RNA-binding proteins in pluripotency, differentiation, and reprogramming
Received date: 15 May 2014
Accepted date: 20 Jul 2014
Published date: 11 Oct 2014
Copyright
Embryonic stem cell maintenance, differentiation, and somatic cell reprogramming require the interplay of multiple pluripotency factors, epigenetic remodelers, and extracellular signaling pathways. RNA-binding proteins (RBPs) are involved in a wide range of regulatory pathways, from RNA metabolism to epigenetic modifications. In recent years we have witnessed more and more studies on the discovery of new RBPs and the assessment of their functions in a variety of biological systems, including stem cells. We review the current studies on RBPs and focus on those that have functional implications in pluripotency, differentiation, and/or reprogramming in both the human and mouse systems.
Diana GUALLAR , Jianlong WANG . RNA-binding proteins in pluripotency, differentiation, and reprogramming[J]. Frontiers in Biology, 2014 , 9(5) : 389 -409 . DOI: 10.1007/s11515-014-1326-y
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