A more robust Boolean model describing inhibitor binding

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  • 1.Center for Theoretical Biology, Peking University;Departments of Physics and Mathematics, the University of Hong Kong, ; 2.Center for Theoretical Biology, Peking University;Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94158, USA;

Published date: 05 Dec 2008

Abstract

From the first application of the Boolean model to the cell cycle regulation network of budding yeast, new regulative pathways have been discovered, particularly in the G1/S transition circuit. This discovery called for finer modeling to study the essential biology, and the resulting outcomes are first introduced in the article. A traditional Boolean network model set up for the new G1/S transition circuit shows that it cannot correctly simulate real biology unless the model parameters are fine tuned. The deficiency is caused by an overly coarse-grained description of the inhibitor binding process, which shall be overcome by a two-vector model proposed whose robustness is surveyed using random perturbations. Simulations show that the proposed two-vector model is much more robust in describing inhibitor binding processes within the Boolean framework.

Cite this article

XIE Zhaoqian Steven, TANG Chao . A more robust Boolean model describing inhibitor binding[J]. Frontiers of Electrical and Electronic Engineering, 2008 , 3(4) : 371 -375 . DOI: 10.1007/s11460-008-0079-2

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