Chiral ruthenium-SDPs/diamine complexes-catalyzed enantioselective hydrogenation of -alkyl arylacetones via dynamic kinetic resolution

Abstract

The asymmetric hydrogenation of the conformationally flexible racemic α-substituted acyclic dialkyl ketones via dynamic kinetic resolution (DKR) has been developed by using Ru-SDPs/diamine catalysts. Chiral alcohols were produced in high yields with good to excellent enantioselectivities (85%―97% ee) and diastereoselectivities (up to 97:3). This hydrogenation reaction provided a new approach to the synthesis of the key intermediate of J-104118.

Keywords

asymmetric hydrogenation / arylacetones / catalysis / diphosphine / diamine / ruthenium