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Abstract
Biocompatible magnetic nanoparticles were prepared by co-precipitation method in the presence of poly(aspartic acid) (PAsp) as stabilizer, which was one of the most extensively studied and used poly(amino acids). As a biocompatible dispersant, PAsp was successfully attached to the Fe3O4 nanoparticles, which was approved by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA). From X-ray diffraction (XRD) and vibrating sample magnetometry (VSM) measurement results, it was found that PAsp stabilized iron oxide nanoparticles possess excellent Fe3O4 crystal structure and superparamagnetic property. Compared with trisodium citrate stabilized magnetic nanoparticles, PAsp stabilized magnetic nanoparticles were biocompatible and with lower cytotoxicity, which makes it more applicable in medicine, biology and biomaterial science.
Keywords
poly(aspartic acid) (PAsp)
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magnetic nanoparticles
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biocompatible, in vitro, cytotoxicity
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Peng YANG, Wei CHEN, Changchun WANG.
Preparation and in vitro cytotoxicity study of poly(aspartic acid) stabilized magnetic nanoparticles.
Front. Chem. China, 2011, 6(1): 9-14 DOI:10.1007/s11458-011-0222-0
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