MicroRNAs in erythropoiesis and red blood cell disorders

Abstract

MicroRNAs (miRNAs) are 19-24 nucleotide non-coding ribonucleic acids binding DNA or RNA and controlling gene expression via mRNA degradation or its transcription inhibition. Erythropoies is a multi step differentiation process of erythroid progenitors to nucleate red blood cells. Maturation, proliferation and differentiation of red blood cells is affected by erythroid factors, signaling pathways in niche of hematopoietic cells, transcription factors as well as miRNAs. Expression of different types of miRNAs during erythroid development provides a background for the study of these molecules to control erythroid differentiation and maturation as well as their use as diagnostic and prognostic markers to treat erythroid disorders like thalassemia, sickle cell disease and erythrocyte enzyme deficiencies. In this paper, with reference to biosynthesis of miRNAs, their function in normal and anemic erythropoiesis has been investigated. The target molecule of each of these miRNAs has been cited in an attempt to elucidate their role in erythropoiesis.

Keywords

miRNA / erythropoiesis / red blood cell

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Acknowledgements

This paper is issued from thesis of Abolfazl Ramezani, MSc student of hematology and blood banking. This work was financially supported by grant IR.AJUMS.REC. TH93/15 from vice chancellor for Research Affairs of Ahvaz Jundishapur University of Medical Sciences.

Javad Mohammdai-asl, Abolfazl Ramezani, Fatemeh Norozi, Amal Saki Malehi, Ali Amin Asnafi, Mohammad Ali Jalali Far, Seyed Hadi Mousavi, Najmaldin Saki declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by any of the authors.

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