A more robust Boolean model describing inhibitor binding

Abstract

From the first application of the Boolean model to the cell cycle regulation network of budding yeast, new regulative pathways have been discovered, particularly in the G1/S transition circuit. This discovery called for finer modeling to study the essential biology, and the resulting outcomes are first introduced in the article. A traditional Boolean network model set up for the new G1/S transition circuit shows that it cannot correctly simulate real biology unless the model parameters are fine tuned. The deficiency is caused by an overly coarse-grained description of the inhibitor binding process, which shall be overcome by a two-vector model proposed whose robustness is surveyed using random perturbations. Simulations show that the proposed two-vector model is much more robust in describing inhibitor binding processes within the Boolean framework.

Keywords

Boolean model / cell cycle / biological networks / inhibitor binding