RNA-binding proteins in pluripotency, differentiation, and reprogramming

Abstract

Embryonic stem cell maintenance, differentiation, and somatic cell reprogramming require the interplay of multiple pluripotency factors, epigenetic remodelers, and extracellular signaling pathways. RNA-binding proteins (RBPs) are involved in a wide range of regulatory pathways, from RNA metabolism to epigenetic modifications. In recent years we have witnessed more and more studies on the discovery of new RBPs and the assessment of their functions in a variety of biological systems, including stem cells. We review the current studies on RBPs and focus on those that have functional implications in pluripotency, differentiation, and/or reprogramming in both the human and mouse systems.

Key words： RNA-binding protein; embryonic stem cell; pluripotency; differentiation; somatic cell reprogramming; lncRNA

Acknowledgements

We are grateful to Arven Saunders for critical reading and comments on the manuscript. The research in the Wang laboratory was funded by grants from the National Institutes of Health (NIH) and the Empire State Stem Cell Fund through New York State Department of Health (NYSTEM). J.W. is also a recipient of Irma T. Hirschl and Weill-Caulier Trusts Career Scientist Award.

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