Chiral ruthenium-SDPs/diamine complexes-catalyzed
enantioselective hydrogenation of -alkyl arylacetones via dynamic kinetic resolution

doi:10.1007/s11458-009-0093-9

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Front. Chem. China ›› 2009, Vol. 4 ›› Issue (3) : 299-306. DOI: 10.1007/s11458-009-0093-9

Research articles

Chiral ruthenium-SDPs/diamine complexes-catalyzed enantioselective hydrogenation of -alkyl arylacetones via dynamic kinetic resolution

Jianhua XIE , Weiling KONG , Xiaocheng WANG , Wenju BAI , Lixin WANG , Qilin ZHOU ,

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Abstract

The asymmetric hydrogenation of the conformationally flexible racemic α-substituted acyclic dialkyl ketones via dynamic kinetic resolution (DKR) has been developed by using Ru-SDPs/diamine catalysts. Chiral alcohols were produced in high yields with good to excellent enantioselectivities (85%―97% ee) and diastereoselectivities (up to 97:3). This hydrogenation reaction provided a new approach to the synthesis of the key intermediate of J-104118.

Keywords

asymmetric hydrogenation / arylacetones / catalysis / diphosphine / diamine / ruthenium

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Jianhua XIE , Weiling KONG , Xiaocheng WANG , Wenju BAI , Lixin WANG , Qilin ZHOU ,. Chiral ruthenium-SDPs/diamine complexes-catalyzed enantioselective hydrogenation of -alkyl arylacetones via dynamic kinetic resolution. Front. Chem. China, 2009, 4(3): 299‒306 https://doi.org/10.1007/s11458-009-0093-9