Received date: 18 Apr 2015
Accepted date: 10 Jun 2015
Published date: 14 Aug 2015
Copyright
MicroRNAs (miRNAs) are 19-24 nucleotide non-coding ribonucleic acids binding DNA or RNA and controlling gene expression via mRNA degradation or its transcription inhibition. Erythropoies is a multi step differentiation process of erythroid progenitors to nucleate red blood cells. Maturation, proliferation and differentiation of red blood cells is affected by erythroid factors, signaling pathways in niche of hematopoietic cells, transcription factors as well as miRNAs. Expression of different types of miRNAs during erythroid development provides a background for the study of these molecules to control erythroid differentiation and maturation as well as their use as diagnostic and prognostic markers to treat erythroid disorders like thalassemia, sickle cell disease and erythrocyte enzyme deficiencies. In this paper, with reference to biosynthesis of miRNAs, their function in normal and anemic erythropoiesis has been investigated. The target molecule of each of these miRNAs has been cited in an attempt to elucidate their role in erythropoiesis.
Key words： miRNA; erythropoiesis; red blood cell
Javad Mohammdai-asl , Abolfazl Ramezani , Fatemeh Norozi , Amal Saki Malehi , Ali Amin Asnafi , Mohammad Ali Jalali Far , Seyed Hadi Mousavi , Najmaldin Saki . MicroRNAs in erythropoiesis and red blood cell disorders[J]. Frontiers in Biology, 2015 , 10(4) : 321 -332 . DOI: 10.1007/s11515-015-1365-z
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