Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses

Abstract

Between 15% and 20% of human cancers are associated with infection by oncogenic viruses. Oncogenic viruses, including HPV, HBV, HCV and HTLV-1, target mitochondria to influence cell proliferation and survival. Oncogenic viral gene products also trigger the production of reactive oxygen species which can elicit oxidative DNA damage and potentiate oncogenic host signaling pathways. Viral oncogenes may also subvert mitochondria quality control mechanisms such as mitophagy and metabolic adaptation pathways to promote virus replication. Here, we will review recent progress on viral regulation of mitophagy and metabolic adaptation and their roles in viral oncogenesis.

Keywords

mitochondria / mitophagy / virus / ROS / oncogenes

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Acknowledgements

The laboratories of E.W.H and Y.B.C. are funded by National Institutes of Health grants RO1CA135362 and R21AI103379 respectively.

Jamie K. Wong and Hongyan Zou declare that they have no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg