Evaluation of microRNA-146a expression in acute lymphoblastic leukemia
Received date: 16 Dec 2015
Accepted date: 26 Jan 2016
Published date: 22 Mar 2016
Copyright
MicroRNAs (miRNAs) play an essential role in the development and progression of acute lymphoblastic leukemia (ALL), and could serve as disease biomarkers and therapeutic targets. The function of miR-146a in lymphoid differentiation has been here with discussed. However, the role of this miRNA in the outcome of ALL is not well understood. Peripheral blood of 48 patients with ALL and 20 age- and sex-matched healthy control subjects was used to accurately evaluate the expression of miR-146a by stem-loop Real time PCR. No statistically significant difference was found between patients and controls in total miR-146a expression. The expression of miR-146a was high (18.75%), low (27.08%) and not different (54.17%) in ALL patients. Our analysis indicated no association between the expression of miR-146a and any prognostic factors such as WBC/PLT counts, Hb, fusion genes (P190 and some translocations) with ALL type. This study revealed that miR-146a cannot be an independent factor for predicting the outcome of ALL patients. We suggest a multi-parameter analysis including miRNAs, transcription factors and critical genes to achieve a precise clinical panel for prognostic values.
Key words: miR-146a; acute lymphoblastic leukemia; prognostic marker
Farzaneh Tavakoli , Kaveh Jaseb , Mohammad Ali Jalali Far , Masoud Soleimani , Elahe Khodadi , Najmaldin Saki . Evaluation of microRNA-146a expression in acute lymphoblastic leukemia[J]. Frontiers in Biology, 2016 , 11(1) : 53 -58 . DOI: 10.1007/s11515-016-1387-1
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