Drosophila seizure disorders: genetic suppression of seizure susceptibility

Abstract

Various Drosophila models of human disease have recently received increased interest. The main goal is to uncover the fundamental biological basis for human pathology taking advantage of the power of Drosophila genetics. This review examines a set of Drosophila seizure-sensitive mutations that model human seizure disorders, especially epilepsy. Also described is a novel set of mutations that act as seizure-suppressors that ameliorate epilepsy phenotypes in double mutant combinations.

Key words： Drosophila; epilepsy; seizure disorders; sodium channel; seizure-suppressor genes

Acknowledgements

This study was supported by awards from the McKnight Foundation and the NIH (NS31231) to M.A.T. We thank the members of the Tanouye laboratory for helpful discussions throughout the project.

Arunesh Saras, Laura E. Simon, Harlan J. Brawer, Richard E. Price, Mark A. Tanouye declare that they have no conflict of interest.

This article does not contain any studies with human or vertebrate animal subjects performed by any of the authors.

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