Preparation of porcine hemoglobin microcapsules of chitosan-sodium alginate

Abstract

Using an emulsification-gelation method, chitosan-sodium alginate-porcine hemoglobin microcapsules were prepared. Results show that these microcapsules have better forms and small granules with 1 ?m size of the mean particle size. They possess a relatively narrow and normal Gaussian distribution. The loading efficiency of porcine hemoglobin (pHb) in microcapsules is more than 90%. The pHb released from microcapsules is extended for more than one month. Chitosan-sodium alginate-hemoglobin micro capsules are expected to become an artificial oxygen-carrying therapeutic agent with sustained release for intravenous injection.

Keywords

chitosan-sodium alginate, microcapsules, hemo-globin, blood substitute