date: 21 Nov 2017
Published date: 10 Jan 2018
Copyright
BACKGROUND: Vascular smoothmuscle cells (VSMCs) are mature cells that play critical roles inboth normal and aberrant cardiovascular conditions. In response tovarious environmental cues, VSMCs can dedifferentiate from a contractilestate to a highly proliferative synthetic state through the so-called‘phenotypic switching’ process. Changes in VSMC phenotypecontribute to numerous vascular-related diseases, including atherosclerosis,calcification, and restenosis following angioplasty. Adventitial VSMCprogenitor cells also contribute to formation of the neointima.
METHODS/RESULTS: Herein, wereview both, the roles of VSMC differentiation in vascular diseases,and the in vitro models used to investigate the molecular mechanismsinvolved in the regulation of VSMC differentiation and phenotype modulation.
CONCLUSION: A comprehensiveunderstanding of VSMC behavior in vascular diseases is essential toidentify new therapeutic targets for the prevention and treatmentof cardiovascular diseases.
Yujie Deng , Caixia Lin , Huanjiao Jenny Zhou , Wang Min . Smooth muscle cell differentiation: Mechanismsand models for vascular diseases[J]. Frontiers in Biology, 2017 , 12(6) : 392 -405 . DOI: 10.1007/s11515-017-1473-z
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