Synthesis and biological studies of complexes of 2-amino- N (2-aminobenzoyl)benzohydrazide with Co(II), Ni(II), and Cu(II)

Abstract

The present work is concerned with the synthesis and coordination compounds of 2-amino-N(2-aminobezoyl)benzohydrazide (ABH). The ligand was synthesized by the reaction of methylanthranilate and hydrazine in 2:1 molar ratio. It can be viewed as a modified form of hydrazide. The ligand was characterized by ¹H-NMR, ¹³C-NMR, mass spectrometry, elemental analysis, and infrared studies. The ligand has got –NH₂ moeity, the site for chelation. The complexes of Co(II), Ni(II), and Cu(II) chlorides and bromides were prepared. These complexes were characterized by elemental analysis, infrared, conductance, and magnetic susceptibility studies. Infrared spectra studies confirmed the formation of complexes, while elemental studies suggested the complexation of [M(ABH)X₂] (where X= Cl^− or Br^−) composition.
Knowing about the importance of –N–N– linkage in the biologically active compounds, the synthesized complexes were studied for their biological activity, and were found to be potentially strong in inhibition activity as compared to the neat ligand.

Keywords

2-amino-N(2-aminobezoyl)benzohydrazide / coordination compounds / bioassay studies