REVIEW

Understanding of stem cells in bone biology and translation into clinical applications

  • Peng LIU , 1 ,
  • Zhipeng FAN 2 ,
  • Songlin WANG 2
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  • 1. Laboratory for Skeletal Development and Regenerative Medicine, The Key Laboratory of Oral Biomedicine (Wuhan), Ministry of Education, Wuhan University School of Stomatology, Wuhan 430070, China
  • 2. Molecular Laboratory for Gene Therapy & Tooth Regeneration, Capital Medical University School of Stomatology, Beijing 100050, China

Received date: 22 Sep 2010

Accepted date: 10 Oct 2010

Published date: 01 Oct 2010

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg

Abstract

Developments of stem cell biology provide new approaches for understanding the mechanisms of a number of diseases, including osteoporosis. In this mini-review, we highlight two areas that related to stem cells in bone biology. Recent discovery of the role of osteoclast and their stem cells leads to developing a new approach for treatment of osteoporosis with the initial stimulation of cells in osteoclast lineage and followed by sequentially enhanced bone formation. Stimulation on both sides in bone remodeling is expected to achieve a long term effect on bone formation. For bone regeneration, multiple disciplinary collaborations among bone biologists, stem cell biologists and biomaterial scientists are necessary to successfully develop an integrated stem cell therapy that should include stem cells, suitable scaffolds and bioactive factors/small molecular compounds.

Cite this article

Peng LIU , Zhipeng FAN , Songlin WANG . Understanding of stem cells in bone biology and translation into clinical applications[J]. Frontiers in Biology, 2010 , 5(5) : 396 -406 . DOI: 10.1007/s11515-010-0930-8

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