Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses
Received date: 15 May 2014
Accepted date: 18 Aug 2014
Published date: 13 Jan 2015
Copyright
Between 15% and 20% of human cancers are associated with infection by oncogenic viruses. Oncogenic viruses, including HPV, HBV, HCV and HTLV-1, target mitochondria to influence cell proliferation and survival. Oncogenic viral gene products also trigger the production of reactive oxygen species which can elicit oxidative DNA damage and potentiate oncogenic host signaling pathways. Viral oncogenes may also subvert mitochondria quality control mechanisms such as mitophagy and metabolic adaptation pathways to promote virus replication. Here, we will review recent progress on viral regulation of mitophagy and metabolic adaptation and their roles in viral oncogenesis.
Key words： mitochondria; mitophagy; virus; ROS; oncogenes
Young Bong CHOI , Edward William HARHAJ . Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses[J]. Frontiers in Biology, 2014 , 9(6) : 423 -436 . DOI: 10.1007/s11515-014-1332-0
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