Synthesis and fungicidal activity of novel 3,5-diarylpyrazole derivatives

Abstract

(E)-3-(2-chlorophenyl)-1-(2,4-dichlorophenyl)prop-2-en-1-one was prepared from 2-chlorobenzaldehyde followed by cyclization with hydrazine monohydrate. Eight new 3-(2,4-Di-chlorophenyl)-5-(2-chlorophenyl)-4,5- dihydro-N-acylpyrazole derivatives were synthesized and characterized by elemental analysis, IR and ¹H NMR spectroscopy. The experimental results show that the inhibition ratio of compounds 3f towards H. Oryzae and P. oryzae at 50 mg·L^-1 is 55.2% and 57.1%, respectively. The inhibition ratio of compounds 3g towards H. Oryzae, P. oryza, S. Sclerotiorum at 50 mg·L^-1 is 53.3%, 60.0%, 50.4% respectively.

Keywords

2-chlorobenzaldehyde / 3,5-diarylpyrazole / synthesis / fungicide